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Entry version 69 (29 Sep 2021)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Neutral sphingomyelinase (N-SMase) activation-associated factor

Gene

nsmaf

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-5626978, TNFR1-mediated ceramide production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neutral sphingomyelinase (N-SMase) activation-associated factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nsmafImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050417-342, nsmaf

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QZ06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000051920, Expressed in blastula and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1QZ06, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000068125

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 278BEACH-type PHInterPro annotationAdd BLAST98
Domaini282 – 567BEACHInterPro annotationAdd BLAST286
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati703 – 733WDPROSITE-ProRule annotationAdd BLAST31
Repeati752 – 793WDPROSITE-ProRule annotationAdd BLAST42
Repeati794 – 835WDPROSITE-ProRule annotationAdd BLAST42
Repeati876 – 911WDPROSITE-ProRule annotationAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1786, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000218_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QZ06

Identification of Orthologs from Complete Genome Data

More...
OMAi
MWMSELC

Database of Orthologous Groups

More...
OrthoDBi
101142at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F1QZ06

TreeFam database of animal gene trees

More...
TreeFami
TF324912

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06071, Beach, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1540.10, 1 hit
2.130.10.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR004182, GRAM
IPR023362, PH-BEACH_dom
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02138, Beach, 1 hit
PF02893, GRAM, 1 hit
PF00400, WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026, Beach, 1 hit
SM00568, GRAM, 1 hit
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS50082, WD_REPEATS_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1QZ06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFITKKDRS KERFSLLLLD LEEQYFEQHI AYNLTNRGPE TNRRTNGSLK
60 70 80 90 100
ICSKSVIFEP DDAVKPILKI PLKDCSEIAA VEETAHNPFI ESKPACIVIK
110 120 130 140 150
TKQIYQIKEE NVVAPYKYDR GEKKITFQLG SPIKTEDVVQ ILLQLHRASR
160 170 180 190 200
LDKQSDQTAM IAAILQSRLA RTRFDKNSFQ NVTELPHMEC EAEMVSPLVT
210 220 230 240 250
NAGHVCITDC NLYFQPLNSY PDSVVQIGLH SVRRIYKRRH GLRPLGLEVF
260 270 280 290 300
CTENDLCSDI YLKFYKTKDR DELYYYIATF LENHVAEHTA ESYMLQWQRG
310 320 330 340 350
HISNYQYLLH LNNLADRSVN DLSQYPVFPW VISDYSSTQL DLLNPASFRD
360 370 380 390 400
LSKPIGALNK ERLERLLERY RDMPEPRFMY GSHYSSPGYV LFYLVRVAPE
410 420 430 440 450
HMLCLQNGRF DHADRMFNSI GETWKNCLEG GTDFKELIPE FYGSDSSFLR
460 470 480 490 500
NLLGLDLGRR QGGGRVENVE LPPWASDPDD FLQKMCLALE SQYVSEHLHE
510 520 530 540 550
WIDLIFGYKQ RGSEAVASHN VFHPLTYEGG VDCDSIEDPD QKIAMLTQIL
560 570 580 590 600
EFGQTPRQLF VTPHPQRITP RFYNLSTTPS LSSSELSPVS PCMESFEDLT
610 620 630 640 650
EESRKMAWSN MNKLVLQSCH KIHKEAVTGV AVTLSGDSIF TTSQDSTLKM
660 670 680 690 700
FSKENGLQRS VSFSNMALSS CLMLPDDKIV VCSSWDNNVY FYSIAYGRRQ
710 720 730 740 750
DTLMGHDDAV SDICWRDDKL YTASWDSTVK VWECVAADIS SNKRTQFDPL
760 770 780 790 800
AEFEHEAGVN TLDLSPAGTL LATGTKEGTL TVWDLASPLP VNQLTCHSGK
810 820 830 840 850
IHQVAFSPDS RHILSVGEDS CLMVTDVQTG MLIATIPAEQ EQRCFCWDGN
860 870 880 890 900
TVLSGGISGD LSVWNLLNSK VVHKIPAAHS GAVTCMWMNE QCSSIITGGL
910
DKQIILWKPQ Y
Length:911
Mass (Da):103,358
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A518A5F2A9784AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8RZN8A0A2R8RZN8_DANRE
Neutral sphingomyelinase (N-SMase) ...
nsmaf
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR354563 Genomic DNA No translation available.
CU929087 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003199050.1, XM_003199002.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000073635; ENSDARP00000068125; ENSDARG00000051920

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
550506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:550506

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR354563 Genomic DNA No translation available.
CU929087 Genomic DNA No translation available.
RefSeqiXP_003199050.1, XM_003199002.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068125

Proteomic databases

PaxDbiF1QZ06

Genome annotation databases

EnsembliENSDART00000073635; ENSDARP00000068125; ENSDARG00000051920
GeneIDi550506
KEGGidre:550506

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8439
ZFINiZDB-GENE-050417-342, nsmaf

Phylogenomic databases

eggNOGiKOG1786, Eukaryota
GeneTreeiENSGT00940000155059
HOGENOMiCLU_000218_5_2_1
InParanoidiF1QZ06
OMAiMWMSELC
OrthoDBi101142at2759
PhylomeDBiF1QZ06
TreeFamiTF324912

Enzyme and pathway databases

ReactomeiR-DRE-5626978, TNFR1-mediated ceramide production

Gene expression databases

BgeeiENSDARG00000051920, Expressed in blastula and 25 other tissues
ExpressionAtlasiF1QZ06, baseline

Family and domain databases

CDDicd06071, Beach, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR004182, GRAM
IPR023362, PH-BEACH_dom
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138, Beach, 1 hit
PF02893, GRAM, 1 hit
PF00400, WD40, 3 hits
SMARTiView protein in SMART
SM01026, Beach, 1 hit
SM00568, GRAM, 1 hit
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS50082, WD_REPEATS_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QZ06_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QZ06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 29, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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