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Entry version 43 (13 Nov 2019)
Sequence version 2 (16 Oct 2019)
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Protein

Alpha-protein kinase 2

Gene

alpk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-protein kinase 21 Publication (EC:2.7.11.1By similarity)
Alternative name(s):
Heart alpha-protein kinaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:alpk2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-1868 alpk2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morpholino knockdown in the embryo causes reduced heart beating rates and cardiomyocyte numbers at 48 hours post-fertilization (hpf) (PubMed:29888752). At 72 hpf, embryos display pericardial and yolk sac effusion and pronounced cardiac malformation coupled with defects in posterior development (PubMed:29888752). Embryos also lack ventricular epicardium at 96 hpf (PubMed:29888752).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004480621 – 1966Alpha-protein kinase 2Add BLAST1966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1599 ↔ 1649PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QU13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in developing cardiac tissue.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at 13 hours post-fertilization (hpf) in the precursor cells of adaxial cells (slow twitch muscle fibers) of the paraxial mesoderm (PubMed:29888752). At 22 hpf, detected in the developing heart (PubMed:29888752).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000079637 Expressed in 12 organ(s), highest expression level in muscle tissue

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1577 – 1659Ig-likePROSITE-ProRule annotationAdd BLAST83
Domaini1702 – 1934Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST233

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHFU Eukaryota
ENOG410Y8B3 LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSTSEYH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02816 Alpha_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811 Alpha_kinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1QU13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAKRVDMAA PDNLLFLDSD AVNSSPASVP IEQNEPTHVL DNQTDDSLRS
60 70 80 90 100
MPDPHTNTAL ESTGLMPVPC QDETLETHSQ HNEGENESSL VSTQHMDHTR
110 120 130 140 150
LTEMTINDEK SNNWDFDISG VKENDNSTNL NPDLIHHAGT DSVMERNLND
160 170 180 190 200
KQTDLNHKDE TFGSLMSSEV LLLKENRQQE MSQDTNLHQC SSSESTGIEY
210 220 230 240 250
SQTANDAISD AMNSEQSPDQ PFSIASNDTD KTTSECSVQT CWDTVESAAT
260 270 280 290 300
SKTQPELHDD VKDVMCESFT TSQTLNIDYL STDISVCLAD LPETDSLNIL
310 320 330 340 350
TPASTLLGIL GKNNNVLKTA DVPINDSEMV QSINKDLASP NADISKTVFT
360 370 380 390 400
QMDQNLLHVT DHNVKVLESN RADTVVDQYV FSENIGQEVS QASSHDEDLN
410 420 430 440 450
SSVQSHDQQL STANSEIEET SSEFHTQTCQ DIHEGVIIAE EAMNGHNTLP
460 470 480 490 500
EMHDIADVTT SQTPIMKDPM IDEPSYLPDL HKADTPNVIT TASTLSDTLE
510 520 530 540 550
TDDSIFETAD VSVSDCELIQ TVTLKTVTTY ETLLMMHDVG EDLTCCDFTT
560 570 580 590 600
SAIEEPETSH PLSLDDLHES NTPNIPPHAS ALLDSLGMNK NFLETADVPV
610 620 630 640 650
SDCEVIQTVT FETVTTYETF PVMHDIAEDL TCCDFTTSET PKIEEPETSH
660 670 680 690 700
SLSLDDLNEA NTPNILPHAS ALLESLGMNN NFLEAADMPV SDREIIHPVN
710 720 730 740 750
KDLDSSSVEI CTVVLTQTDP KEVQDSDLDE KETESNRIDD SIDGMIDTKF
760 770 780 790 800
SLDVSKLQPV CSNDLSGTVI HSESLFSQSI PDTPQIGEKY KNDLLQVISP
810 820 830 840 850
PTPVTNEDLG NCSEEIDDAC LKFTGTERDV EGDSELWLEP SQFLAGEEDE
860 870 880 890 900
GAIFDKWGRS CSSSPPTTHP DNTKASDYTW RENISIDHNA EDWELTFPPV
910 920 930 940 950
ERWSSSDSWA SALSDWFQAV NTYPEDSFKS ASTGSKLGMA IQDNILEQRT
960 970 980 990 1000
SSDNANNDEQ TCLSLNLMQP DEPGQALERG LVKSDNTNGT VFKQGDKERL
1010 1020 1030 1040 1050
ASCLDMDKDT TTMESQMSLL ETSTPESHKA DNNAVMETFN ASLTHEFNAK
1060 1070 1080 1090 1100
LHGSLDISGK LLSAKREGNV LVEVTGGKVS QLGLVFEEER QSIFTSPSSS
1110 1120 1130 1140 1150
AYTRDKNLTG CVSNEERCHS SDVHLCICPS QSDSHVSSKA GHAEGNGSFL
1160 1170 1180 1190 1200
HSNIGNCTVK PYVEENIPQF IMPFAPICTG NTFLHRSFLK EDRSQADLDL
1210 1220 1230 1240 1250
PDKKIINKIN LKSNKKSSSS DDSSEDNFHT CPDQSLSSSS GDSDDPSITD
1260 1270 1280 1290 1300
SGRKPAYSDT CDIGKELSKL LLLTGEHFMV SEDKRIAYVT LDLDESQHFG
1310 1320 1330 1340 1350
RFSLPNCEKQ SKPDNMPHKT SKTSSDGKMR SKHKEKPDDK QQHGIQASKK
1360 1370 1380 1390 1400
QDPQPQSQVK NEGAGCEDCP VAVIETIVIT EKIIPKTQGK KKKKHVQHGT
1410 1420 1430 1440 1450
PKPENDAPTD VRSESRQKNV NGKAENLELK VASNSLNKPV AQPSGKTDIT
1460 1470 1480 1490 1500
KKDSAQKVMS VRPKVEPSMA KMDPAGVNAT QKSSPIKLKA DTFNTAKMEN
1510 1520 1530 1540 1550
KTCTTDSLST CLPSMLNDDI KRRRIADDLS RAVPIRTRPQ LPAIFRQARK
1560 1570 1580 1590 1600
DGEDVTRRAY SEVVKQKNST PKEVVVPRVV SEIQADPVPA DPQNISLWCQ
1610 1620 1630 1640 1650
FSPIPPEATI KWTKEAAVLS EINKVEKEDG RFTLTIIKAC SKDLGFYKCS
1660 1670 1680 1690 1700
LIVANISVST SEYHLTSEVL MELVIPSHDQ PAEPRVMEGD EENIQCSPLL
1710 1720 1730 1740 1750
FKEDFLSDQY FGKNQPASIL TEKVHFGEGM HRKAFRTTLT EGNLPRFRPG
1760 1770 1780 1790 1800
HPCVLKVHNS ISYGTKNNEE LVQKNYSLAV EECHVQNTAR EYIKAYNSVA
1810 1820 1830 1840 1850
KSAESFGDLP EIIPIYLVHR PSNDIPYATL EEELLGDFVK YSVKDGKEIN
1860 1870 1880 1890 1900
LMRRDSEAGQ KCCAFQHWVY TQTEGNLLVT DMQGVGMKLT DVGIATCKKG
1910 1920 1930 1940 1950
YKGFRGNCAT SFIDQFKALH QCNRYCELLG LVSLQPKPKR TVAPPKPKTQ
1960
PVPKKKTFGP VLNAKS
Length:1,966
Mass (Da):217,128
Last modified:October 16, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BC7FADB5B8DB844
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX248399 Genomic DNA No translation available.
CR925730 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017208526.1, XM_017353037.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
559835

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248399 Genomic DNA No translation available.
CR925730 Genomic DNA No translation available.
RefSeqiXP_017208526.1, XM_017353037.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF1QU13

Genome annotation databases

GeneIDi559835

Organism-specific databases

ZFINiZDB-GENE-030131-1868 alpk2

Phylogenomic databases

eggNOGiENOG410IHFU Eukaryota
ENOG410Y8B3 LUCA
OMAiVSTSEYH

Gene expression databases

BgeeiENSDARG00000079637 Expressed in 12 organ(s), highest expression level in muscle tissue

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALPK2_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QU13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2019
Last sequence update: October 16, 2019
Last modified: November 13, 2019
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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