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UniProtKB - F1QV93 (F1QV93_DANRE)

Entry version 63 (07 Apr 2021)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Si:dkey-97a13.6

Gene

helz2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:dkey-97a13.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:helz2bImported
Synonyms:si:dkey-97a13.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070912-617, helz2b

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000012600, Expressed in granulocyte and 21 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini664 – 1254RNBInterPro annotationAdd BLAST591

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1097 – 1117Sequence analysisAdd BLAST21
Coiled coili1264 – 1298Sequence analysisAdd BLAST35

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000407_0_0_1

Family and domain databases

Conserved Domains Database

More...CDDi		cd18808, SF1_C_Upf1, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041679, DNA2/NAM7-like_C
IPR041677, DNA2/NAM7_AAA_11
IPR012340, NA-bd_OB-fold
IPR027417, P-loop_NTPase
IPR001900, RNase_II/R

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13086, AAA_11, 2 hits
PF13087, AAA_12, 2 hits
PF00773, RNB, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00955, RNB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 3 hits
SSF52540, SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

F1QV93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSADLYVREH FHPYIINGHP TLKLLRIKAN KGGSAIIATD DITRKYCLCS 
        60         70         80         90        100
RDGQSFILPA RSDLESHRII ITTTSIARHL HELKLPKGFF THILIDEASQ 
       110        120        130        140        150
MLEGEALMAL GLADKHTRVV LAGDHMQMAP KLFSVTDDKR SEHTLLNRLF 
       160        170        180        190        200
HYYQDQSINI AKKSRIIFNE NYRSTTEIVD FVSTYFYVSD GIKARGDVHP 
       210        220        230        240        250
HPRLKPLIFH HVRGECHLSS TITSTSWLNY AEVNSVVNMV QVLLTDWPME 
       260        270        280        290        300
WGDKDPKQIC VLSEGQQVAA IRIHLRRKGF YGVSVQNLAN IQGKQFRVII 
       310        320        330        340        350
ITTVHTRDKL LQLDSSCPEF FDDIRALNTA LTRAQSLVVV IGDAGALCCF 
       360        370        380        390        400
GKCSKVWRAY IEHCISKGSI KPDHFTRDVL QREVLEISKF QKTENVEKIE 
       410        420        430        440        450
TVVNLQAETD AILKEMENYD SDAQKSDDDN EQKRRIFTSA EKENLLEMVR 
       460        470        480        490        500
NQPALYKRGE LVMEGYQSGY IIPYDNPSER IDIKGRKNIG MSFPGDEVVV 
       510        520        530        540        550
EIRRHDEGHL TGRVLGLTNR SPTSSECVCS LEDENYNRKK LNPDQNLVPK 
       560        570        580        590        600
MMIPLDHTTT KIRILVKKEA RKLIPLWKCV SGNWTITGRV PINEQTKQNY 
       610        620        630        640        650
VFVVQILGWK EHCSFPLGRV TDILPVGTSL EEGLKILKSE FKLMSPPLMQ 
       660        670        680        690        700
ENTLLEIRID DKRRKDFTGL KTFTVDPPNA EVLDDAISIN DLGSCYEIGV 
       710        720        730        740        750
HVADVASFVS KDSSIDAFAK DMGATFYAPG KEPAFMFPKH LSTTCWSLLP 
       760        770        780        790        800
GKDRKAISLI VEVEKQSGVI TKKTFDLSMV KSKRQLTYNE AEDIICQCDG 
       810        820        830        840        850
ELRFDTLEDC VRVAYHFARS QRKTRLKEDW SYAQLNKHQK PGEREAHRMI 
       860        870        880        890        900
EELNIMFNHE VSKFLSEYTD TKSCTPLRCQ DSPNAEALEK ISNQHMELIP 
       910        920        930        940        950
FSSHLTFHLE RQRMDLNNAV TFTVYSLGSR YVHPNNNPNP EANSSPLSSQ 
       960        970        980        990       1000
LRDAISVSES EFHFEIGIHK ADFLNYVSED NIQNLGAQSD MWNLAPGKKR 
      1010       1020       1030       1040       1050
CAISLMLKVE KRNGKLVEEK MVLSRIRSCK ALSYSEADSI INQLGEKEMK 
      1060       1070       1080       1090       1100
FGTLEDCILV VCRFALDHRT KRLSRQVNSS NPSDLASSED SKCRLMMEEL 
      1110       1120       1130       1140       1150
KLMFKRASDQ IINQQTQFPN TSPGLVNRLK KYNEKFESLQ VLEKCLDPNN 
      1160       1170       1180       1190       1200
GQNCGSFIIL TSVWKKIKSA ALTCDFYKMA DLISTDDIHP QLVPAIVQLS 
      1210       1220       1230       1240       1250
ASINKAFFIR SLSCREALVG HYSLHLDSYT HASSPIRRYI DVVLQRLMHA 
      1260       1270       1280       1290       1300
VLGNRPVEYS QTDIDLLCEK CKRGEKRAQE YESKVEALQI AVNLQKQSTY 
      1310       1320       1330       1340       1350
KVAFVTVVKR DSESFKLSFP FDKGTFPEKL PVQYRNLQLE DQPLFIKKPK 
      1360       1370       1380       1390       1400
HVKLTWKKRI YGLSMTQSPL QNMKISSEIQ QSTWQAIVEA VRDEKWDEAK 
      1410       1420       1430       1440       1450
SLVLAAHVKD NSRNSELSDT SRWDPDRTFT SEEDHYTDFQ INLKVGDTVQ 
      1460       1470       1480       1490       1500
VQLTSERDRG YWAPTVQLFR LSSSFEICVE HTDNPIKCFS RIADHPSKGS 
      1510       1520       1530       1540       1550
YSNVEEYVQI WRPLCEMESA ATAVDDSDCV VIENVAITWD DSRLSGNFSL 
      1560       1570       1580       1590       1600
PEENIKKWAI EFDLGRCLLC IRKRDLEQNQ AEQSELDPKY FTWVAHAVTT 
      1610       1620       1630       1640       1650
LCSDSPENSG NKFKIINFNV KYASMKIPKF KRNETFTVEI IPKLLPDIRK 
      1660       1670       1680       1690       1700
ESAVNNLKGA NELVQNIALK HRIVNQSSNQ DVPLYLLMRE EAPAGLPQLN 
      1710       1720       1730       1740       1750
ESQFKALEKA LNGKFTIIQG PPGTGKTVVG AYIVYWFSQL NSRNLWRLKD 
      1760       1770       1780       1790       1800
PTDKDKREVI LYCGPSNKSV DVVAEYLLKF GEKLKLLRVY SRQMEMQEYP 
      1810       1820       1830       1840       1850
YPGSNLQLSH KSRQERSKPE LRAITLHHRI RMGHNPYSQR ITDFDDRIKS 
      1860       1870       1880       1890       1900
DPYSLTDTDI EEYKKLLNDA RLHELERHDI ILCTCTAAAS PNLKKTLSAR 
      1910       1920       1930       1940       1950
QILIDECAMA TEPQTLVPLV SFKPEKVVLL GDHKQLRPIV KNNHVRRLGM 
      1960       1970       1980       1990       2000
TRSLFERYMD RAIMLDTQYR MHEEICKFPS EAYYNDMLKT VVRERTSVLN 
      2010       2020       2030       2040       2050
AETEGRRQSK RILFGDIRGE EIGLVVSTAR GNENSKANFD EVKKAVEICI 
      2060       2070       2080       2090       2100
QLVTVGRVRP EDIAILSPYN AQVAQIRERL SDFELKGFTV TTITKSQGSE 
      2110       2120       2130       2140       2150
WQYVILSIVR SCPSDEIEPM PSREWLSKHI GFVGDENQIN VGITRAQVGL 
      2160       2170       2180       2190
CILGNQAVLN CSPAWQKLLK HYSGHGCVVT ADQITVHRVR
Length:2,190
Mass (Da):250,140
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C2D7420DED0407
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX663525 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000131278; ENSDARP00000122617; ENSDARG00000012600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX663525 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Genome annotation databases

EnsembliENSDART00000131278; ENSDARP00000122617; ENSDARG00000012600

Organism-specific databases

ZFINiZDB-GENE-070912-617, helz2b

Phylogenomic databases

GeneTreeiENSGT00940000160694
HOGENOMiCLU_000407_0_0_1

Gene expression databases

BgeeiENSDARG00000012600, Expressed in granulocyte and 21 other tissues

Family and domain databases

CDDicd18808, SF1_C_Upf1, 2 hits
InterProiView protein in InterPro
IPR041679, DNA2/NAM7-like_C
IPR041677, DNA2/NAM7_AAA_11
IPR012340, NA-bd_OB-fold
IPR027417, P-loop_NTPase
IPR001900, RNase_II/R
PfamiView protein in Pfam
PF13086, AAA_11, 2 hits
PF13087, AAA_12, 2 hits
PF00773, RNB, 2 hits
SMARTiView protein in SMART
SM00955, RNB, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF52540, SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QV93_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QV93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 7, 2021
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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