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Protein
Submitted name:

Eph receptor A4,-like

Gene

epha4l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPUniRule annotation1
Active sitei746Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi627 – 635ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-2682334 EPH-Ephrin signaling
R-DRE-3928663 EPHA-mediated growth cone collapse
R-DRE-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Submitted name:
Eph receptor A4,-likeImported
Gene namesi
Name:epha4lImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-990415-61 epha4l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei548 – 572HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500327277422 – 988Sequence analysisAdd BLAST967

Proteomic databases

PaxDbiF1QJD4
PRIDEiF1QJD4

Expressioni

Gene expression databases

BgeeiENSDARG00000010767 Expressed in 15 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003161

Structurei

3D structure databases

ProteinModelPortaliF1QJD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 211Eph LBDInterPro annotationAdd BLAST180
Domaini330 – 440Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini444 – 536Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini621 – 882Protein kinaseInterPro annotationAdd BLAST262
Domaini913 – 977SAMInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
InParanoidiF1QJD4
OMAiVEYWANA
OrthoDBiEOG091G00W0
TreeFamiTF315608

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

F1QJD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALMAGIIYA LTSLFLGICA GLSAPRSPPA NEVTLLDSRS VQGELAWVAS
60 70 80 90 100
PTEGGWEEVS IMDEKNIPIR TYQVCNVMEP SQNNWLRTHW IQRGAAQRIY
110 120 130 140 150
IEIKFTLRDC NSLPGVIGTC KETFNLYYLE SDSDNERYAH ESRFSKIDTV
160 170 180 190 200
AADESFTQVD IGDRIMKLNT EVRDVGVLSR AGFYLAFQDV GACIALVSVH
210 220 230 240 250
VFYKKCPLAV RNLAQFPDTV TGADTSSLVE VRGSCVDHSE EQEVPKMYCG
260 270 280 290 300
ADGEWLVPIG NCLCNPGYEE RIEQCQVCKV GYYRSLSSDV GCRKCPLHSY
310 320 330 340 350
SVKEGATSCD CDKGYYRSET DPAAMPCTRP PSAPHNLISN VNETSVLLDW
360 370 380 390 400
SPPLSSGGRQ DLTYNVVCKQ CVRDTQRCSP CGDDVRYSPQ RLSLRSTRVS
410 420 430 440 450
VHQLQAHTNY TFQIWAINGV SKHNPSPEQA VSVTLTTNQA APSMVMSVQS
460 470 480 490 500
KDITRHTLAL FWDQPEKPNG VILEYEVKYY EKDQNERSYR IVKTTSRNAD
510 520 530 540 550
IKDLTPLTSY VFHVRARTAA GYGDFSAPFE FSTNTVAAPV VGGVMSSAVL
560 570 580 590 600
LLLVAGCVVV LLLILIITFI FTKRRSKYSK TKQGEDKNVQ QGVRIYVDPF
610 620 630 640 650
TYEDPNQAIR EFAKEINTSC IKIEKVIGIG EFGEVCSGRL KLPGKREICV
660 670 680 690 700
AIKTLKAGFT EQQRLDFLSE ASVIGQFDHP NIIHLEGVVT KCKPVMIITE
710 720 730 740 750
YMENGSLDMF LRKNDGRFTV IQLVGILRGI ASGMKYLSDM SYVHRDLAAR
760 770 780 790 800
NILVNSNLVC KVSDFGMSRV LEDEPEGAYT TRGGKIPIRW TAPEAITYRK
810 820 830 840 850
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMECP
860 870 880 890 900
LALHQLMLEC WMRERADRPK FSQIVNMLDK LIRNPATLKR TAGDASRSHP
910 920 930 940 950
STINHAPSEC SAPSLASVDD WLKLIGLEQY RENFNTAGYS SIESVIPMNH
960 970 980
EDLAKMGISC SAHQRKILSS VEDLLSGMHH RQDSKVPV
Length:988
Mass (Da):110,425
Last modified:May 3, 2011 - v1
Checksum:i4362BB61C7A474B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649368 Genomic DNA No translation available.
CR925728 Genomic DNA No translation available.
RefSeqiXP_687698.2, XM_682606.5
UniGeneiDr.88615

Genome annotation databases

EnsembliENSDART00000004338; ENSDARP00000003161; ENSDARG00000010767
GeneIDi30687
KEGGidre:30687

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649368 Genomic DNA No translation available.
CR925728 Genomic DNA No translation available.
RefSeqiXP_687698.2, XM_682606.5
UniGeneiDr.88615

3D structure databases

ProteinModelPortaliF1QJD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003161

Proteomic databases

PaxDbiF1QJD4
PRIDEiF1QJD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000004338; ENSDARP00000003161; ENSDARG00000010767
GeneIDi30687
KEGGidre:30687

Organism-specific databases

CTDi30687
ZFINiZDB-GENE-990415-61 epha4l

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
InParanoidiF1QJD4
OMAiVEYWANA
OrthoDBiEOG091G00W0
TreeFamiTF315608

Enzyme and pathway databases

ReactomeiR-DRE-2682334 EPH-Ephrin signaling
R-DRE-3928663 EPHA-mediated growth cone collapse
R-DRE-3928665 EPH-ephrin mediated repulsion of cells

Gene expression databases

BgeeiENSDARG00000010767 Expressed in 15 organ(s), highest expression level in embryo

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1QJD4_DANRE
AccessioniPrimary (citable) accession number: F1QJD4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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