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Entry version 60 (07 Apr 2021)
Sequence version 2 (20 Jan 2016)
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Protein
Submitted name:

Leucine-rich repeat (in FLII)-interacting protein 1a

Gene

lrrfip1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine-rich repeat (in FLII)-interacting protein 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lrrfip1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-99, lrrfip1a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QGV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000030012, Expressed in swim bladder and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1QGV4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000111467

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 106DisorderedSequence analysisAdd BLAST88
Regioni299 – 322DisorderedSequence analysisAdd BLAST24
Regioni336 – 424DisorderedSequence analysisAdd BLAST89
Regioni436 – 538DisorderedSequence analysisAdd BLAST103
Regioni965 – 996DisorderedSequence analysisAdd BLAST32
Regioni1008 – 1177DisorderedSequence analysisAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili128 – 162Sequence analysisAdd BLAST35
Coiled coili170 – 208Sequence analysisAdd BLAST39
Coiled coili212 – 235Sequence analysisAdd BLAST24
Coiled coili243 – 287Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 74PolyampholyteSequence analysisAdd BLAST56
Compositional biasi75 – 106PolarSequence analysisAdd BLAST32
Compositional biasi308 – 322PolarSequence analysisAdd BLAST15
Compositional biasi347 – 369PolarSequence analysisAdd BLAST23
Compositional biasi403 – 424PolyampholyteSequence analysisAdd BLAST22
Compositional biasi462 – 492PolyampholyteSequence analysisAdd BLAST31
Compositional biasi504 – 518BasicSequence analysisAdd BLAST15
Compositional biasi969 – 986AcidicSequence analysisAdd BLAST18
Compositional biasi1009 – 1023PolarSequence analysisAdd BLAST15
Compositional biasi1026 – 1058PolyampholyteSequence analysisAdd BLAST33
Compositional biasi1072 – 1086PolarSequence analysisAdd BLAST15
Compositional biasi1087 – 1101PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1108 – 1124PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1144 – 1177PolyampholyteSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRFIP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2010, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063564

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_273491_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QGV4

TreeFam database of animal gene trees

More...
TreeFami
TF314109

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019139, LRRFIP1/2

The PANTHER Classification System

More...
PANTHERi
PTHR19212, PTHR19212, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09738, LRRFIP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

F1QGV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AEARLAAKRA ARAEAREIRM KELERQQKEE DSERYTRVSR RHASVSDDEE
60 70 80 90 100
RMSVGSRSNV RADDRLERDY LEKGSSRAST ISGTTLTSLG GTSSRRGSGD
110 120 130 140 150
TSISADTEAS IREIKEIHEL KDQIHDVEAK HMQNLKELKD SLLEVEEKYR
160 170 180 190 200
KAMVSNAQLD NEKTNMMYEV DTLRDSLMEL EEMLFETRRE LEEKIKDLER
210 220 230 240 250
EKHAHSILQF QFSELKETLK QSEELLSDIR QLRLKQDGFV REISDLQETI
260 270 280 290 300
EWKNKKIGAL ERQKEFSDAI RNERDELRDE VVQLKDVLKK HGIVLGPDLV
310 320 330 340 350
TNGETGDEVG NADPNSQTAS AEIREGSSVL GIHQLKHKDQ EQKYLDDEVQ
360 370 380 390 400
GNQQSSNALF SSTNPPLEAN DNGVLGDSVV PGVGQHENRT EEPLSSVGDE
410 420 430 440 450
EVTATAPKEE VKSEEHELKD LKNNAVELKR KVCMGEHLET EQQESKCVNS
460 470 480 490 500
SQEIKEEAPL DSVSNTMHDE TDKPDEAVLD EQCKEEPVES SQMEEPPKTQ
510 520 530 540 550
VTSASNKKKK KKKKNKQKQK QSDKQESGTA MEVLNEDNSN QIVESVLEGT
560 570 580 590 600
NEEPLANAVS ETTMNADLPA SSCSDITTKG QDRIEVAATN TVVDDVHDGV
610 620 630 640 650
QLVTDEVDSA EISKSISNFD CSESSNDILS EGPSNNIISN TTDDPSNNII
660 670 680 690 700
CNTADDLSNN IISDTADDLS NNIISDTADD LSNNIISDTA DDLSNDIITN
710 720 730 740 750
TSVDLSSDII TNTPDDLSND SITNTADDPS NIIISDPATI IEERAEDSAN
760 770 780 790 800
SSLEPAITCS ELKSSEMEAS CHEPSVGPIT SENNKTLLVD AKEEKVDLEC
810 820 830 840 850
DEEPSPQNVD VDRICDPEDQ EASAQFDFHV MENVENKAEL MMQEQTVDPL
860 870 880 890 900
MDSQLQDSVQ SEVGKEKEQG ELDKENLEAH KEEVFAGSKV DYSPFIETQV
910 920 930 940 950
QVVQDDNLFT NEANQESVEP SDQNSMVEKV EEEISIQGLV TPDGQLPKDD
960 970 980 990 1000
NDLLIELDVV GLVHKQEDAD EEDEGESFDF DETDLEVSSD GPLKKSLDKL
1010 1020 1030 1040 1050
KEEVTLLKEN VQEASQENQS NVIDEDLTQE DEHLQLADQE SKPHEQKDDG
1060 1070 1080 1090 1100
HDTENMQSRD VEGCLTEKSL INCDVSPLSQ QHNTSANKED TFEEHQKALV
1110 1120 1130 1140 1150
DVPVSERVNL MSDKEKREVG QEISSSIPHK KQASVISGDP KLEKEITGNN
1160 1170
KEDESRESRK SAKGKGKGKG KEDCKMS
Length:1,177
Mass (Da):131,064
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD55ED8284238EB5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H1A5Y8H1A5Y8_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
1,168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QDT9F1QDT9_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
487Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G1K2J1G1K2J1_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QI65F1QI65_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IBX6A0A0R4IBX6_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IL11A0A0R4IL11_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
539Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0WEN2H0WEN2_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IUM2A0A0R4IUM2_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IXG0A0A0R4IXG0_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR545476 Genomic DNA No translation available.
CT867952 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000126198; ENSDARP00000111467; ENSDARG00000030012

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR545476 Genomic DNA No translation available.
CT867952 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111467

Proteomic databases

PaxDbiF1QGV4

Genome annotation databases

EnsembliENSDART00000126198; ENSDARP00000111467; ENSDARG00000030012

Organism-specific databases

ZFINiZDB-GENE-030131-99, lrrfip1a

Phylogenomic databases

eggNOGiKOG2010, Eukaryota
GeneTreeiENSGT00530000063564
HOGENOMiCLU_273491_0_0_1
InParanoidiF1QGV4
TreeFamiTF314109

Gene expression databases

BgeeiENSDARG00000030012, Expressed in swim bladder and 40 other tissues
ExpressionAtlasiF1QGV4, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019139, LRRFIP1/2
PANTHERiPTHR19212, PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738, LRRFIP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QGV4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QGV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: January 20, 2016
Last modified: April 7, 2021
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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