UniProtKB - F1QGH7 (CTNB1_DANRE)
Catenin beta-1
ctnnb1
Functioni
Key downstream component of the canonical Wnt signaling pathway (By similarity).
In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity).
In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity).
Plays a key role in dorsoventral patterning: in prospective ventral blastomeres, its down-regulation by axin1 and axin2 leads to inhibit the Wnt signaling pathway, while in prospective dorsal blastomeres, degradation of axin results in stabilization and nuclear translocation of ctnnb1 (PubMed:8562427, PubMed:30467143).
By similarity2 PublicationsGO - Molecular functioni
- alpha-catenin binding Source: GO_Central
- cadherin binding Source: ZFIN
- protein phosphatase binding Source: GO_Central
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- cell adhesion Source: ZFIN
- convergent extension Source: ZFIN
- determination of dorsal/ventral asymmetry Source: ZFIN
- dorsal/ventral pattern formation Source: ZFIN
- ectoderm development Source: ZFIN
- embryonic axis specification Source: ZFIN
- glomerular filtration Source: ZFIN
- liver development Source: ZFIN
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-DRE-195253, Degradation of beta-catenin by the destruction complex R-DRE-196299, Beta-catenin phosphorylation cascade R-DRE-201681, TCF dependent signaling in response to WNT R-DRE-201722, Formation of the beta-catenin:TCF transactivating complex R-DRE-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-DRE-351906, Apoptotic cleavage of cell adhesion proteins R-DRE-3769402, Deactivation of the beta-catenin transactivating complex R-DRE-4086398, Ca2+ pathway R-DRE-418990, Adherens junctions interactions R-DRE-5218920, VEGFR2 mediated vascular permeability R-DRE-525793, Myogenesis R-DRE-5626467, RHO GTPases activate IQGAPs R-DRE-8853884, Transcriptional Regulation by VENTX R-DRE-8951430, RUNX3 regulates WNT signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Catenin beta-1Alternative name(s): Beta-catenin |
Gene namesi | Name:ctnnb1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-980526-362, ctnnb1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane 2 Publications
Nucleus
- Nucleus 2 Publications
Note: Cytoplasmic when it is unstabilized (high level of phosphorylation). Translocates to the nucleus when it is stabilized (low level of phosphorylation). The majority of beta-catenin is localized to the cell membrane.By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- catenin complex Source: ZFIN
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: ZFIN
- cell cortex Source: UniProtKB
- intercalated disc Source: ZFIN
- membrane Source: ZFIN
- microvillus Source: ZFIN
- zonula adherens Source: ZFIN
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000446374 | 1 – 780 | Catenin beta-1Add BLAST | 780 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | F1QGH7 |
PRIDEi | F1QGH7 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSDARG00000014571, Expressed in gastrula and 44 other tissues |
Interactioni
GO - Molecular functioni
- alpha-catenin binding Source: GO_Central
- cadherin binding Source: ZFIN
- protein phosphatase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000032935 |
Structurei
Secondary structure
3D structure databases
SMRi | F1QGH7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q90424 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 140 – 179 | ARM 1Sequence analysisAdd BLAST | 40 | |
Repeati | 224 – 263 | ARM 2Sequence analysisAdd BLAST | 40 | |
Repeati | 266 – 305 | ARM 3Sequence analysisAdd BLAST | 40 | |
Repeati | 350 – 389 | ARM 4Sequence analysisAdd BLAST | 40 | |
Repeati | 399 – 430 | ARM 5PROSITE-ProRule annotationAdd BLAST | 32 | |
Repeati | 431 – 472 | ARM 6Sequence analysisAdd BLAST | 42 | |
Repeati | 478 – 518 | ARM 7Sequence analysisAdd BLAST | 41 | |
Repeati | 520 – 561 | ARM 8Sequence analysisAdd BLAST | 42 | |
Repeati | 583 – 622 | ARM 9Sequence analysisAdd BLAST | 40 | |
Repeati | 624 – 663 | ARM 10Sequence analysisAdd BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 56 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 735 – 770 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 48 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT00940000155471 |
HOGENOMi | CLU_008757_1_1_1 |
InParanoidi | F1QGH7 |
OrthoDBi | 321213at2759 |
PhylomeDBi | F1QGH7 |
TreeFami | TF317997 |
Family and domain databases
DisProti | DP02584 |
Gene3Di | 1.25.10.10, 1 hit |
IDEALi | IID50014 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MATQSDLMEL EMAMDPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG
60 70 80 90 100
NPEDDDVDNQ VLYEWEQGFN QSFNQEQVAD IDGQYAMTRA QRVRAAMFPE
110 120 130 140 150
TLDEGMQIPS TQFDSAHPTN VQRLAEPSQM LKHAVVNLIN YQDDAELATR
160 170 180 190 200
AIPELTKLLN DEDQVVVNKA AVMVHQLSKK EASRHAIMRS PQMVSAIVRT
210 220 230 240 250
MQNTNDVETA RCTSGTLHNL SHHREGLLAI FKSGGIPALV KMLGSPVDSV
260 270 280 290 300
LFYAITTLHN LLLHQEGAKM AVRLAGGLQK MVALLNKTNV KFLAITTDCL
310 320 330 340 350
QILAYGNQES KLIILASGGP QALVNIMRTY TYEKLLWTTS RVLKVLSVCS
360 370 380 390 400
SNKPAIVEAG GMQALGLHLT DPSQRLVQNC LWTLRNLSDA ATKQEGMEGL
410 420 430 440 450
LGTLVQLLGS DDINVVTCAA GILSNLTCNN YKNKMMVCQV GGIEALVRTV
460 470 480 490 500
LRAGDREDIT EPAICALRHL TSRHQDAEMA QNAVRLHYGL PVVVKLLHPP
510 520 530 540 550
SHWPLIKATV GLIRNLALCP ANHAPLREQG AIPRLVQLLV RAHQDTQRRT
560 570 580 590 600
SMGGTQQQFV EGVRMEEIVE GCTGALHILA RDIHNRIVIR GLNTIPLFVQ
610 620 630 640 650
LLYSPIENIQ RVAAGVLCEL AQDKEAAEAI EAEGATAPLT ELLHSRNEGV
660 670 680 690 700
ATYAAAVLFR MSEDKPQDYK KRLSVELTSS LFRTEPMTWN ETGDLGLDIG
710 720 730 740 750
AQGEPLGYRQ DDPSYRSFHS GGYGQDAMGM DPMMEHEMAG HHPGPDYPVD
760 770 780
GLPDLGHTQD LIDGLPPGDS NQLAWFDTDL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5H1ZRJ2 | A0A5H1ZRJ2_DANRE | Catenin beta-1 | ctnnb1 | 789 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | K → N in AAC59732 (PubMed:8562427).Curated | 1 | |
Sequence conflicti | 242 | M → V in AAH47815 (Ref. 3) Curated | 1 | |
Sequence conflicti | 253 | Y → H in AAC59732 (PubMed:8562427).Curated | 1 | |
Sequence conflicti | 446 | L → P in AAH47815 (Ref. 3) Curated | 1 | |
Sequence conflicti | 571 | G → A in AAC59732 (PubMed:8562427).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U41081 mRNA Translation: AAC59732.1 CABZ01038334 Genomic DNA No translation available. BC047815 mRNA Translation: AAH47815.1 |
RefSeqi | NP_571134.2, NM_131059.2 |
Genome annotation databases
Ensembli | ENSDART00000038495; ENSDARP00000032935; ENSDARG00000014571 |
GeneIDi | 30265 |
KEGGi | dre:30265 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U41081 mRNA Translation: AAC59732.1 CABZ01038334 Genomic DNA No translation available. BC047815 mRNA Translation: AAH47815.1 |
RefSeqi | NP_571134.2, NM_131059.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Z6G | X-ray | 3.40 | A | 1-780 | [»] | |
SMRi | F1QGH7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000032935 |
Proteomic databases
PaxDbi | F1QGH7 |
PRIDEi | F1QGH7 |
Genome annotation databases
Ensembli | ENSDART00000038495; ENSDARP00000032935; ENSDARG00000014571 |
GeneIDi | 30265 |
KEGGi | dre:30265 |
Organism-specific databases
CTDi | 1499 |
ZFINi | ZDB-GENE-980526-362, ctnnb1 |
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT00940000155471 |
HOGENOMi | CLU_008757_1_1_1 |
InParanoidi | F1QGH7 |
OrthoDBi | 321213at2759 |
PhylomeDBi | F1QGH7 |
TreeFami | TF317997 |
Enzyme and pathway databases
Reactomei | R-DRE-195253, Degradation of beta-catenin by the destruction complex R-DRE-196299, Beta-catenin phosphorylation cascade R-DRE-201681, TCF dependent signaling in response to WNT R-DRE-201722, Formation of the beta-catenin:TCF transactivating complex R-DRE-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-DRE-351906, Apoptotic cleavage of cell adhesion proteins R-DRE-3769402, Deactivation of the beta-catenin transactivating complex R-DRE-4086398, Ca2+ pathway R-DRE-418990, Adherens junctions interactions R-DRE-5218920, VEGFR2 mediated vascular permeability R-DRE-525793, Myogenesis R-DRE-5626467, RHO GTPases activate IQGAPs R-DRE-8853884, Transcriptional Regulation by VENTX R-DRE-8951430, RUNX3 regulates WNT signaling |
Miscellaneous databases
EvolutionaryTracei | Q90424 |
PROi | PR:F1QGH7 |
Gene expression databases
Bgeei | ENSDARG00000014571, Expressed in gastrula and 44 other tissues |
Family and domain databases
DisProti | DP02584 |
Gene3Di | 1.25.10.10, 1 hit |
IDEALi | IID50014 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CTNB1_DANRE | |
Accessioni | F1QGH7Primary (citable) accession number: F1QGH7 Secondary accession number(s): A0A0N4SUA5, Q7ZU14, Q90424 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 13, 2019 |
Last sequence update: | May 3, 2011 | |
Last modified: | February 23, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families