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UniProtKB - F1QM25 (F1QM25_DANRE)

Entry version 74 (07 Oct 2020)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

Collagen, type XV, alpha 1b

Gene

col15a1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type XV, alpha 1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col15a1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070912-689, col15a1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501532602318 – 1245Sequence analysisAdd BLAST1228

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000061848, Expressed in camera-type eye and 65 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F1QM25, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 222LAM_G_DOMAINInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni222 – 680DisorderedSequence analysisAdd BLAST459
Regioni755 – 975DisorderedSequence analysisAdd BLAST221
Regioni1022 – 1046DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi223 – 238PolyampholyteSequence analysisAdd BLAST16
Compositional biasi249 – 265PolyampholyteSequence analysisAdd BLAST17
Compositional biasi302 – 322PolyampholyteSequence analysisAdd BLAST21
Compositional biasi327 – 341Pro-richSequence analysisAdd BLAST15
Compositional biasi413 – 430Pro-richSequence analysisAdd BLAST18
Compositional biasi455 – 481Pro-richSequence analysisAdd BLAST27
Compositional biasi545 – 564Pro-richSequence analysisAdd BLAST20
Compositional biasi597 – 613Pro-richSequence analysisAdd BLAST17
Compositional biasi815 – 829Pro-richSequence analysisAdd BLAST15
Compositional biasi834 – 848PolarSequence analysisAdd BLAST15
Compositional biasi914 – 941Pro-richSequence analysisAdd BLAST28
Compositional biasi953 – 967Pro-richSequence analysisAdd BLAST15
Compositional biasi1024 – 1038PolarSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164061

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F1QM25

Database of Orthologous Groups

More...OrthoDBi		1362001at2759

TreeFam database of animal gene trees

More...TreeFami		TF315821

Family and domain databases

Conserved Domains Database

More...CDDi		cd00247, Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR001791, Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391, Collagen, 7 hits
PF06482, Endostatin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1QM25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFSLLSWLV GAHLALGYLS SALHVMEERG SKGHLILTDL VGMPLPPSVS 
        60         70         80         90        100
FITGYEGYPA YSFGPHANVG RLTQSFVPEP FFTDFAIIVT VKPSSSRGGV 
       110        120        130        140        150
LFAITDPSQT IVQLGLALTP VEDQTQRIVL YYSEPRSANS AEVASFKVPD 
       160        170        180        190        200
MTQQWSRFTL SVERQEVRLY MDCDEYHIAP FKRSQQPLSF KPGSGIFVAN 
       210        220        230        240        250
AGSTGLERFV GSIQQLVIKP DPRAAEEQCE EDDPSLQASG DRSGDGDYDD 
       260        270        280        290        300
EEEHARREET FGQTNNKEKT LRPTSPVEAP PIQSPDIEEG GFSGHVTPID 
       310        320        330        340        350
ERLLRGTYKT DETGERVGQK GERGEPGPAG PPGPPGPPGT SVPIRHSGQP 
       360        370        380        390        400
GPRGPQGPIG QPGGRGRPGK DGQPGSKGED GKPGQRGQTG PPGLPGESGV 
       410        420        430        440        450
KGEKGDPGVG RTGLPGPPGP PGPPGPSKPV KVPYGFDALG SGFGDADIDT 
       460        470        480        490        500
ELLRGPPGPP GPPGIPGPPG PNSPLGGLLP GPPGAPGKDG RDGQSGLPGV 
       510        520        530        540        550
PGQDGLPGQQ GPKGAKGEHG IRGPPGPKGE NGDPGQRGPP GPFGTMGPRG 
       560        570        580        590        600
LPGPPGPPGP PGPINNNFMV DTLKDFEGSG ESGSFLGTGI LKGYQGPPGL 
       610        620        630        640        650
PGPPGPQGPP GANGPPGLSV KGERGSPGPD GIHGLAGLPG ARGPKGDKGN 
       660        670        680        690        700
PGEKGERGRD GLNITGPPGP PGPPGPIINF QDLFLNDTAA KLNLTKIRGL 
       710        720        730        740        750
PGPMGPEGLP GRAGFPGPRG PKGEIGFPGV QGPPGLKGDK GEPGVSIAAD 
       760        770        780        790        800
GSIITSLRGP RGPKGTKGDI GLAGPHGIPG PIGPPGLKGG YGIPGRPGRP 
       810        820        830        840        850
GIAGRKGDKG DASGPSGPPG PPGPPGPPGR VIGLNGVNNN NSQQGVKGEK 
       860        870        880        890        900
GDEGNPGLSG TPVPHAYVGP KGDNGYNGQK GEKGDPGLPG PPGLPGRTGL 
       910        920        930        940        950
VGPKGESIVG PPGDTGAPGP PGLPGYGSPG PQGPPGAPGP PGTSSLYSSA 
       960        970        980        990       1000
ASLPGPPGPP GPPGAPGYGN PVSTYKNSQT LMRESSQAAE GTMGYVIDKS 
      1010       1020       1030       1040       1050
ELYIRVRGGW KKIELGELIP VPEDSSSSAL SQGLSRPSDR SVPRVHSQEL 
      1060       1070       1080       1090       1100
KSFLPGYNLL PDTTHSMPAL HLVALNAPFS GDMHGIRGAD YQCYQQARAR 
      1110       1120       1130       1140       1150
GLTSTYRAFL SSHLQDLSTI VKKADRFNLP VVNLKGEVLF SSWMAMFSGN 
      1160       1170       1180       1190       1200
GGVFDPLTPI YSFDGRNVLT DQAWSQKLVW HGSSTVGIRM TTNYCEAWRT 
      1210       1220       1230       1240 
GDMAVTGQAS LLQTGRLLGQ HTRSCSNHFI ILCIENSYIQ HPGRN
Length:1,245
Mass (Da):127,477
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65A506EE2B59F584
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QT12F1QT12_DANRE
Collagen, type XV, alpha 1b
col15a1b
1,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QFF2A0A2R8QFF2_DANRE
Collagen, type XV, alpha 1b
col15a1b
1,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX511097 Genomic DNA No translation available.
CR788285 Genomic DNA No translation available.
CU467838 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000088643; ENSDARP00000083076; ENSDARG00000061848

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511097 Genomic DNA No translation available.
CR788285 Genomic DNA No translation available.
CU467838 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000088643; ENSDARP00000083076; ENSDARG00000061848

Organism-specific databases

ZFINiZDB-GENE-070912-689, col15a1b

Phylogenomic databases

GeneTreeiENSGT00940000164061
InParanoidiF1QM25
OrthoDBi1362001at2759
TreeFamiTF315821

Gene expression databases

BgeeiENSDARG00000061848, Expressed in camera-type eye and 65 other tissues
ExpressionAtlasiF1QM25, baseline and differential

Family and domain databases

CDDicd00247, Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01391, Collagen, 7 hits
PF06482, Endostatin, 2 hits
SMARTiView protein in SMART
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QM25_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QM25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 20, 2018
Last modified: October 7, 2020
This is version 74 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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