UniProtKB - F1QIK8 (EMP2_DANRE)
Protein
Epithelial membrane protein 2
Gene
emp2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. May play a role in glomerular filtration (PubMed:24814193).By similarity1 Publication
GO - Biological processi
- positive regulation of cell population proliferation Source: UniProtKB
- regulation of glomerular filtration Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Epithelial membrane protein 2Short name: EMP-2 |
Gene namesi | Name:emp2Imported ORF Names:zgc:100935Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040822-24, emp2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
- Apical cell membrane By similarity
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Other locations
- Membrane raft By similarity
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 67 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 95 – 115 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 137 – 157 | Helical; Name=4Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Golgi apparatus, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430725 | 1 – 161 | Epithelial membrane protein 2Add BLAST | 161 |
Proteomic databases
PaxDbi | F1QIK8 |
Expressioni
Tissue specificityi
Expressed in the arches, orbits, pectoral fins, vessels, pronephric renal tubules, and glomeruli.1 Publication
Gene expression databases
Bgeei | ENSDARG00000044588, Expressed in somite and 35 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the PMP-22/EMP/MP20 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYYE, Eukaryota |
GeneTreei | ENSGT00950000182696 |
HOGENOMi | CLU_138632_0_0_1 |
InParanoidi | F1QIK8 |
OMAi | GSYGYSF |
OrthoDBi | 1345659at2759 |
TreeFami | TF330414 |
Family and domain databases
InterProi | View protein in InterPro IPR003933, EMP-2 IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
PANTHERi | PTHR10671:SF32, PTHR10671:SF32, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01453, EPMEMFAMILY |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit PS01222, PMP22_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1QIK8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVILAFIIL FHITSAILLF IATINNAWRI KGDFSMDLWY NCNTTACYDI
60 70 80 90 100
PKSATYDAAY LQAVQATMIL ATILCCVGFF VFILQLFRLK QGERFVFTAI
110 120 130 140 150
IQLLSAFCVM TGASIYTAEG LTFNGQEFKN AEYGYSFVVA WVAFPMTLLS
160
GLMYLVLRKR K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR954963 Genomic DNA No translation available. |
RefSeqi | XP_017209506.1, XM_017354017.1 |
Genome annotation databases
Ensembli | ENSDART00000065495; ENSDARP00000065494; ENSDARG00000044588 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR954963 Genomic DNA No translation available. |
RefSeqi | XP_017209506.1, XM_017354017.1 |
3D structure databases
SMRi | F1QIK8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000065494 |
Proteomic databases
PaxDbi | F1QIK8 |
Genome annotation databases
Ensembli | ENSDART00000065495; ENSDARP00000065494; ENSDARG00000044588 |
Organism-specific databases
ZFINi | ZDB-GENE-040822-24, emp2 |
Phylogenomic databases
eggNOGi | ENOG502RYYE, Eukaryota |
GeneTreei | ENSGT00950000182696 |
HOGENOMi | CLU_138632_0_0_1 |
InParanoidi | F1QIK8 |
OMAi | GSYGYSF |
OrthoDBi | 1345659at2759 |
TreeFami | TF330414 |
Miscellaneous databases
PROi | PR:F1QIK8 |
Gene expression databases
Bgeei | ENSDARG00000044588, Expressed in somite and 35 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR003933, EMP-2 IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
PANTHERi | PTHR10671:SF32, PTHR10671:SF32, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01453, EPMEMFAMILY |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit PS01222, PMP22_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EMP2_DANRE | |
Accessioni | F1QIK8Primary (citable) accession number: F1QIK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | May 14, 2014 | |
Last modified: | February 10, 2021 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families