UniProtKB - F1QSR7 (F1QSR7_DANRE)
Protein
Pannexin
Gene
panx1b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Structural component of the gap junctions and the hemichannels.UniRule annotation
GO - Molecular functioni
- channel activity Source: ZFIN
- voltage-gated channel activity Source: ZFIN
- wide pore channel activity Source: ZFIN
GO - Biological processi
- cation transport Source: GO_Central
- cell-cell signaling Source: GO_Central
- positive regulation of interleukin-1 production Source: InterPro
Keywordsi
Molecular function | Ion channelUniRule annotation |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-DRE-112303, Electric Transmission Across Gap Junctions R-DRE-844456, The NLRP3 inflammasome |
Names & Taxonomyi
Protein namesi | Recommended name: PannexinUniRule annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-070705-192, panx1b |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- gap junction UniRule annotationARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: ZFIN
Other locations
- cytoplasmic vesicle Source: ZFIN
- gap junction Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
- perinuclear region of cytoplasm Source: ZFIN
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 37 – 55 | HelicalPROSITE-ProRule annotationAdd BLAST | 19 | |
Transmembranei | 107 – 126 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Transmembranei | 205 – 227 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Transmembranei | 263 – 287 | HelicalPROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
Cell junction, Gap junctionPROSITE-ProRule annotationARBA annotation, MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineUniRule annotation | 1 | |
Glycosylationi | 246 | N-linked (GlcNAc...) asparagineUniRule annotation | 1 |
Keywords - PTMi
GlycoproteinUniRule annotationARBA annotationProteomic databases
PaxDbi | F1QSR7 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000014910, Expressed in retina and 15 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the pannexin family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | ENOG502QT58, Eukaryota |
GeneTreei | ENSGT00940000153972 |
HOGENOMi | CLU_050054_1_0_1 |
InParanoidi | F1QSR7 |
OMAi | GTQITCF |
OrthoDBi | 623546at2759 |
PhylomeDBi | F1QSR7 |
TreeFami | TF333142 |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin IPR039099, Pannexin |
PANTHERi | PTHR15759, PTHR15759, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1QSR7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIARVATEY VFSDFLLKEQ SDSKYKGVRL ELATDKLVSF IAVGLPLLLI
60 70 80 90 100
SLAFAQEVSV GTQITCFPPT NFTMRQAAYA DSFCWAAVEH HPSENETYSA
110 120 130 140 150
PLHLHKFFPY ILLLLAILMY IPALFWRFTA APSLSSDLSF IMEELDRCYN
160 170 180 190 200
RAIRLAKSIT TKQDKDIAED PHSGLELTEA CFKYPLVEQY LKTKRSSWAL
210 220 230 240 250
AAKYLLCRVL TFLTLLLGCF YLTYYIFWVS PSDQFSCHLR RGILVNQSEV
260 270 280 290 300
PDVVQCKLVA VGVFRLLSCM NLVVYLLLVP AVVYAGLQPA RQHQRGQFLR
310 320 330 340 350
PYHLLPAFGH VLDLQPATRR YDDLSIYLLF LEENLSELKS YKCLQVLELL
360 370 380 390 400
SEGGEAAFDT MCLLRTLGQV KTDMVDKRQA QTVNGNPEIV ISEIKDVSVL
410 420
LDDGVQADKS CSCVKDVRQR VV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Q2M0 | A0A2R8Q2M0_DANRE | Pannexin | panx1b PANX | 354 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465852 Genomic DNA No translation available. |
RefSeqi | NP_001093500.1, NM_001100030.1 |
Genome annotation databases
Ensembli | ENSDART00000097738; ENSDARP00000088509; ENSDARG00000014910 |
GeneIDi | 567417 |
KEGGi | dre:567417 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465852 Genomic DNA No translation available. |
RefSeqi | NP_001093500.1, NM_001100030.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000088509 |
Proteomic databases
PaxDbi | F1QSR7 |
Genome annotation databases
Ensembli | ENSDART00000097738; ENSDARP00000088509; ENSDARG00000014910 |
GeneIDi | 567417 |
KEGGi | dre:567417 |
Organism-specific databases
CTDi | 567417 |
ZFINi | ZDB-GENE-070705-192, panx1b |
Phylogenomic databases
eggNOGi | ENOG502QT58, Eukaryota |
GeneTreei | ENSGT00940000153972 |
HOGENOMi | CLU_050054_1_0_1 |
InParanoidi | F1QSR7 |
OMAi | GTQITCF |
OrthoDBi | 623546at2759 |
PhylomeDBi | F1QSR7 |
TreeFami | TF333142 |
Enzyme and pathway databases
Reactomei | R-DRE-112303, Electric Transmission Across Gap Junctions R-DRE-844456, The NLRP3 inflammasome |
Gene expression databases
Bgeei | ENSDARG00000014910, Expressed in retina and 15 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin IPR039099, Pannexin |
PANTHERi | PTHR15759, PTHR15759, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1QSR7_DANRE | |
Accessioni | F1QSR7Primary (citable) accession number: F1QSR7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | January 20, 2016 | |
Last modified: | April 7, 2021 | |
This is version 63 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |