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Entry version 76 (17 Jun 2020)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

Regulator of G protein-signaling 12a

Gene

rgs12a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Regulator of G protein-signaling 12aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rgs12aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-2614 rgs12a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QV08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000009610 Expressed in eye and 23 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000040533

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 91PDZInterPro annotationAdd BLAST78
Domaini681 – 798RGSInterPro annotationAdd BLAST118
Domaini934 – 1004RBDInterPro annotationAdd BLAST71
Domaini1006 – 1076RBDInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni151 – 171DisorderedSequence analysisAdd BLAST21
Regioni400 – 430DisorderedSequence analysisAdd BLAST31
Regioni475 – 524DisorderedSequence analysisAdd BLAST50
Regioni632 – 660DisorderedSequence analysisAdd BLAST29
Regioni813 – 854DisorderedSequence analysisAdd BLAST42
Regioni872 – 916DisorderedSequence analysisAdd BLAST45
Regioni1078 – 1133DisorderedSequence analysisAdd BLAST56
Regioni1169 – 1314DisorderedSequence analysisAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi405 – 430PolarSequence analysisAdd BLAST26
Compositional biasi497 – 511PolarSequence analysisAdd BLAST15
Compositional biasi646 – 660PolarSequence analysisAdd BLAST15
Compositional biasi832 – 854PolyampholyteSequence analysisAdd BLAST23
Compositional biasi890 – 916PolarSequence analysisAdd BLAST27
Compositional biasi1186 – 1201PolarSequence analysisAdd BLAST16
Compositional biasi1257 – 1271Pro-richSequence analysisAdd BLAST15
Compositional biasi1290 – 1309PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QV08

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSTHMAS

Database of Orthologous Groups

More...
OrthoDBi
275783at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1QV08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLDRPISP AVRRVEMERG RAGYGFTIAG QAPCVLRGII KGSPAHSVGL
60 70 80 90 100
LPGDRVLRVN DTDVSEASHD VVVKLIGTSS KSLCLLVTSG DRPPMACCSS
110 120 130 140 150
DEELGCQNKS KRPWLNPGIK DPFPGKLDGR DLKEPILQSV GSFDTVFEIS
160 170 180 190 200
DQGTMTPHQE KQKKQRPLSE PDVSYWLQQQ QRSKGNVDIL SQDETSRVVS
210 220 230 240 250
EDSVFSDLQS QNDLASDSSI LNVAMIVGYI NSMELELVMS QTEEDALQVI
260 270 280 290 300
RQCISKIGIE QKTHSLVLMK VKCNCVQLCD DRDVVLASYP AENLALCVIC
310 320 330 340 350
TEDSRFFGLV SIDSTKNIDT GRQTSTLKTL CHVFFIDPEL YEHKEHQSII
360 370 380 390 400
GHFGIPCTPD PDTQSCLEFP QTPHSISHFI SVLYADMGDY IEKLRLKLDS
410 420 430 440 450
ENPDEGSQNA RNSGSGSGSD SGIGNASPEE RDSLIGQWSF TSPNICNPPP
460 470 480 490 500
PYYSQHRNST FLKPECRCLL SEPLTGSAQP ATPSGVPAGA DGSAFTPVPL
510 520 530 540 550
SKQSNLPPKQ RAGQRRPSIG LKARWQKSRP NSIECLVEGD NDDPKSKCST
560 570 580 590 600
LPPAMEQIPT LRYKPLEHTQ RINFTPQLEL TSRFFSSAAK QKDGENKGSL
610 620 630 640 650
FWALTRGRSS VRRPSGPAKR LSLAHSLNDL ESAASDGERS GGGVQRHDCS
660 670 680 690 700
SVSSLDSNGS LPSVTNHCRF TERRVALWAV SFERLLQDPV GVRYFSEFLK
710 720 730 740 750
KEFSEENILF WQACECFSQV PEHDKKQLSQ KAKEIYNRFL SSKATMPVNI
760 770 780 790 800
DSQAQLADDV LTAPQPNMFK QPQLQIFNLM KMDSYARFLK STLYQECMLA
810 820 830 840 850
EVEGRPLPDP CPIPCSPAPS KHSFTSDRST FSTPKKENRK PKTGRSSDDL
860 870 880 890 900
REKHSDKKNG FFSWYRYPSI GKGQKKREAP DLPYHCNGRR ESQGSLSSGA
910 920 930 940 950
SQELNTSCSG GKNEQCELRG SSCALDKERE RCSRTCTVTL PDGSSCSIPL
960 970 980 990 1000
RQGASIRQVL LELCQKQHIN LAAVDLFLTG GEKPLVLDQD SITLSSRELR
1010 1020 1030 1040 1050
LEKRTLFRLD LVPINRSVGL KAKPTKPVTE VLRPVVAKYG LQLGDLVARI
1060 1070 1080 1090 1100
SGETEVLDLG VPISNLDGLR VVLERADPAK EKSKTLNSKT PAAKKGFPRE
1110 1120 1130 1140 1150
RDDNSTVKPL KADVEDKHPR TAASERKKGK KNHIDETEEF FELLSRAQSS
1160 1170 1180 1190 1200
RVDDQRGLLR KEDLVLPDFL RVNPDPKPQS PPSCSTPTSH KPGHTTTTST
1210 1220 1230 1240 1250
NPHPPKPSPC NGHQASAPFS APLSPILRSA GAREQEEEEG LGDLTLVAEG
1260 1270 1280 1290 1300
DISSPNSTLL PPPPPVSPPP YDGSLAEANF TPPPAVHGTG TEEENTSTSA
1310 1320 1330 1340 1350
VNSSTAQPDL RVRDKGVTLE DSFEGYAAEL RQCQNKMRNG VYPSTEAPRP
1360 1370
LSGVLEVNES DTVQYKATFV
Length:1,370
Mass (Da):150,721
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A026D40C1B475D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5NSF6A0A1D5NSF6_DANRE
Regulator of G protein-signaling 12...
rgs12a
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX324131 Genomic DNA No translation available.
BX324198 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009301360.1, XM_009303085.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000040534; ENSDARP00000040533; ENSDARG00000009610
ENSDART00000173969; ENSDARP00000142671; ENSDARG00000009610

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
570516

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX324131 Genomic DNA No translation available.
BX324198 Genomic DNA No translation available.
RefSeqiXP_009301360.1, XM_009303085.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000040533

Proteomic databases

PaxDbiF1QV08

Genome annotation databases

EnsembliENSDART00000040534; ENSDARP00000040533; ENSDARG00000009610
ENSDART00000173969; ENSDARP00000142671; ENSDARG00000009610
GeneIDi570516

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
570516
ZFINiZDB-GENE-030131-2614 rgs12a

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000164407
HOGENOMiCLU_002190_0_0_1
InParanoidiF1QV08
OMAiYSTHMAS
OrthoDBi275783at2759
TreeFamiTF328814

Gene expression databases

BgeeiENSDARG00000009610 Expressed in eye and 23 other tissues

Family and domain databases

Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QV08_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QV08
Secondary accession number(s): A0A1D5NS62
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 20, 2018
Last modified: June 17, 2020
This is version 76 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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