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UniProtKB - F1QJP0 (F1QJP0_DANRE)

Entry version 76 (29 Sep 2021)
Sequence version 2 (21 Sep 2011)
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Protein
Submitted name:

Excision repair cross-complementation group 6-like 2

Gene

ercc6l2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Excision repair cross-complementation group 6-like 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ercc6l2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-110411-274, ercc6l2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F1QJP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000012403, Expressed in mature ovarian follicle and 24 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000109375

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 254Helicase ATP-bindingInterPro annotationAdd BLAST183
Domaini449 – 603Helicase C-terminalInterPro annotationAdd BLAST155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni686 – 710DisorderedSequence analysisAdd BLAST25
Regioni734 – 801DisorderedSequence analysisAdd BLAST68
Regioni836 – 868DisorderedSequence analysisAdd BLAST33
Regioni1033 – 1091DisorderedSequence analysisAdd BLAST59
Regioni1243 – 1269DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 29Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi751 – 801Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi836 – 855Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1070 – 1091Basic and acidic residuesSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0387, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000315_17_10_1

Identification of Orthologs from Complete Genome Data

More...OMAi		VAYTHSN

Database of Orthologous Groups

More...OrthoDBi		372069at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		F1QJP0

TreeFam database of animal gene trees

More...TreeFami		TF351516

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10810, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR029256, Heliccase-ass-bd
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
PF14773, VIGSSK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

F1QJP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMNEEKDSS TKCQDARTPL PHFEDEKPLF HSNQTPPGPS EAFLLAGSDV 
        60         70         80         90        100
KVPYTINRYL RDYQREGIKF IYQNYAKSRG CILGDDMGLG KTVQVIGFLA 
       110        120        130        140        150
AVLQKTGTWK DVENNRPQFL LSQKPSERVQ KVFVIVAPLS VLYNWKDELD 
       160        170        180        190        200
TWGHFRVVVV HGVRKDEELA RVQRGRCEIA LTTYETLRLC LDQFNSINWA 
       210        220        230        240        250
AVIVDEAHKI KNHKSKITQA VKQMRCKVRI GLTGTILQNN LEELWCVMNW 
       260        270        280        290        300
AVPRCLGSLG AFKNRFSDPI EKGQKHTVTK RALAEGRKAV QELAKKLSRW 
       310        320        330        340        350
FLRRTKSLIS DQLPKKDDRV VYCSLTDFQR TVYRAVLDSD DVTLMLQSSG 
       360        370        380        390        400
KCPCSSGRPR KKCCYKLNAD GVPVRHLYFS YLAILRKVAN HVALLQSKDG 
       410        420        430        440        450
TSKKQEKYVT TICEQVFRKF PDFTERCKQA AFEAMSDPMY SGKMKVMQKL 
       460        470        480        490        500
LNHFIAKKDK VLLFSLSTKL LDVLESYCMA EGLEYHRLDG NTKSKDRVKI 
       510        520        530        540        550
VKEFNSSRDV NLCLVSTLAG GLGLNFIGAN VVVLFDPTWN PANDLQAIDR 
       560        570        580        590        600
VYRIGQCRDV TVFRLISLGT VEEIIYLRQV YKQQLQSSVI GQENARRYFE 
       610        620        630        640        650
AVQGTDGYAG ELFGIRNLFR LQTDGTCLTH RILEREGQLE VGIMTARTQA 
       660        670        680        690        700
VDERMQEPDP WSADAATERA GGSAGVCIKP AEVLDFSSGS EDEDPCCSKQ 
       710        720        730        740        750
RPSETHSGEQ MVASNTCIGN TGLCNLLQKQ MTEIRQRDTD TEEDSSSESH 
       760        770        780        790        800
DEDDNCEKLT AIKTSKVKDL SSESEEELEG VSDGELQRRS HKDSTKDGKN 
       810        820        830        840        850
HCRKRVKFAE RSEDEIEHFS WSDDEGFLKA VRCVKEKESD HRQSSRRENT 
       860        870        880        890        900
TSGFKKGQSR DEGYTGTLDS LLGGLQQVGY THSNQKVVGS SRAEDRLSRA 
       910        920        930        940        950
AVREVFELHK HSQLPANQIL NVSETESSDP ILTDHVNGGQ TPMTRSRPHI 
       960        970        980        990       1000
EHPVTHTIKT SHRQNNLTVI VGETPSSMCR QQLEEMAQFF GFNSVRDFAE 
      1010       1020       1030       1040       1050
EILKSDSDQR LGRLRSFYSQ KSPELMNIIK KTFPKPNIQP NPPNAPPLSA 
      1060       1070       1080       1090       1100
ARHKPTSKRA HPNSSVEVPT PEAEDRRKTS KKKKTSETEA SKIDLHCSTD 
      1110       1120       1130       1140       1150
LTKTKMKKSS TDISPSSSSG NIPQINCAPV EECIPNITSS SQPCTSRSAC 
      1160       1170       1180       1190       1200
VSTDDCVAST SSQTSSSSKI TDLLGDTSIL NDLFKTKKKV VDQPRDVKTS 
      1210       1220       1230       1240       1250
ACTERAPKRG KDFWDILNEG NEESINKLTN LTEVEKICNS VSVSAKPKSN 
      1260 
GETESSQLWK KNEKFLWKR
Length:1,269
Mass (Da):142,860
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E892E856579CC5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1269Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR376747 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001314698.1, NM_001327769.1
XP_009302339.1, XM_009304064.2
XP_009302340.1, XM_009304065.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000125173; ENSDARP00000109375; ENSDARG00000012403

Database of genes from NCBI RefSeq genomes

More...GeneIDi		553504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:553504

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376747 Genomic DNA No translation available.
RefSeqiNP_001314698.1, NM_001327769.1
XP_009302339.1, XM_009304064.2
XP_009302340.1, XM_009304065.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109375

Proteomic databases

PaxDbiF1QJP0

Genome annotation databases

EnsembliENSDART00000125173; ENSDARP00000109375; ENSDARG00000012403
GeneIDi553504
KEGGidre:553504

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		375748
ZFINiZDB-GENE-110411-274, ercc6l2

Phylogenomic databases

eggNOGiKOG0387, Eukaryota
GeneTreeiENSGT00940000161328
HOGENOMiCLU_000315_17_10_1
OMAiVAYTHSN
OrthoDBi372069at2759
PhylomeDBiF1QJP0
TreeFamiTF351516

Gene expression databases

BgeeiENSDARG00000012403, Expressed in mature ovarian follicle and 24 other tissues

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR029256, Heliccase-ass-bd
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
PF14773, VIGSSK, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QJP0_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QJP0
Secondary accession number(s): F1R460
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: September 21, 2011
Last modified: September 29, 2021
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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