Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 64 (16 Oct 2019)
Sequence version 1 (03 May 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Tumor protein p53-binding protein, 2a

Gene

tp53bp2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • p53 binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tumor protein p53-binding protein, 2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tp53bp2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040516-8 tp53bp2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000009136 Expressed in 25 organ(s), highest expression level in paraxial mesoderm

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000010764

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 116DisorderedSequence analysisAdd BLAST33
Regioni316 – 337DisorderedSequence analysisAdd BLAST22
Regioni401 – 546DisorderedSequence analysisAdd BLAST146
Regioni566 – 585DisorderedSequence analysisAdd BLAST20
Regioni597 – 657DisorderedSequence analysisAdd BLAST61
Regioni682 – 701DisorderedSequence analysisAdd BLAST20
Regioni712 – 845DisorderedSequence analysisAdd BLAST134

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili122 – 156Sequence analysisAdd BLAST35
Coiled coili163 – 197Sequence analysisAdd BLAST35
Coiled coili201 – 235Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi401 – 423PolarSequence analysisAdd BLAST23
Compositional biasi620 – 634PolarSequence analysisAdd BLAST15
Compositional biasi755 – 810Pro-richSequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0515 Eukaryota
ENOG410Y17W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153463

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1R419

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPDGNPQ

Database of Orthologous Groups

More...
OrthoDBi
1041229at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105545

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1R419-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPMFLTVYL SNNDQHFSEV PITAETVCAD VLQLCREPGE NSSCYLSEVW
60 70 80 90 100
RGSERVVGEN EKMMDLLLQW GQQRPEVRFF LRHGRAASQP SDSRTQKRNG
110 120 130 140 150
VKKPADRRLE NGVNGPWMDM TLAELQEMAS RQQRQIDSQQ QLLSTKEQRL
160 170 180 190 200
RYLQQQEQRQ AQSSSEQKKL LQLRETLEQQ EAQLKMVRAL KGQVEQKRLS
210 220 230 240 250
NGKLVEQVEQ MNNLLHQKQK ELVVAVAKVE ELSKQLETLK SGQMDAMNSN
260 270 280 290 300
HSSVAELDRL YRELQMRKNL NVEQNAKLQQ QRENLNKRNQ EVANMDKRVS
310 320 330 340 350
ELRERLWKKK AALQQKENLP LPPDGQAPPQ TPGSRVAAVG PYIQSSTMPR
360 370 380 390 400
GPDRQDLPIK HNYPEFTATA GHQDRSAQPG AGLHSGKASS KLANWSLANA
410 420 430 440 450
KSGNNHVTSS LPRMVSQASK SQDNTDVQKR DPRVRPVSMF ESTDLPAAAL
460 470 480 490 500
RKNQSSEDLV RDAQSAVKTI VKVPPPVPSK PKQANFPSGG LMGLGKNTGT
510 520 530 540 550
YPGKSASPQP PAGPQTGTLP SKLEAPPAAT VHPFSPDPPG AKDTGGQMLL
560 570 580 590 600
KPQTVTASSI YSMYTQQPSS GKATQQSIQG ALSRAQTRTG HFISVYGKPV
610 620 630 640 650
TSAGQPSQTP HPENPYLDPP SVSETLTDHS PAEPISETPE TERIPRPLSP
660 670 680 690 700
TKLLPFISNP YRHQSDLDLE ALRKKLYNAP RPLKKRSSIT EPEGPGGPNI
710 720 730 740 750
QKLLYQKTTL AAMETVSPPG EEEKETLAKP QGYDAETPEV PEETLPEFPI
760 770 780 790 800
APEVEAEDVP PPPPPHPAPK IDASIIIPPP QPESPPPPPP PDSFMEDFPP
810 820 830 840 850
YPPPPYPSSA EQDNPDDTFN MKPPEVTGQV PFPPGKRTNL RKSGSERIDH
860 870 880 890 900
SMRVRFNPLA LLLDSSLEGE FDLVQRVIYE VEDPSQPNDE GITALHNAVC
910 920 930 940 950
AGHTEIVKFL VQYGVNVNAA DSDGWTPLHC AASCNNVQVC KFLVESGAAV
960 970 980 990 1000
FAMTYSDMQT AADKCEEMEE GYTQCSQFLY GVQEKMGIMN RGVVYGLWDY
1010 1020 1030 1040 1050
EAAQEDECSF REGDCMSVIR REDELETDWW WVRCGGAEGY VPRNLLGLYP
1060
RIKLRQRSLA
Length:1,060
Mass (Da):117,719
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC11D73F330F1C8C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4ISD9A0A0R4ISD9_DANRE
Tumor protein p53-binding protein, ...
tp53bp2a
1,056Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU462915 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005156532.1, XM_005156475.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000006892; ENSDARP00000010764; ENSDARG00000009136

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
407983

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU462915 Genomic DNA No translation available.
RefSeqiXP_005156532.1, XM_005156475.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010764

Genome annotation databases

EnsembliENSDART00000006892; ENSDARP00000010764; ENSDARG00000009136
GeneIDi407983

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
407983
ZFINiZDB-GENE-040516-8 tp53bp2a

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00940000153463
InParanoidiF1R419
OMAiKPDGNPQ
OrthoDBi1041229at2759
TreeFamiTF105545

Gene expression databases

BgeeiENSDARG00000009136 Expressed in 25 organ(s), highest expression level in paraxial mesoderm

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1R419_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1R419
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 16, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again