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Entry version 73 (19 Jan 2022)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

RNA-binding motif protein 19

Gene

rbm19

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: ZFIN

GO - Biological processi

  • digestive tract morphogenesis Source: ZFIN
  • mRNA splicing, via spliceosome Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RNA-binding motif protein 19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rbm19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-031125-3, rbm19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QF98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000042590, Expressed in gastrula and 30 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000062458

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 79RRMInterPro annotationAdd BLAST78
Domaini290 – 365RRMInterPro annotationAdd BLAST76
Domaini399 – 477RRMInterPro annotationAdd BLAST79
Domaini585 – 657RRMInterPro annotationAdd BLAST73
Domaini702 – 783RRMInterPro annotationAdd BLAST82
Domaini805 – 884RRMInterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni83 – 121DisorderedSequence analysisAdd BLAST39
Regioni153 – 289DisorderedSequence analysisAdd BLAST137
Regioni478 – 508DisorderedSequence analysisAdd BLAST31
Regioni664 – 699DisorderedSequence analysisAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili373 – 393Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi85 – 121Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi159 – 180Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi181 – 204Acidic residuesSequence analysisAdd BLAST24
Compositional biasi205 – 239Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi240 – 256Acidic residuesSequence analysisAdd BLAST17
Compositional biasi268 – 286Polar residuesSequence analysisAdd BLAST19
Compositional biasi684 – 698Acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0110, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00840000129953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008479_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QF98

Identification of Orthologs from Complete Genome Data

More...
OMAi
TALIEYC

Database of Orthologous Groups

More...
OrthoDBi
1428854at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105725

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12564, RRM1_RBM19, 1 hit
cd12502, RRM2_RMB19, 1 hit
cd12567, RRM3_RBM19, 1 hit
cd12569, RRM4_RBM19, 1 hit
cd12318, RRM5_RBM19_like, 1 hit
cd12571, RRM6_RBM19, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034419, RBM19_RRM3
IPR034420, RBM19_RRM4
IPR034423, RBM19_RRM5
IPR034421, RBM19_RRM6
IPR034418, RMB19_RRM1
IPR034417, RMB19_RRM2
IPR000504, RRM_dom
IPR003954, RRM_dom_euk

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 6 hits
SM00361, RRM_1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1QF98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLIVKNLP NGMKEDRFRK MFADFGTLTD CALKFTKDGK FRKFGFVGFK
60 70 80 90 100
TEEDAQKALK HFNKSFVDTS RVTVELCTDF GDPNKARPWS KHTRQPSSKK
110 120 130 140 150
DTEEKKTHEQ GEKEKKKPKK ILNVLGDLEK DESFQEFLAV HQKRGQVPTW
160 170 180 190 200
ANDTVEATAV RPEMEKKKEK KQKAAVEDDY LNFDSDESEE SSDDGEDAAD
210 220 230 240 250
EEDKQDNEKE ALKTGLSDMD YLRSKMVEKS DMLDEKDDDS SASAADENEE
260 270 280 290 300
DEGKEEEESI VQHADSAYES GEKTSSQKST RPAIEPTTEF TVKLRGAPFN
310 320 330 340 350
VKEQQVKEFM MPLKPVAIRF AKNSDGRNSG YVYVDLRSEA EVERALRLDK
360 370 380 390 400
DYMGGRYIEV FRANNFKNDR RSAKRSEMEK NFVRELKDDE EEEDVAESGR
410 420 430 440 450
LFIRNMPYTC TEEDLKEVFS KHGPLSEVLF PIDSLTKKPK GFAFVTYMIP
460 470 480 490 500
ENAVSALAQL DGHTFQGRVL HVMASRLKKE KADQGPDAPG SSSYKRKKDA
510 520 530 540 550
KDKAASGSSH NWNTLFLGTS AVADAIAEKY NTTKSQVLDH ESDGSLAVRM
560 570 580 590 600
ALGETQIVQE TRQFLLDNGV SLDSFSQASG ERSKCVILVK NLPSGVQVAD
610 620 630 640 650
LEALFSPHGS LGRVLLPPSG LTAIVEFLEP TEAKRAFMKL AYTKFQHVPL
660 670 680 690 700
YLEWAPVAVF TTPSAPRPEP QTKEKSAVKN DSVQNEEEEE EEEEDDQILP
710 720 730 740 750
GSTLFIKNLN FITSEETLQK TFSKCGVVKS CTISKKRDKA GKLLSMGYGF
760 770 780 790 800
VQYKTPEAAQ KAMRQLQHCT VDEHQLEVKI SEREVKSGVA QAKRKKQTAR
810 820 830 840 850
KQTTSKILVR NIPFQATVKE LRELFCTFGE LKTVRLPKKG IGGSHRGFGF
860 870 880 890 900
IDFLTKQDAK KAFSALCHST HLYGRRLVLE WADAEETVDD LRRKTAQHFH
910 920
DAPKKKRKAE VLEGILEQME VGDGDGE
Length:927
Mass (Da):104,566
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E02C5278797D91F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QGL1A0A2R8QGL1_DANRE
RNA-binding motif protein 19
rbm19
927Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX323075 Genomic DNA No translation available.
CT033836 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_944597.2, NM_198915.2
XP_017211937.1, XM_017356448.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000062459; ENSDARP00000062458; ENSDARG00000042590
ENSDART00000180563; ENSDARP00000157568; ENSDARG00000042590

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:387255

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323075 Genomic DNA No translation available.
CT033836 Genomic DNA No translation available.
RefSeqiNP_944597.2, NM_198915.2
XP_017211937.1, XM_017356448.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062458

Proteomic databases

PaxDbiF1QF98

Genome annotation databases

EnsembliENSDART00000062459; ENSDARP00000062458; ENSDARG00000042590
ENSDART00000180563; ENSDARP00000157568; ENSDARG00000042590
GeneIDi387255
KEGGidre:387255

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9904
ZFINiZDB-GENE-031125-3, rbm19

Phylogenomic databases

eggNOGiKOG0110, Eukaryota
GeneTreeiENSGT00840000129953
HOGENOMiCLU_008479_1_0_1
InParanoidiF1QF98
OMAiTALIEYC
OrthoDBi1428854at2759
TreeFamiTF105725

Gene expression databases

BgeeiENSDARG00000042590, Expressed in gastrula and 30 other tissues

Family and domain databases

CDDicd12564, RRM1_RBM19, 1 hit
cd12502, RRM2_RMB19, 1 hit
cd12567, RRM3_RBM19, 1 hit
cd12569, RRM4_RBM19, 1 hit
cd12318, RRM5_RBM19_like, 1 hit
cd12571, RRM6_RBM19, 1 hit
Gene3Di3.30.70.330, 6 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034419, RBM19_RRM3
IPR034420, RBM19_RRM4
IPR034423, RBM19_RRM5
IPR034421, RBM19_RRM6
IPR034418, RMB19_RRM1
IPR034417, RMB19_RRM2
IPR000504, RRM_dom
IPR003954, RRM_dom_euk
PfamiView protein in Pfam
PF00076, RRM_1, 6 hits
SMARTiView protein in SMART
SM00360, RRM, 6 hits
SM00361, RRM_1, 2 hits
SUPFAMiSSF54928, SSF54928, 5 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QF98_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QF98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 19, 2022
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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