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Entry version 54 (16 Oct 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Si:dkey-97a13.6

Gene

si:dkey-97a13.6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:dkey-97a13.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:dkey-97a13.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070912-617 si:dkey-97a13.6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000012600 Expressed in 14 organ(s), highest expression level in liver

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini664 – 1254RNBInterPro annotationAdd BLAST591

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1097 – 1117Sequence analysisAdd BLAST21
Coiled coili1264 – 1298Sequence analysisAdd BLAST35

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1804 Eukaryota
KOG2102 Eukaryota
COG0557 LUCA
COG1112 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160694

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR001900 RNase_II/R

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086 AAA_11, 2 hits
PF13087 AAA_12, 2 hits
PF00773 RNB, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00955 RNB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 3 hits
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

F1QV93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSADLYVREH FHPYIINGHP TLKLLRIKAN KGGSAIIATD DITRKYCLCS
60 70 80 90 100
RDGQSFILPA RSDLESHRII ITTTSIARHL HELKLPKGFF THILIDEASQ
110 120 130 140 150
MLEGEALMAL GLADKHTRVV LAGDHMQMAP KLFSVTDDKR SEHTLLNRLF
160 170 180 190 200
HYYQDQSINI AKKSRIIFNE NYRSTTEIVD FVSTYFYVSD GIKARGDVHP
210 220 230 240 250
HPRLKPLIFH HVRGECHLSS TITSTSWLNY AEVNSVVNMV QVLLTDWPME
260 270 280 290 300
WGDKDPKQIC VLSEGQQVAA IRIHLRRKGF YGVSVQNLAN IQGKQFRVII
310 320 330 340 350
ITTVHTRDKL LQLDSSCPEF FDDIRALNTA LTRAQSLVVV IGDAGALCCF
360 370 380 390 400
GKCSKVWRAY IEHCISKGSI KPDHFTRDVL QREVLEISKF QKTENVEKIE
410 420 430 440 450
TVVNLQAETD AILKEMENYD SDAQKSDDDN EQKRRIFTSA EKENLLEMVR
460 470 480 490 500
NQPALYKRGE LVMEGYQSGY IIPYDNPSER IDIKGRKNIG MSFPGDEVVV
510 520 530 540 550
EIRRHDEGHL TGRVLGLTNR SPTSSECVCS LEDENYNRKK LNPDQNLVPK
560 570 580 590 600
MMIPLDHTTT KIRILVKKEA RKLIPLWKCV SGNWTITGRV PINEQTKQNY
610 620 630 640 650
VFVVQILGWK EHCSFPLGRV TDILPVGTSL EEGLKILKSE FKLMSPPLMQ
660 670 680 690 700
ENTLLEIRID DKRRKDFTGL KTFTVDPPNA EVLDDAISIN DLGSCYEIGV
710 720 730 740 750
HVADVASFVS KDSSIDAFAK DMGATFYAPG KEPAFMFPKH LSTTCWSLLP
760 770 780 790 800
GKDRKAISLI VEVEKQSGVI TKKTFDLSMV KSKRQLTYNE AEDIICQCDG
810 820 830 840 850
ELRFDTLEDC VRVAYHFARS QRKTRLKEDW SYAQLNKHQK PGEREAHRMI
860 870 880 890 900
EELNIMFNHE VSKFLSEYTD TKSCTPLRCQ DSPNAEALEK ISNQHMELIP
910 920 930 940 950
FSSHLTFHLE RQRMDLNNAV TFTVYSLGSR YVHPNNNPNP EANSSPLSSQ
960 970 980 990 1000
LRDAISVSES EFHFEIGIHK ADFLNYVSED NIQNLGAQSD MWNLAPGKKR
1010 1020 1030 1040 1050
CAISLMLKVE KRNGKLVEEK MVLSRIRSCK ALSYSEADSI INQLGEKEMK
1060 1070 1080 1090 1100
FGTLEDCILV VCRFALDHRT KRLSRQVNSS NPSDLASSED SKCRLMMEEL
1110 1120 1130 1140 1150
KLMFKRASDQ IINQQTQFPN TSPGLVNRLK KYNEKFESLQ VLEKCLDPNN
1160 1170 1180 1190 1200
GQNCGSFIIL TSVWKKIKSA ALTCDFYKMA DLISTDDIHP QLVPAIVQLS
1210 1220 1230 1240 1250
ASINKAFFIR SLSCREALVG HYSLHLDSYT HASSPIRRYI DVVLQRLMHA
1260 1270 1280 1290 1300
VLGNRPVEYS QTDIDLLCEK CKRGEKRAQE YESKVEALQI AVNLQKQSTY
1310 1320 1330 1340 1350
KVAFVTVVKR DSESFKLSFP FDKGTFPEKL PVQYRNLQLE DQPLFIKKPK
1360 1370 1380 1390 1400
HVKLTWKKRI YGLSMTQSPL QNMKISSEIQ QSTWQAIVEA VRDEKWDEAK
1410 1420 1430 1440 1450
SLVLAAHVKD NSRNSELSDT SRWDPDRTFT SEEDHYTDFQ INLKVGDTVQ
1460 1470 1480 1490 1500
VQLTSERDRG YWAPTVQLFR LSSSFEICVE HTDNPIKCFS RIADHPSKGS
1510 1520 1530 1540 1550
YSNVEEYVQI WRPLCEMESA ATAVDDSDCV VIENVAITWD DSRLSGNFSL
1560 1570 1580 1590 1600
PEENIKKWAI EFDLGRCLLC IRKRDLEQNQ AEQSELDPKY FTWVAHAVTT
1610 1620 1630 1640 1650
LCSDSPENSG NKFKIINFNV KYASMKIPKF KRNETFTVEI IPKLLPDIRK
1660 1670 1680 1690 1700
ESAVNNLKGA NELVQNIALK HRIVNQSSNQ DVPLYLLMRE EAPAGLPQLN
1710 1720 1730 1740 1750
ESQFKALEKA LNGKFTIIQG PPGTGKTVVG AYIVYWFSQL NSRNLWRLKD
1760 1770 1780 1790 1800
PTDKDKREVI LYCGPSNKSV DVVAEYLLKF GEKLKLLRVY SRQMEMQEYP
1810 1820 1830 1840 1850
YPGSNLQLSH KSRQERSKPE LRAITLHHRI RMGHNPYSQR ITDFDDRIKS
1860 1870 1880 1890 1900
DPYSLTDTDI EEYKKLLNDA RLHELERHDI ILCTCTAAAS PNLKKTLSAR
1910 1920 1930 1940 1950
QILIDECAMA TEPQTLVPLV SFKPEKVVLL GDHKQLRPIV KNNHVRRLGM
1960 1970 1980 1990 2000
TRSLFERYMD RAIMLDTQYR MHEEICKFPS EAYYNDMLKT VVRERTSVLN
2010 2020 2030 2040 2050
AETEGRRQSK RILFGDIRGE EIGLVVSTAR GNENSKANFD EVKKAVEICI
2060 2070 2080 2090 2100
QLVTVGRVRP EDIAILSPYN AQVAQIRERL SDFELKGFTV TTITKSQGSE
2110 2120 2130 2140 2150
WQYVILSIVR SCPSDEIEPM PSREWLSKHI GFVGDENQIN VGITRAQVGL
2160 2170 2180 2190
CILGNQAVLN CSPAWQKLLK HYSGHGCVVT ADQITVHRVR
Length:2,190
Mass (Da):250,140
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C2D7420DED0407
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX663525 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000131278; ENSDARP00000122617; ENSDARG00000012600

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX663525 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

EnsembliENSDART00000131278; ENSDARP00000122617; ENSDARG00000012600

Organism-specific databases

ZFINiZDB-GENE-070912-617 si:dkey-97a13.6

Phylogenomic databases

eggNOGiKOG1804 Eukaryota
KOG2102 Eukaryota
COG0557 LUCA
COG1112 LUCA
GeneTreeiENSGT00940000160694

Gene expression databases

BgeeiENSDARG00000012600 Expressed in 14 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR001900 RNase_II/R
PfamiView protein in Pfam
PF13086 AAA_11, 2 hits
PF13087 AAA_12, 2 hits
PF00773 RNB, 2 hits
SMARTiView protein in SMART
SM00955 RNB, 1 hit
SUPFAMiSSF50249 SSF50249, 3 hits
SSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QV93_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QV93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 16, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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