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Entry version 79 (02 Jun 2021)
Sequence version 1 (03 May 2011)
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Protein

Histone-lysine N-methyltransferase

Gene

kmt2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei4089S-adenosyl-L-methionineUniRule annotation1
Binding sitei4091S-adenosyl-L-methionineUniRule annotation1
Binding sitei4133S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4159ZincUniRule annotation1
Metal bindingi4207ZincUniRule annotation1
Binding sitei4208S-adenosyl-L-methionineUniRule annotation1
Metal bindingi4209ZincUniRule annotation1
Metal bindingi4214ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1312 – 1360CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DRE-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kmt2aImported
Synonyms:mllImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-080521-3, kmt2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QL52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000004537, Expressed in multi-cellular organism and 47 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1QL52, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000095298

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1312 – 1360CXXC-typeInterPro annotationAdd BLAST49
Domaini1625 – 1676PHD-typeInterPro annotationAdd BLAST52
Domaini1673 – 1727PHD-typeInterPro annotationAdd BLAST55
Domaini1744 – 1801Phorbol-ester/DAG-typeInterPro annotationAdd BLAST58
Domaini1760 – 1821PHD-typeInterPro annotationAdd BLAST62
Domaini1898 – 1942BromoInterPro annotationAdd BLAST45
Domaini2065 – 2173PHD-typeInterPro annotationAdd BLAST109
Domaini2213 – 2269FYR N-terminalInterPro annotationAdd BLAST57
Domaini3916 – 3997FYR C-terminalInterPro annotationAdd BLAST82
Domaini4079 – 4195SETInterPro annotationAdd BLAST117
Domaini4203 – 4219Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni72 – 234DisorderedSequence analysisAdd BLAST163
Regioni256 – 370DisorderedSequence analysisAdd BLAST115
Regioni481 – 528DisorderedSequence analysisAdd BLAST48
Regioni563 – 657DisorderedSequence analysisAdd BLAST95
Regioni672 – 719DisorderedSequence analysisAdd BLAST48
Regioni814 – 847DisorderedSequence analysisAdd BLAST34
Regioni875 – 937DisorderedSequence analysisAdd BLAST63
Regioni991 – 1186DisorderedSequence analysisAdd BLAST196
Regioni1202 – 1236DisorderedSequence analysisAdd BLAST35
Regioni1269 – 1328DisorderedSequence analysisAdd BLAST60
Regioni1365 – 1587DisorderedSequence analysisAdd BLAST223
Regioni1860 – 1901DisorderedSequence analysisAdd BLAST42
Regioni2305 – 2524DisorderedSequence analysisAdd BLAST220
Regioni2558 – 2578DisorderedSequence analysisAdd BLAST21
Regioni2611 – 2688DisorderedSequence analysisAdd BLAST78
Regioni2706 – 2868DisorderedSequence analysisAdd BLAST163
Regioni2903 – 2942DisorderedSequence analysisAdd BLAST40
Regioni3009 – 3093DisorderedSequence analysisAdd BLAST85
Regioni3235 – 3321DisorderedSequence analysisAdd BLAST87
Regioni3492 – 3518DisorderedSequence analysisAdd BLAST27
Regioni3757 – 3913DisorderedSequence analysisAdd BLAST157
Regioni4037 – 4063DisorderedSequence analysisAdd BLAST27
Regioni4156 – 4157S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3933 – 3953Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 106Polar residuesSequence analysisAdd BLAST35
Compositional biasi150 – 165Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi197 – 213Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi220 – 234Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi294 – 308Polar residuesSequence analysisAdd BLAST15
Compositional biasi315 – 345Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi489 – 511Polar residuesSequence analysisAdd BLAST23
Compositional biasi563 – 621Polar residuesSequence analysisAdd BLAST59
Compositional biasi672 – 689Polar residuesSequence analysisAdd BLAST18
Compositional biasi690 – 704Pro residuesSequence analysisAdd BLAST15
Compositional biasi875 – 899Polar residuesSequence analysisAdd BLAST25
Compositional biasi907 – 937Polar residuesSequence analysisAdd BLAST31
Compositional biasi996 – 1019Polar residuesSequence analysisAdd BLAST24
Compositional biasi1029 – 1070Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1133 – 1158Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1164 – 1179Polar residuesSequence analysisAdd BLAST16
Compositional biasi1383 – 1397Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1408 – 1423Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1424 – 1445Polar residuesSequence analysisAdd BLAST22
Compositional biasi1455 – 1501Polar residuesSequence analysisAdd BLAST47
Compositional biasi1520 – 1539Polar residuesSequence analysisAdd BLAST20
Compositional biasi1566 – 1583Polar residuesSequence analysisAdd BLAST18
Compositional biasi2365 – 2419Polar residuesSequence analysisAdd BLAST55
Compositional biasi2431 – 2450Polar residuesSequence analysisAdd BLAST20
Compositional biasi2457 – 2475Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2476 – 2493Polar residuesSequence analysisAdd BLAST18
Compositional biasi2558 – 2575Polar residuesSequence analysisAdd BLAST18
Compositional biasi2621 – 2646Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi2647 – 2688Polar residuesSequence analysisAdd BLAST42
Compositional biasi2744 – 2758Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2759 – 2810Polar residuesSequence analysisAdd BLAST52
Compositional biasi2811 – 2832Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2840 – 2860Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi2903 – 2917Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3018 – 3039Polar residuesSequence analysisAdd BLAST22
Compositional biasi3040 – 3056Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3077 – 3093Polar residuesSequence analysisAdd BLAST17
Compositional biasi3248 – 3263Polar residuesSequence analysisAdd BLAST16
Compositional biasi3300 – 3321Polar residuesSequence analysisAdd BLAST22
Compositional biasi3495 – 3518Polar residuesSequence analysisAdd BLAST24
Compositional biasi3757 – 3779Polar residuesSequence analysisAdd BLAST23
Compositional biasi3799 – 3815Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3816 – 3868Polar residuesSequence analysisAdd BLAST53
Compositional biasi4040 – 4056Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1312 – 1360CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1084, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QL52

Database of Orthologous Groups

More...
OrthoDBi
738155at2759

TreeFam database of animal gene trees

More...
TreeFami
TF319820

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
cd15592, PHD3_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR044133, KMT2A_PHD3
IPR016569, MeTrfase_trithorax
IPR002219, PE/DAG-bd
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 1 hit
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1QL52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGGSSSSG TGRKAGRIRV NASLLISAGT NPNANGLGPG
60 70 80 90 100
FDAALQVSAA IGSNLQKFRD VLGESSGSSS GEEEFGGFTT VSDNRRLHSP
110 120 130 140 150
GRTSIGSITP DKKPRGRPPR TPAVQRVGTD TETAPLPVAT SPTEKLKRQP
160 170 180 190 200
GRPPGTREKK RGRPPASVSQ RTWQHSGHAL PEEGREVPQE CSSSPVHSKE
210 220 230 240 250
GVEENKEKRQ TPLGSGHHQG SEAKLHKVSR ESKVTKLKRL REVKLSPLKS
260 270 280 290 300
KLKAIVRKTV TVPGKQRRKR GRPPSAERLK AEAAAAAAAA QAANASMAQE
310 320 330 340 350
TSTTAPRTAK KKAFRVRRSQ DLGARTPHEL RASHTADEHT HSDSQDSPTA
360 370 380 390 400
ADPLTPTKVG RPLGLRQSPR HIKPVRVVPP SKRTDATIAK QLLQRAKKGA
410 420 430 440 450
QKKKLLEKDS VGTQGKAGLE AGKHRRRTQL TNIRQFIMPV VSTVSLRIIK
460 470 480 490 500
TPKRFIEDEG SFSTPPPHMK IARLESALTA PAPQPATPST PALVSTAPST
510 520 530 540 550
SGTTATPGSG SAVESLPPPP PPVSTGSTTA IAASLLNSSC NNSTSNGRFS
560 570 580 590 600
SSAASCGSSA VSQHSSQLSS GESSRSTSPS LDDSSCDSQA SEGTQALSEE
610 620 630 640 650
ADHSPASQGE TEASLHHASH PPSPTSEPEP DHIVLEHSRR GRRGQSHRRG
660 670 680 690 700
AVVARGRGNL IIGRKQAIIS PATGVSQAGS QQASSTASSS SSPPPPPLLS
710 720 730 740 750
PPQPPQTASS NAAEHHSHSP WMMSHSIAPF LPTSSILSSS HDKRRSILRE
760 770 780 790 800
PTFRWTSLSC AENKYFSSAK YAKEGLIRKP TFDNFRPPPL TAEDVGLMPP
810 820 830 840 850
VTGGGGVTSG GFPAPGGAAG TGTRLFSPLH HHPHHNHHQH SSSRFETPLQ
860 870 880 890 900
KRTPLLRPPF FTPSPAHSRI FESVTLPSSS GSSPGSLSPL QVSPTSSKKK
910 920 930 940 950
KGSRFSRGQP RSPSHSMITR SSQSGVPTGK SSEQSIISSS VPITVTGNSS
960 970 980 990 1000
PLPGVAVSPL AASALTQASF SGFPSGSIGL TSHGVSDGRR AAGGLSVSGN
1010 1020 1030 1040 1050
SASSSQLFPL FTPSPQASGG GTGKAGKERG ISATRDTGTK EKDREMEKSR
1060 1070 1080 1090 1100
EREKENKRDG RRDWDKRGKS LPSEASPSSI SSFFGLEAIE ESLTQKRTPG
1110 1120 1130 1140 1150
RKKSVTVDCA EASPSDSAAV QAVGSLSSKG RLTKKGRPPE KSIESEGVER
1160 1170 1180 1190 1200
EKDKEKLSAL TQAGQMGKPP TTTSIDSILD RAEKQPVTDR RVVRLLKKAK
1210 1220 1230 1240 1250
AQLNKIEKRE LQPGDQPKLP GQESDSSETS VRGPRIKHVC RRAAVALGRN
1260 1270 1280 1290 1300
RAVFPDDMPT LSALPWEERE KILSSMGNDD KSSVAGSEEA EPPTPPIKPV
1310 1320 1330 1340 1350
TRQKTVHEAP PRKGRRSRRC GQCPGCQVPN DCGVCTNCLD KPKFGGRNIK
1360 1370 1380 1390 1400
KQCCKVRKCQ NLQWMPSKFL QKQAKGKKDR RRNKLSEKKE LHHKSQCSEA
1410 1420 1430 1440 1450
SPKSVPPPKD EPPRKKSETP PPAQGDDKQK QTQPSSPSSP ASSPKDPLLS
1460 1470 1480 1490 1500
SPPDDHKHSL TSLSSACRKE RKQQPSSSPT FLHAAPSSPP AQSQHSLQQP
1510 1520 1530 1540 1550
CQMPAKKEGL TKSQSHTEPK KKSQQQSQPS SATDTAPDAK LKKQTTRCVQ
1560 1570 1580 1590 1600
PLKPKPKEKE KQLPKPDSST LNSQSTPSTG GTAKQKAPYD GVHRIRVDFK
1610 1620 1630 1640 1650
EDYNIENVWE MGGLSILTSV PITPRVVCFL CASSGNVEFV FCQVCCEPFH
1660 1670 1680 1690 1700
LFCLGEAERP HDEQWENWCC RRCRFCHVCG RKYQKTKQLL ECDKCRNSYH
1710 1720 1730 1740 1750
PECLGPNHPT RPTKKKRVWV CTKCVRCKSC GATKPGKAWD AQWSHDFSLC
1760 1770 1780 1790 1800
HDCAKRLTKG NLCPLCNKGY DDDDCDSKMM KCKKCDRWVH AKCESLTDDM
1810 1820 1830 1840 1850
CELMSSLPEN VVYTCTNCTE SHPAEWRTVL EKEIQRSMRQ VLTALFNSRT
1860 1870 1880 1890 1900
STHLLRYRQA VMKPPELNPE TEESLPSRRS PEGPDPPVLT EVSPPNDSPL
1910 1920 1930 1940 1950
DLESVEKKMD SGCYKSVLEF SDDIVKIIQT AFNSDGGQLE SRKANSMLKS
1960 1970 1980 1990 2000
FFIRQMERIF PWYKVKESKF WETSKASSNS GLLPNVVLPP SLDHNYAQCQ
2010 2020 2030 2040 2050
EREEIAKAGQ SVHMKKIIPA PHPKAPGEPN SLMAPTPPPP PPMLIHDHSL
2060 2070 2080 2090 2100
EDSPVIPPPP GVGDNRQCAL CLNYGDEKTN DCGRLLYIGH NEWAHVNCAL
2110 2120 2130 2140 2150
WSAEVYEDVD GALKNVHMAV SRGKQLQCKN CHKPGATVSC CMTSCTNNYH
2160 2170 2180 2190 2200
FMCARQQQCA FLEDKKVYCQ HHKDLVKGEV VPESSFEVTR RVLVDFEGIR
2210 2220 2230 2240 2250
LRRKFVNGLE PDNIHMVIGS MTIDCLGMLT ELSDCERKLF PVGYQCSRVY
2260 2270 2280 2290 2300
WSTLDARKRC VYKCRILVCR PPLSETLNKN IAAQEENHTV VHSPPPVSAV
2310 2320 2330 2340 2350
DTFLPGPIDS TKPSNVPSTP KPRVYFRNRH PSFPPCHRSP STRPLPSPDG
2360 2370 2380 2390 2400
FNNTGHEIVT VGDPLLSSSL RSIGSRRHST SSISAQQPRQ KVSSPPQGGT
2410 2420 2430 2440 2450
VYSQTGNSSA SFMSSTSKEP LTKDTDKGRV SSGETSFSRE PNSINIGAQR
2460 2470 2480 2490 2500
RLSFGFTERV DGSKEATKKH SDGESLKSSQ PASVSQVSPP LGTAVLTGHQ
2510 2520 2530 2540 2550
RASGGIKNEK GKQATKDNDL PAGATFMSSH PLAMLPKDKA NPNKEGNMTS
2560 2570 2580 2590 2600
MAALKDTVKT GSPQRIYNKS GSRKSHDYAS GPAAVVAMKP LWSSGAKLGE
2610 2620 2630 2640 2650
EDIKRGFQAS AGITGSHGTS STKEKHSKVK MNVSRDVSKE RKETPQNRNA
2660 2670 2680 2690 2700
VLNSNSKSSN VKTQGQVPPP HNISNKATAL SSNTGSGTVE VNKFDQKEVE
2710 2720 2730 2740 2750
KPLKSKERFS FEKKHTSAMD AIQPKAGSER SIRPPQVHPK SSKEVPLVGK
2760 2770 2780 2790 2800
KHTERLSLMS QKMDPNRTKA VSISPNTQTY TSVTPSNQGP QRRSSRAMVF
2810 2820 2830 2840 2850
SPSASSESSE SDSHIHPDDS EEHLMDHQCA DDGEDNNLED EGSVDKHHEE
2860 2870 2880 2890 2900
DSDGSAGSAK RRYPRRSARA RSNMFFGLTP FYGVRSYGEE DIPFYRSGEI
2910 2920 2930 2940 2950
SMKKRTGSSK RSAEGQVDGA DDMSTSSSAD SGEDEEGGIG SNKDTYYYNF
2960 2970 2980 2990 3000
TRTIINPSSG LPSIAGIDQC LGRGSQIHRF LRDQAKEHED DSDEVSTATK
3010 3020 3030 3040 3050
NLELQQIGQL DGVDDGSESD ISISTSSTTT ATTSSTQKGS TKRKGRESRT
3060 3070 3080 3090 3100
EKSNVDSGKE AVNTTSNSRD SRKNQKDNCL PLGSVKTQGQ DPLETQLSLT
3110 3120 3130 3140 3150
TDLLKSDSDN NNSDDCGNIL PSDIMEFVLN TPSMQALGQQ AEAPSAEQFS
3160 3170 3180 3190 3200
LDESYGVDVN QRKDMLFEDF TQPLANAESG ESGVSTTIAV EESYGLPLEL
3210 3220 3230 3240 3250
PSDLSVLTTR SPTVSNQNHG PLISETSERT MLALATEESE AGKSKKKTRT
3260 3270 3280 3290 3300
GSTVSSKSPQ EGCADSQVPE GHMTPEHFIP PSVDGDHITS PGVAPVGETG
3310 3320 3330 3340 3350
NQDMTRTSST PVLPSSPTLP LQNQKFIPAT TVTSGPAPIT SSAVQAAASQ
3360 3370 3380 3390 3400
LKPGPEKLIV LNQHLQPLYV LQTVPNGVMN PNAPVLTGLS GGISTSQSIF
3410 3420 3430 3440 3450
PAGSKGLVPV SHHPQIHAFT GTTQTGFQPV IPSTTSGLLI GVTSHDPQIG
3460 3470 3480 3490 3500
VTEAGHRHDH APNVAMVSSA STITPAPSMI PSGHGKKRLI SRLQSPKSKK
3510 3520 3530 3540 3550
QARPKTQPTL APSDVGPNMT LINLSPSQIA AGIPAQTGLM ELGTITATPH
3560 3570 3580 3590 3600
RKIPNIIKRP KQGVMYLEPT ILPQPMPIST TTQPGILGHD SSTHLLPCTV
3610 3620 3630 3640 3650
SGLNTSQSVL NVVSVPSSAP GNFLGGSSVS LSAPGLISST EITGSLSNLL
3660 3670 3680 3690 3700
IKANPHNLSL SEQPMVLHPG TPMMSHLTNP AQTSIASSIC VFPPNQSITV
3710 3720 3730 3740 3750
PVNQQVEKEG TVHLQHAVSR VLADKTLDPN VSSAGQVALA PNPISQELNK
3760 3770 3780 3790 3800
GHVVSVLTQS SRTSPISRPQ HQHQASKLPA GASSVAFGKG KHKAKRPRPC
3810 3820 3830 3840 3850
PDKSSGKKHK GLHSDTPTVD TSAIQLSYIK GDQELSSPEP MDTGQSNETG
3860 3870 3880 3890 3900
SKKRDSTTMT TNSSALKRKT VDAVDEKPST AGLPSKGDGT GNKAFSVDTP
3910 3920 3930 3940 3950
DQRDSGRDSS LDHKPKKGLI FEICSDDGFQ IRCESIEEAW KSLTDKVQEA
3960 3970 3980 3990 4000
RSNARLKALS FDGVNGLKML GVVHDAVVFL LEQLYGARHC RNYRFRFHKP
4010 4020 4030 4040 4050
EETDYLPVNP HGSARAEVYH RKSVLDMFNF LASKHRQPPV YNPQEEDEEE
4060 4070 4080 4090 4100
MQQKSARRAT STDLPLPEKF RQLKKASRDA VGVYRSAIHG RGLFCRKNIE
4110 4120 4130 4140 4150
PGEMVIEYSG NVIRSVLTDK REKYYDDKGI GCYMFRIDDY EVVDATIHGN
4160 4170 4180 4190 4200
SARFINHSCE PNCYSRVVNV DGQKHIVIFA TRKIYKGEEL TYDYKFPIEE
4210
PGNKLPCNCG AKKCRKFLN
Length:4,219
Mass (Da):456,723
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA370A338E58B715
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W578F8W578_DANRE
Histone-lysine N-methyltransferase
kmt2a mll
4,218Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CR847979 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_005157640.1, XM_005157583.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSDART00000104525; ENSDARP00000095298; ENSDARG00000004537

Database of genes from NCBI RefSeq genomes

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GeneIDi
557048

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847979 Genomic DNA No translation available.
RefSeqiXP_005157640.1, XM_005157583.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095298

Proteomic databases

PaxDbiF1QL52

Genome annotation databases

EnsembliENSDART00000104525; ENSDARP00000095298; ENSDARG00000004537
GeneIDi557048

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4297
ZFINiZDB-GENE-080521-3, kmt2a

Phylogenomic databases

eggNOGiKOG1084, Eukaryota
GeneTreeiENSGT00940000163756
InParanoidiF1QL52
OrthoDBi738155at2759
TreeFamiTF319820

Enzyme and pathway databases

ReactomeiR-DRE-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DRE-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs

Gene expression databases

BgeeiENSDARG00000004537, Expressed in multi-cellular organism and 47 other tissues
ExpressionAtlasiF1QL52, baseline

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
cd15592, PHD3_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR044133, KMT2A_PHD3
IPR016569, MeTrfase_trithorax
IPR002219, PE/DAG-bd
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 1 hit
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit
PS50016, ZF_PHD_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QL52_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QL52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 2, 2021
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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