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Entry version 63 (26 Feb 2020)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

DNA topoisomerase II-binding protein 1

Gene

topbp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-5685938 HDR through Single Strand Annealing (SSA)
R-DRE-5693607 Processing of DNA double-strand break ends
R-DRE-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-69473 G2/M DNA damage checkpoint

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA topoisomerase II-binding protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:topbp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060626-1 topbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000059322 Expressed in anatomical structure and 28 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1R135 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000116677

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 181BRCTInterPro annotationAdd BLAST60
Domaini195 – 284BRCTInterPro annotationAdd BLAST90
Domaini358 – 448BRCTInterPro annotationAdd BLAST91
Domaini629 – 726BRCTInterPro annotationAdd BLAST98
Domaini906 – 997BRCTInterPro annotationAdd BLAST92
Domaini1273 – 1354BRCTInterPro annotationAdd BLAST82
Domaini1389 – 1486BRCTInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni286 – 314DisorderedSequence analysisAdd BLAST29
Regioni469 – 489DisorderedSequence analysisAdd BLAST21
Regioni721 – 819DisorderedSequence analysisAdd BLAST99
Regioni840 – 862DisorderedSequence analysisAdd BLAST23
Regioni1031 – 1066DisorderedSequence analysisAdd BLAST36
Regioni1093 – 1125DisorderedSequence analysisAdd BLAST33
Regioni1172 – 1201DisorderedSequence analysisAdd BLAST30
Regioni1496 – 1520DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi298 – 314PolarSequence analysisAdd BLAST17
Compositional biasi768 – 786PolarSequence analysisAdd BLAST19
Compositional biasi841 – 861PolarSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1929 Eukaryota
ENOG410XPFH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157001

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1R135

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYIYQGR

Database of Orthologous Groups

More...
OrthoDBi
557169at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326403

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113 SSF52113, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1R135-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKASKDAYI VKFVESNGQK SDVALQAYKA IVELQSEKYV QMVDEEAALE
60 70 80 90 100
LDHNDKSLFV FSDFTSSAFD HCRRLGCRIV SPLVVLFCLQ KQRCVPKAEQ
110 120 130 140 150
PVYNMSMADV TVSCTNLDKE ARSEVMDLIQ LMGGRVYRDL NVSVTHLVAG
160 170 180 190 200
EVGSKKYLVA ASLGKPILLP SWVKACWEKS QDSVFHHSEL NTEDYRCPVL
210 220 230 240 250
KGCTVCVTGL STVERKEVQR LCDQNGATYT GQLKMNECTH LIVNEPTGQK
260 270 280 290 300
YEFARKWNVY CVSLHWLFDS IEKGFCQDES RYAVERGDKR KTDDKSGRPN
310 320 330 340 350
TSTPTGQSRS KEDGPSLLGL SHISNISLNV NETALTTAGI SHIEMPDPVD
360 370 380 390 400
SFDITVCRVD DLLDGCKLYL CGLSGKKLEK LRRMVNTAGG LRFNQPTQEL
410 420 430 440 450
THIVMGEADQ GIKAFLDNAT HRPHIVTVQW LLESFSRGSL LPENGYFHPS
460 470 480 490 500
FLPPAPAAVD IPALHKAAPR ASRPSVAPPP APSPARQSRA EEDLLSQYMG
510 520 530 540 550
NDQTVVELPQ DTSSRHSVLH PEPLVEGKDS TLAEASEGGL FFGKRFILVG
560 570 580 590 600
FGAEAEAQLS ELVMENAGKI LVGRSRAVAH YAIVPLLGCD VEATVDEVAT
610 620 630 640 650
DTWLAMCVEQ QCVLPLASHP LFTPVAVREG FSPLKDCVLS VSQFTGAERD
660 670 680 690 700
SLIQLAKHLG ASVQDYFVRT ANQRKGMLAS THLVLQTPEG TKYQAAQKWG
710 720 730 740 750
LPAVTIRWVL ESARTGKRAD EGQYLVDLPP SPERTEDSFV GASQKDPPPL
760 770 780 790 800
RLHQRSPELP LLGPQNSDAI TPLDTARFQS RSVRSAVRKL KQGEEEQAEV
810 820 830 840 850
TTPGQEEAKG AQQKDSSLHL DTPSRFLSRD KLFGPSFNTK DVFDHLQTPG
860 870 880 890 900
NKSQQGQGAE TPLSEVIERN LKAAVANSNR SHVTNLAAMT ASPQLGKEPE
910 920 930 940 950
PEVEQKAAAP LSGVVVCVSK KLSKKQSELN AVAASLGAEF RWSCDDSVTH
960 970 980 990 1000
YIYQGKVGDN SKEYRAVKER GLYIVSQHWL QACADEQKHV SESLYPFTFN
1010 1020 1030 1040 1050
PKMSLTMSQM ADSTQRSPPS ATPRTRLRAF AENEETRLGP DDDITDVSTP
1060 1070 1080 1090 1100
KQGSVGEPEK DQTISTEKKN LTETLEMRES LQRQLQEIMS ATKLTSGRRG
1110 1120 1130 1140 1150
SSRLAKTGPG GLDSPHTPDS LGRMSRRSRN LEAIRMSRQV CVDLNTEPSQ
1160 1170 1180 1190 1200
SEQIVWDDPT AREERAKLAD NLQWPGSPSQ HSEPLALVPP PHSDHTTNGR
1210 1220 1230 1240 1250
DSMTDSELVE MAAFEVIDAQ LKPKGTSSRV DTLHNPKTPE APSIAFPISK
1260 1270 1280 1290 1300
TAALPLPRIE DEEEELKKDP PRFLLSSLNP QERIDYSHLI EELGGVVLEK
1310 1320 1330 1340 1350
QSFDPSCTHV IVGHPLRNEK YLAAMAAGKW ILHRSYLEAC RAEGHFIQED
1360 1370 1380 1390 1400
QYEWGSSSIL EALPSINSQQ KRLALAAMRW RKTLQGCSNK EGAFGGWIVM
1410 1420 1430 1440 1450
LNIDQAREAG FRRLLQSGGA KVLPDPSPSL FKETTHLFVD FSRLKPGDVR
1460 1470 1480 1490 1500
VDISEASAHG VKCLKPEYIA DYLMQEPSPS MDAYYLPGAA ADETEKVVDA
1510 1520
SSRKRKASGD MSTLKKSRMR
Length:1,520
Mass (Da):167,766
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACC5D64C9EA1FD71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8RVN3A0A2R8RVN3_DANRE
DNA topoisomerase II-binding protei...
topbp1
1,526Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX649325 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005162624.1, XM_005162567.2
XP_009295567.1, XM_009297292.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000082411; ENSDARP00000076846; ENSDARG00000059322
ENSDART00000140200; ENSDARP00000116677; ENSDARG00000059322

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
407679

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649325 Genomic DNA No translation available.
RefSeqiXP_005162624.1, XM_005162567.2
XP_009295567.1, XM_009297292.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116677

Genome annotation databases

EnsembliENSDART00000082411; ENSDARP00000076846; ENSDARG00000059322
ENSDART00000140200; ENSDARP00000116677; ENSDARG00000059322
GeneIDi407679

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11073
ZFINiZDB-GENE-060626-1 topbp1

Phylogenomic databases

eggNOGiKOG1929 Eukaryota
ENOG410XPFH LUCA
GeneTreeiENSGT00940000157001
InParanoidiF1R135
OMAiHYIYQGR
OrthoDBi557169at2759
TreeFamiTF326403

Enzyme and pathway databases

ReactomeiR-DRE-5685938 HDR through Single Strand Annealing (SSA)
R-DRE-5693607 Processing of DNA double-strand break ends
R-DRE-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-69473 G2/M DNA damage checkpoint

Gene expression databases

BgeeiENSDARG00000059322 Expressed in anatomical structure and 28 other tissues
ExpressionAtlasiF1R135 baseline

Family and domain databases

Gene3Di3.40.50.10190, 9 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
PfamiView protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits
SMARTiView protein in SMART
SM00292 BRCT, 8 hits
SUPFAMiSSF52113 SSF52113, 6 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1R135_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1R135
Secondary accession number(s): F1QTB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 26, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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