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UniProtKB - F1QXF5 (F1QXF5_DANRE)
Protein
Sodium channel protein
Gene
scn1lab
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: GO_Central
GO - Biological processi
- membrane depolarization during action potential Source: GO_Central
- neuronal action potential Source: ZFIN
- regulation of circadian rhythm Source: ZFIN
- regulation of glycolytic process Source: ZFIN
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of locomotor rhythm Source: ZFIN
- regulation of oxidative phosphorylation Source: ZFIN
- sodium ion transmembrane transport Source: GO_Central
- swimming behavior Source: ZFIN
- synaptic signaling Source: ZFIN
Keywordsi
Molecular function | Ion channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotationARBA annotation |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-DRE-5576892, Phase 0 - rapid depolarisation |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel proteinUniRule annotation |
Gene namesi | Name:scn1labImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060906-1, scn1lab |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- voltage-gated sodium channel complex Source: GO_Central
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 126 – 149 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 194 – 213 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 225 – 246 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 252 – 272 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 390 – 417 | HelicalUniRule annotationAdd BLAST | 28 | |
Transmembranei | 743 – 761 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 773 – 796 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 808 – 832 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 853 – 881 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 943 – 966 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 1200 – 1218 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1239 – 1258 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1270 – 1290 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1316 – 1342 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 1441 – 1464 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 1523 – 1541 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1553 – 1571 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1583 – 1603 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1640 – 1668 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 1744 – 1767 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000062744, Expressed in brain and 23 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 423 | Ion_transInterPro annotationAdd BLAST | 295 | |
Domaini | 543 – 692 | Na_trans_cytoplInterPro annotationAdd BLAST | 150 | |
Domaini | 743 – 970 | Ion_transInterPro annotationAdd BLAST | 228 | |
Domaini | 980 – 1193 | Na_trans_assocInterPro annotationAdd BLAST | 214 | |
Domaini | 1198 – 1473 | Ion_transInterPro annotationAdd BLAST | 276 | |
Domaini | 1522 – 1777 | Ion_transInterPro annotationAdd BLAST | 256 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 62 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 453 – 515 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 648 – 676 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1105 – 1150 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 1946 – 1996 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 55 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 466 – 480 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 493 – 515 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 659 – 676 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1947 – 1969 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1971 – 1996 | Basic and acidic residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000163423 |
OrthoDBi | 56920at2759 |
TreeFami | TF323985 |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR000048, IQ_motif_EF-hand-BS IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR024583, Na_trans_cytopl IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF06512, Na_trans_assoc, 1 hit PF11933, Na_trans_cytopl, 1 hit |
PRINTSi | PR00170, NACHANNEL |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
i Sequence
Sequence statusi: Complete.
F1QXF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQLLVPPG PDSFRPFLPE SLAAIEQRIA EEVAQRPKGE RRPDDDDENG
60 70 80 90 100
PKPNRDLEAG KPLPFIYGDV PPHMLSVPLE DLDTYYSNQK TFIVLNRGKA
110 120 130 140 150
IFRFNATPAL YILSPFNPLR RISIRVLVHS LFSFVIMCTI LTNCAFMTLS
160 170 180 190 200
NPPEWAKNVE YTFTGIYTFE SLIKILARGF CVGKFTFLRD PWNWLDFSVI
210 220 230 240 250
LMAYVTEFVN LGNVSALRTF RVLRALKTIS VIPGLKTIVG ALIQSVKKLS
260 270 280 290 300
DVMILTVFCL SVFALIGLQL FMGNLRQKCV KMPEVNVTDN LTDYSTELHN
310 320 330 340 350
STFNWTEYIS DSNNYYFIPG RRDALLCGNS SDAGQCPEGF TCIKAGRNPD
360 370 380 390 400
YGYTSFDTFS WAFLSLFRLM TQDFWENLYQ QTLRAAGKPY MIFFVLVIFL
410 420 430 440 450
GSFYLVNLIL AVVAMAYDEQ NQATIEEAQQ KEEEFQAMLE QLKRQQEEAQ
460 470 480 490 500
VAAAAATESG EYSGRGGLSE ESSSGGSRLS SKSAKERRNR RKKRKQREEE
510 520 530 540 550
EKADQEKFHK SASEDSIRRP GFRFSIDANR LSYEKKCSTP NQSLLSIRGS
560 570 580 590 600
LFSPRRNSRA SLFSFRGRAR DFGSENDFAD DEHSTFEDSD SRRGSLFVPR
610 620 630 640 650
CVERRSSTVS HCSLTAPRIM LPANGKMHCT VDCNGVVSLV GGTSVPTSPI
660 670 680 690 700
GRLLPEGTTT ESDVRKKRSG SHQPSDYLEE TVARKRAMSV ASILTNTMEE
710 720 730 740 750
LEESRQKCPP CWYKFANSFL IWDCSPAWLK VKEIMNMIVM DPFVDLAITI
760 770 780 790 800
CIVLNTLFMA MEHYPMTTQF SHLLSVGNLV FTGIFTAEMC LKVIALDPYY
810 820 830 840 850
YFQEGWNIFD GIIVSLSLME LGLANVEGLS VLRSFRLLRV FKLAKSWPTL
860 870 880 890 900
NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY RECVCKISES
910 920 930 940 950
CELPRWHMDD FFHSFLIVFR VLCGEWIETM WDCMEVAGQS MCLIVFMMVM
960 970 980 990 1000
VIGNLVVLNL FLALLLSSFS ADNLAATDDD SEMNNLQIAV GRIQKGIALV
1010 1020 1030 1040 1050
KSTLRQFLQS LFLAGSKPRS LDEEKPLDDL HSDGKENCLS NHAPVAVDLT
1060 1070 1080 1090 1100
KDYLKEGCVS PGNGVESHVK YGIEEGDYMS FIHNPSLTVT VPIAVGESDF
1110 1120 1130 1140 1150
ENLNTEDFSS ESSDVEGSKE KLPVDTVLSS SEGSTVDIRP PGEGAESVEL
1160 1170 1180 1190 1200
EPEESLDPEA CFTEGCVMRF QCCQVDVEKG KWKSWWILRK TCFIIVEHNW
1210 1220 1230 1240 1250
FESFIIFMIL LSSGALAFED IYIEQRKTIK TVLEYADKVF TYIFILEMLL
1260 1270 1280 1290 1300
KWVAYGFAKY FTNAWCWLDF LIVDVSLVSL VANALGYSEL SAIKSLRTLR
1310 1320 1330 1340 1350
ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF
1360 1370 1380 1390 1400
AGKYYYCVNI TNDELFPVSV VNNKSDCYAL IQNNDTARWK NVKINFDNVG
1410 1420 1430 1440 1450
AGYLALLQVA TFKGWMDIMY AAVDSRDLEQ QPVYETNLYM YLYFVIFIIF
1460 1470 1480 1490 1500
GSFFTLNLFI GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP
1510 1520 1530 1540 1550
QKPIPRPANK FQGLVFDLIT KQAFDIIIMI LICLNMVTMM VETDDQTEDM
1560 1570 1580 1590 1600
DNILYWINLV FIILFTGECV LKMISLRHYF FTIGWNVFDF VVVILSIVGM
1610 1620 1630 1640 1650
FLSEMIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA
1660 1670 1680 1690 1700
LFNIGLLLFL VMFIYAIFGM SNFAYVKREA GIDDMFNFET FGNSMLCLFQ
1710 1720 1730 1740 1750
ITTSAGWDGL LAPILNKQDP DCDSEMEHPG SFYRGNCGNP SVGIFFFVSY
1760 1770 1780 1790 1800
IIICFLIVVN MYIAVILENF SVATEESAEP LSEDDFEMFY EVWERFDPNA
1810 1820 1830 1840 1850
TQFVEYNKLS DFADALDPPL RIAKPNKIQL IAMDLPMVSG DRIHCLDILF
1860 1870 1880 1890 1900
AFTLRVLGEE GEMDALRGQM EDRFMASNPS KVSYEPITTT LRRKQEEMSA
1910 1920 1930 1940 1950
VVIQRAFRRH RIRQTVKKAS EAYRKQLQDG GGHIPEKEVL VIGKFQENSA
1960 1970 1980 1990
SDKTDMTPSS ASPPSYNSVA KSEKDKYEKE RREKEDKAKD ARDRKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX511272 Genomic DNA No translation available. CR396591 Genomic DNA No translation available. |
RefSeqi | NP_001038360.2, NM_001044895.2 XP_005165827.1, XM_005165770.3 XP_009300461.1, XM_009302186.2 XP_009300463.1, XM_009302188.2 |
Genome annotation databases
Ensembli | ENSDART00000090994; ENSDARP00000085427; ENSDARG00000062744 ENSDART00000151247; ENSDARP00000125843; ENSDARG00000062744 |
GeneIDi | 559447 |
KEGGi | dre:559447 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX511272 Genomic DNA No translation available. CR396591 Genomic DNA No translation available. |
RefSeqi | NP_001038360.2, NM_001044895.2 XP_005165827.1, XM_005165770.3 XP_009300461.1, XM_009302186.2 XP_009300463.1, XM_009302188.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000125843 |
Genome annotation databases
Ensembli | ENSDART00000090994; ENSDARP00000085427; ENSDARG00000062744 ENSDART00000151247; ENSDARP00000125843; ENSDARG00000062744 |
GeneIDi | 559447 |
KEGGi | dre:559447 |
Organism-specific databases
CTDi | 559447 |
ZFINi | ZDB-GENE-060906-1, scn1lab |
Phylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000163423 |
OrthoDBi | 56920at2759 |
TreeFami | TF323985 |
Enzyme and pathway databases
Reactomei | R-DRE-5576892, Phase 0 - rapid depolarisation |
Gene expression databases
Bgeei | ENSDARG00000062744, Expressed in brain and 23 other tissues |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR000048, IQ_motif_EF-hand-BS IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR024583, Na_trans_cytopl IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF06512, Na_trans_assoc, 1 hit PF11933, Na_trans_cytopl, 1 hit |
PRINTSi | PR00170, NACHANNEL |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1QXF5_DANRE | |
Accessioni | F1QXF5Primary (citable) accession number: F1QXF5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | January 19, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |