UniProtKB - F1QDD0 (F1QDD0_DANRE)
Protein
Submitted name:
Growth differentiation factor 10b
Gene
gdf10b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Growth differentiation factor 10bImported |
Gene namesi | Name:gdf10bImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-120316-1, gdf10b |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5003272526 | 25 – 422 | Sequence analysisAdd BLAST | 398 |
Proteomic databases
PaxDbi | F1QDD0 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000073891, Expressed in head and 15 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000098571 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 310 – 422 | TGF_BETA_2InterPro annotationAdd BLAST | 113 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157214 |
HOGENOMi | CLU_020515_10_0_1 |
InParanoidi | F1QDD0 |
OMAi | LWQNTYF |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1QDD0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVCAVARV LLCLNVVKVY LVSSELNGDI PAEEPTIHSP ARDMMTVHMY
60 70 80 90 100
RVYDKYSKKQ QQHQQQLNVN TIRSFRGVPE LSHHKVVFHF NLTSVPDSEM
110 120 130 140 150
ILTSNLHYPD QQSRPRSWAC QRSRRSSCRL QYLQTTTPRL IIKASSANAA
160 170 180 190 200
VPTQLSNITL PPNRKTLWQT ADVSSAMKQA HANAELLISI EFDFGHHKRQ
210 220 230 240 250
EHLPPHNMPF ILVYADDIDI TEPNSVAGSL QRYSPSPVDS KASPLTSRIR
260 270 280 290 300
REVGHLKENQ VPGVRYIDLK SGGLWDGAFF AKQNKPLTDI EGSRGSQELT
310 320 330 340 350
FDEKTMKKAR RKQWSEPRVC TRRYLRVDFA DIGWSEWILA PKAFDAYYCA
360 370 380 390 400
GTCAFPIPKV VHPSNHATIQ SIVRAVGIVP GVPDPCCVPD KMSSLAVLFL
410 420
DSSRNMLLKI YPSMSVETCA CR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR450691 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000114209; ENSDARP00000098571; ENSDARG00000073891 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR450691 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000098571 |
Proteomic databases
PaxDbi | F1QDD0 |
Genome annotation databases
Ensembli | ENSDART00000114209; ENSDARP00000098571; ENSDARG00000073891 |
Organism-specific databases
ZFINi | ZDB-GENE-120316-1, gdf10b |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157214 |
HOGENOMi | CLU_020515_10_0_1 |
InParanoidi | F1QDD0 |
OMAi | LWQNTYF |
TreeFami | TF316134 |
Gene expression databases
Bgeei | ENSDARG00000073891, Expressed in head and 15 other tissues |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1QDD0_DANRE | |
Accessioni | F1QDD0Primary (citable) accession number: F1QDD0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | December 2, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |