UniProtKB - F1QMW7 (F1QMW7_DANRE)
Protein
Ataxin-7-like protein 3
Gene
atxn7l3a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 84 – 105 | SGF11-typeUniRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- transcription coactivator activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- histone deubiquitination Source: UniProtKB-UniRule
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, Chromatin regulatorUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Ataxin-7-like protein 3UniRule annotationAlternative name(s): SAGA-associated factor 11 homologUniRule annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030616-253, atxn7l3a |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- DUBm complex Source: UniProtKB-UniRule
- SAGA complex Source: UniProtKB-UniRule
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000029331, Expressed in brain and 30 other tissues |
Interactioni
Subunit structurei
Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 199 – 266 | SCA7InterPro annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 184 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 280 – 367 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 173 | PolyampholyteSequence analysisAdd BLAST | 31 | |
Compositional biasi | 280 – 298 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 330 – 346 | PolarSequence analysisAdd BLAST | 17 |
Domaini
The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.UniRule annotation
The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.UniRule annotation
Sequence similaritiesi
Belongs to the SGF11 family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 84 – 105 | SGF11-typeUniRule annotationAdd BLAST | 22 |
Keywords - Domaini
Zinc-fingerUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000158253 |
HOGENOMi | CLU_066241_0_0_1 |
OMAi | PSNYENM |
TreeFami | TF324580 |
Family and domain databases
HAMAPi | MF_03047, Sgf11, 1 hit |
InterProi | View protein in InterPro IPR013246, SAGA_su_Sgf11 IPR013243, SCA7_dom |
Pfami | View protein in Pfam PF08313, SCA7, 1 hit PF08209, Sgf11, 1 hit |
PROSITEi | View protein in PROSITE PS51505, SCA7, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1QMW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKMEDMSLSG LDNTKLEALA HDVYSDLVED ACLGLCFEVH RAVKQGYFFL
60 70 80 90 100
DETDQESMKD FEIVDQPGVD IFGQVYNQWK NKECVCPNCS RSIAASRFAP
110 120 130 140 150
HLEKCLGMGR NSSRIANRRI ASSNNTSKSE SDQEDNDDIN DNDWSYGSEK
160 170 180 190 200
KAKKRKSEKN PNSPRRSKSL KHKNGELSGG VNPDMYKYNY SSGISYETLG
210 220 230 240 250
PEELRSILTT QCGVVSEHTK KMCTRSQRCP QHTDEQRRAV RVFLLGPSAS
260 270 280 290 300
TLPDADTMLE NEAYEPPDGQ LIMSRLHWDA SSDISPSDSA SSKASTNNSE
310 320 330 340 350
SKRPKKKKPS TLSLTPAGER DKAQERDRIA GSGSSGSSSQ NALGLSSRKK
360
RPKLAVPPAP SIYDDLN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA1L209 | AT7L3_DANRE | Ataxin-7-like protein 3 | atxn7l3 si:dz180g5.4, zgc:136438, zgc:158566 | 367 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX088544 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000104118; ENSDARP00000094893; ENSDARG00000029331 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX088544 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000104118; ENSDARP00000094893; ENSDARG00000029331 |
Organism-specific databases
ZFINi | ZDB-GENE-030616-253, atxn7l3a |
Phylogenomic databases
GeneTreei | ENSGT00940000158253 |
HOGENOMi | CLU_066241_0_0_1 |
OMAi | PSNYENM |
TreeFami | TF324580 |
Gene expression databases
Bgeei | ENSDARG00000029331, Expressed in brain and 30 other tissues |
Family and domain databases
HAMAPi | MF_03047, Sgf11, 1 hit |
InterProi | View protein in InterPro IPR013246, SAGA_su_Sgf11 IPR013243, SCA7_dom |
Pfami | View protein in Pfam PF08313, SCA7, 1 hit PF08209, Sgf11, 1 hit |
PROSITEi | View protein in PROSITE PS51505, SCA7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1QMW7_DANRE | |
Accessioni | F1QMW7Primary (citable) accession number: F1QMW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | April 7, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |