Methyl-CpG-binding domain protein 3b

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• definitive hemopoiesis Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A network of epigenetic regulators guides developmental haematopoiesis in vivo."
    Huang H.T., Kathrein K.L., Barton A., Gitlin Z., Huang Y.H., Ward T.P., Hofmann O., Dibiase A., Song A., Tyekucheva S., Hide W., Zhou Y., Zon L.I.
    Nat Cell Biol 15:1516-1525(2013) [PubMed] [Europe PMC] [Abstract]
• hematopoietic progenitor cell differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "A network of epigenetic regulators guides developmental haematopoiesis in vivo."
    Huang H.T., Kathrein K.L., Barton A., Gitlin Z., Huang Y.H., Ward T.P., Hofmann O., Dibiase A., Song A., Tyekucheva S., Hide W., Zhou Y., Zon L.I.
    Nat Cell Biol 15:1516-1525(2013) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
XLVVAESQDP TSPSPQRNQT ITGLLECRKK DESKLIKHLI TDVRAESVLS 
        60         70         80         90        100
SSPGLVARVL FLCVRQVDCS GDQARVKGLC SAVVSGIKTA LKKHGNDLDM 
       110        120        130        140        150
TAVWLKNSYV LRDLLLQHSP RQESRGSEDL LPLVTDVQEF VRALSDLCIQ 
       160        170        180        190        200
SYQQLLSISE SRLQPIIIPA MLESEMIPGL AGSSVKLSAA RKRAGSDPRP 
       210        220        230        240        250
PGGSEGVSMS SVLRELSALH TALSRQHLPS VLQEQAFHQL VYLLSASTLN 
       260        270        280        290        300
SLLLRKDMCC WSRGLQIRYN VSVLEEWLRA RSLQTGGAVG TLEPLIQAAQ 
       310        320        330        340        350
LLQMSKKTEA DAQAMVQACS ALTNQQMVKI LSLYTPQSDL EERVTLNFIR 
       360        370        380        390        400
LVQGRSEGPP QLLLDVRRVF PVTFPHDPPA QVTAEQMQIP EALKINFLRR 

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Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ