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Entry version 62 (16 Jan 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Bromodomain-containing 1a

Gene

brd1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-6804758 Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Bromodomain-containing 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:brd1aImported
Synonyms:brd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041008-168 brd1a

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000013596 Expressed in 18 organ(s), highest expression level in mature ovarian follicle

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000116486

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 246PHD-typeInterPro annotationAdd BLAST51
Domaini250 – 372PHD-typeInterPro annotationAdd BLAST123
Domaini558 – 628BromoInterPro annotationAdd BLAST71
Domaini1013 – 1096PWWPInterPro annotationAdd BLAST84

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili487 – 514Sequence analysisAdd BLAST28
Coiled coili517 – 537Sequence analysisAdd BLAST21

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157236

Identification of Orthologs from Complete Genome Data

More...
OMAi
NESHSTC

Database of Orthologous Groups

More...
OrthoDBi
566217at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05839 BR140_related, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1QFR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRKSQPLNI FTPHREPLTY AQAQRMVDLE VDGQLHRISI FDKLEIITDE
60 70 80 90 100
DPLAQEIIKC ISSKENAEKH LQISEYSAQI KNNNQKKNTS DSSIQGSILP
110 120 130 140 150
EPKFHTVDYN LPVIPSRPST YYKYKQKTVE ELDQEVEYDM DEEDFAWLDL
160 170 180 190 200
VNEKRKDEGL NLVSFDDFEF LLDRFEKESF LESQGQHTLQ SIDDEDAVCC
210 220 230 240 250
ICMDGDCMDS NVILFCDMCN LAVHQDCYGV PYIPEGQWLC RHCLHSPTQP
260 270 280 290 300
ANCILCPNKG GAVKQTEDDR WGHVVCALWV PEVGFSNTVF IEPIDGVSNI
310 320 330 340 350
PPARWKLTCY LCKEKGVGAC IQCHKANCYT AFHVSCAQKS GLFMKMEPIK
360 370 380 390 400
VLTDSGIPTF SVKKTAYCGA HTPNGSVKRP LAIYKDNETN YGLCQLVDRK
410 420 430 440 450
SSRIGFNKQK RLKKNEEAIV TTIPPLSVPS FSSERLSPIL NQVSLQKKTA
460 470 480 490 500
FGELVLSYWT LKRQSRNGVP LNRRLQTRLH PPKNSQRKQT EEETQALKEQ
510 520 530 540 550
LKEWHQLRHD LERARILLEL IRKREKLKRE EVLLQQTLME FQLTPFTVIL
560 570 580 590 600
RAVLDQLQEK DQAHIFAEPV NIKEVPDYMD HVLHPMDFST MSKRIEAQGY
610 620 630 640 650
KYLDEFEADF NLITDNCMKY NGKDTFFYRA AVKLRDQGGA ILRKTRRDVQ
660 670 680 690 700
RIGLDLETGL HLLEPPKIEP SVPFSWEDVD RLLVPANREH MSFEEQLREL
710 720 730 740 750
LEKLDMTTAM KSSPSRSRRL KLLKKNISDV RLELSLRKAL TAVKLKNAAE
760 770 780 790 800
EEVGHIHQKG DKSVPPKLEP SVSVLPLINA ESHSEPPTLK PIEPNPDKHS
810 820 830 840 850
HQKDGISQSL NGDSHLLLED SDINVVATST LAEPSSPVNR RTSVLFRKSK
860 870 880 890 900
SSTSPLRTLK DDETLKGSSQ IGTKTFLSVV IPRLETLLHT RKRPRSASGD
910 920 930 940 950
SCKDELPVKR LDTELSNSFG LNSERELSSS SQPRQRCTSE SSMSSSNSSI
960 970 980 990 1000
ALNLTKCGKG KPALIRRNTV EDKSEIIACI ESRNFAKAAR IAAEVNSSSI
1010 1020 1030 1040 1050
WMPSNAATVL LEPLKVVWAK CSGYPSYPAL IIDPQMPRVG CQHNGVSIPM
1060 1070 1080 1090 1100
PPLNVLQIGE QMQYKSEEKL YLVLFFDNKR TWQWLHKSKM VPLGVDKTID
1110 1120 1130 1140
KIKMMEGRTS AIRKAVRTAF NRAMNHLNHV QDEPVNDFSD VD
Length:1,142
Mass (Da):129,816
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAE864873432BE20
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR751234 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_698063.5, XM_692971.7

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.135887
Dr.91233

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000013083; ENSDARP00000018937; ENSDARG00000013596
ENSDART00000145083; ENSDARP00000116486; ENSDARG00000013596
ENSDART00000192157; ENSDARP00000152825; ENSDARG00000116694

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
569574

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR751234 Genomic DNA No translation available.
RefSeqiXP_698063.5, XM_692971.7
UniGeneiDr.135887
Dr.91233

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116486

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000013083; ENSDARP00000018937; ENSDARG00000013596
ENSDART00000145083; ENSDARP00000116486; ENSDARG00000013596
ENSDART00000192157; ENSDARP00000152825; ENSDARG00000116694
GeneIDi569574

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
569574
ZFINiZDB-GENE-041008-168 brd1a

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA
GeneTreeiENSGT00940000157236
OMAiNESHSTC
OrthoDBi566217at2759
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-DRE-6804758 Regulation of TP53 Activity through Acetylation

Gene expression databases

BgeeiENSDARG00000013596 Expressed in 18 organ(s), highest expression level in mature ovarian follicle

Family and domain databases

CDDicd05839 BR140_related, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QFR1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QFR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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