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Entry version 71 (25 May 2022)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Gon-4-like (C. elegans)

Gene

gon4lb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Gon-4-like (C. elegans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gon4lbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070117-2447, gon4lb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QI87

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000005867, Expressed in blastula and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000109415

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
F1QI87

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1QI87

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 93DisorderedSequence analysisAdd BLAST93
Regioni253 – 314DisorderedSequence analysisAdd BLAST62
Regioni496 – 523DisorderedSequence analysisAdd BLAST28
Regioni1100 – 1145DisorderedSequence analysisAdd BLAST46
Regioni1209 – 1245DisorderedSequence analysisAdd BLAST37
Regioni1265 – 1550DisorderedSequence analysisAdd BLAST286
Regioni1841 – 1965DisorderedSequence analysisAdd BLAST125
Regioni2031 – 2055DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili142 – 162Sequence analysisAdd BLAST21
Coiled coili545 – 565Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 66Polar residuesSequence analysisAdd BLAST43
Compositional biasi74 – 89Polar residuesSequence analysisAdd BLAST16
Compositional biasi254 – 280Acidic residuesSequence analysisAdd BLAST27
Compositional biasi281 – 296Polar residuesSequence analysisAdd BLAST16
Compositional biasi504 – 519Acidic residuesSequence analysisAdd BLAST16
Compositional biasi1209 – 1229Polar residuesSequence analysisAdd BLAST21
Compositional biasi1265 – 1281Polar residuesSequence analysisAdd BLAST17
Compositional biasi1312 – 1326Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1334 – 1389Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi1390 – 1416Acidic residuesSequence analysisAdd BLAST27
Compositional biasi1436 – 1453Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1454 – 1477Polar residuesSequence analysisAdd BLAST24
Compositional biasi1492 – 1509Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1856 – 1945Basic and acidic residuesSequence analysisAdd BLAST90

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT2W, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164105

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000833_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QI87

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRNYKDC

Database of Orthologous Groups

More...
OrthoDBi
49443at2759

TreeFam database of animal gene trees

More...
TreeFami
TF343327

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1160.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR003822, PAH
IPR036600, PAH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671, PAH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF47762, SSF47762, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477, PAH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1QI87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWKRKSSSP EPQPNLVKLP KRESLSRSPS SWKRKASTPS KTKSWTSIQS
60 70 80 90 100
LSPDRHVDQC NGQEKMSSAG HVEDDSDCIQ SSTPVSSPLR SEEDAELGLV
110 120 130 140 150
ITVDEDRCEG EEWLKKRNGV NIKKNGINQT EGEIPQKEDG DVEKTMEQLS
160 170 180 190 200
EEDENEEELR KLDRDLTLKS KKLNLSSINV RNIIHEVVTN EHVVAMMKAA
210 220 230 240 250
IKETQDMPMF EPKMTRSKLK EAVEKGVGMG NWNISPIKKA NDIKPPQFVD
260 270 280 290 300
IPLQEEEDSS DEEYCPDEDE EDETAEETFL ESDVESTSSS PRGIRRFPSQ
310 320 330 340 350
TPPHCDDASN SPRLKPRLAR HLRVEAVPMG PPAPPPQSCG LSRSLKTLDP
360 370 380 390 400
FIEKLHAVDK ELELSPLCME PYQALSSGGA GEPDDSLVAC RTRSKRPLRD
410 420 430 440 450
VPLDQLEAEL RAPDITPDMY DNVSTPEDRE WTQWLQGLMT SHLDNDEEAD
460 470 480 490 500
EDDDPEYNFL DDLDEPDLED YRNDRAVRIT KKEVNELMEE LFETFHDELA
510 520 530 540 550
ANEPDDEGHD EDEEREEEAN DTPQFNVPQA IRFEEPLAHM LTACRRTVRE
560 570 580 590 600
QLDALQQRRE NQVRTTQHAS GPGMVFVQPS CPLVVTPAQR IQLQQQIQQH
610 620 630 640 650
VQLLTQVSML CDPVGALQTE AQTTKHFLGE LLSFAERAEE ERSAVNLGFK
660 670 680 690 700
SVFRVCNLLS SINLLEEVKQ SPSLSCLPPK PNRHHSVHSY PLLPAGLAWL
710 720 730 740 750
FATRSVFLYP ELLPHCSLDP ALHPSRSKHY YSKGEDGLLV LGLKHFAQTE
760 770 780 790 800
FPYQLISRYL IRPKRQEQLR MRVKDMVSPK YPHNIIKYYC QNHVVPPLPV
810 820 830 840 850
VCKPVVHGEE RPPVEREQEV MPNWLKKSLP LIQKSICQSD LTMTSTTKSA
860 870 880 890 900
SLPFPKETRY PQFLPKGLSL RLHPSQVASR PSQPKSRILR AFTNRTLAPL
910 920 930 940 950
AKAPSCPTGT GHLLTNISTP VLLLAQAPST PINGVFPLVH PSLTPAHGTV
960 970 980 990 1000
PLNASYPINF HYLSPELGAS NPAHLPANLP PSVVQKPQCD VPLLSTGTVK
1010 1020 1030 1040 1050
THGVQQQTSD KHKKRTMPRK LAPLRPAPQL PRLLPLSSGS IGNISNPGII
1060 1070 1080 1090 1100
IDQQISLNVP HNLQSDNVIV IKAHENVNTH RTVPSLSPDL VVQLVPQTQV
1110 1120 1130 1140 1150
AENTTSSLPR KTTPRSDVSQ TAKDIPSVQS SGENGQRTVF SPQTAAPAAV
1160 1170 1180 1190 1200
DSSQFVLVQT VSPTGPPQFL LLPQDSLVLN QPASLPSEGT LQNLSQQTSH
1210 1220 1230 1240 1250
LDISTTSTAL KNSEKTEVHL NNPTTSLPVS REEDGERQEV DEEMVGDRWE
1260 1270 1280 1290 1300
EEMASALFGS PLLALSESSC SPDSSPDASM DSGSDAMVRV EMEDGELPSV
1310 1320 1330 1340 1350
HSASATQETP DVHKHSSGDE KEQQSSGGEK QNSGNEEGRA EESESRKDEA
1360 1370 1380 1390 1400
QDEDKGGEKN EDGEGDGKRD EGGSGDKGRE EKDGDGEKDG DGERDEEEED
1410 1420 1430 1440 1450
FDDLTQDEDE EEVMSSASEE SVLSVPELQE TMEKLTWLAS ERRLCREGDS
1460 1470 1480 1490 1500
EEDNSPTSPT SPTSPNSQNS PASQNSQEEN SEDEDDGAMK GDELEAGEGE
1510 1520 1530 1540 1550
GEKLPEGDAP AGDDPPQISE KVGGRGRGRG RPPPRSLKRG RRQERGSKDA
1560 1570 1580 1590 1600
SKLLLLYDDH ILDNDPMRES KDMAYAQAYL NRVREALQDV PGKVEEFLGL
1610 1620 1630 1640 1650
LYEFDQAGES HSVIELFAQL KQLLKDWPEL LKDFAAFLLP EQALECGLFE
1660 1670 1680 1690 1700
EQQAFERSRR FLRQLEISFG ENPSHYQKIV RALQSGSPLS PAGIEELKTQ
1710 1720 1730 1740 1750
MATLLKGHTH LQGEFWMFFD EMRPPPARPG QFEEAVWPED VATGTDGEAG
1760 1770 1780 1790 1800
VSVTSRGGVW GGFEEVTLPD LDEDEESHKI RQISSRSKRR KELHTYKDCD
1810 1820 1830 1840 1850
WPEKDCSCSC HDSVHDAKHR RHKRKGCLRC QSNKAANGSK VLKGRDSAFS
1860 1870 1880 1890 1900
SADAQSERGG EEKEEERVLG EDGEAEKELK DETGSGANSP HHDGEGSVWE
1910 1920 1930 1940 1950
REERATSSIP EEQNTHNQDD EEKTEEKNHH ASPEKHSRDE EDSAESGQTE
1960 1970 1980 1990 2000
AAQQSSLSPA LDAPVCAKNI SLTPTGERVI LWTREADRVI LTTCQQQGAS
2010 2020 2030 2040 2050
QSTFQAVSEQ LGNKTASEVS RRFRDLMRLF HTSASQASSE DEAAEQQSAT

DEEQD
Length:2,055
Mass (Da):228,431
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE690F9EABCCD8789
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR848841 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001188464.1, NM_001201535.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000088023.4; ENSDARP00000082456.3; ENSDARG00000005867.13

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
555764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:555764

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848841 Genomic DNA No translation available.
RefSeqiNP_001188464.1, NM_001201535.1

3D structure databases

AlphaFoldDBiF1QI87
SMRiF1QI87
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109415

Proteomic databases

PaxDbiF1QI87

Genome annotation databases

EnsembliENSDART00000088023.4; ENSDARP00000082456.3; ENSDARG00000005867.13
GeneIDi555764
KEGGidre:555764

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
555764
ZFINiZDB-GENE-070117-2447, gon4lb

Phylogenomic databases

eggNOGiENOG502QT2W, Eukaryota
GeneTreeiENSGT00940000164105
HOGENOMiCLU_000833_0_0_1
InParanoidiF1QI87
OMAiHRNYKDC
OrthoDBi49443at2759
TreeFamiTF343327

Gene expression databases

BgeeiENSDARG00000005867, Expressed in blastula and 32 other tissues

Family and domain databases

Gene3Di1.20.1160.11, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR003822, PAH
IPR036600, PAH_sf
PfamiView protein in Pfam
PF02671, PAH, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47762, SSF47762, 2 hits
PROSITEiView protein in PROSITE
PS51477, PAH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QI87_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QI87
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 25, 2022
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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