UniProtKB - F1QDC4 (F1QDC4_DANRE)
Protein
Submitted name:
ADAM metallopeptidase domain 28
Gene
adam28
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: ADAM metallopeptidase domain 28Imported |
Gene namesi | Name:adam28Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060929-532, adam28 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 666 – 688 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5006465950 | 23 – 765 | Sequence analysisAdd BLAST | 743 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 461 ↔ 481 | PROSITE-ProRule annotation | ||
Disulfide bondi | 624 ↔ 634 | PROSITE-ProRule annotation | ||
Disulfide bondi | 642 ↔ 651 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000035514, Expressed in zone of skin and 22 other tissues |
ExpressionAtlasi | F1QDC4, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 395 | Peptidase M12BInterPro annotationAdd BLAST | 196 | |
Domaini | 403 – 489 | DisintegrinInterPro annotationAdd BLAST | 87 | |
Domaini | 620 – 652 | EGF-likeInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 716 – 765 | DisorderedSequence analysisAdd BLAST | 50 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 206 – 226 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 729 – 745 | Pro-richSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156716 |
HOGENOMi | CLU_012714_7_1_1 |
OMAi | ICVMDRA |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F1QDC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQRHLMLWI FTLCVSLDPS VGHIHELHGK VYEIVRPIRL HDLQKRDLQS
60 70 80 90 100
RPDRVKYAMT LGGRDIEMHL QKNTGMLTKD YSETYYTDDG MLVTTTPADL
110 120 130 140 150
DLCYYHGKIL NDSASLVSMS TCDGLRGYFQ TAEQRFLIEP LSEDSDGDHA
160 170 180 190 200
VFKYEDVNEA TPRVCGVTNT TWDESGDGVP PRILKTRSRS SGPTLFQRQK
210 220 230 240 250
YNEFFLVADN REYKKLNSDL EKLRKRIFEI INFINNVYKE INTFVALTGF
260 270 280 290 300
EVWTDNDKIT VSAASGATLD SFTKWRNSDL IKRQRHDNAH LLTAIDLDGA
310 320 330 340 350
TVGLAYIGTL CGGLSTGIVQ DHNSMATAVG ATIAHEMGHN LGMNHDSSSC
360 370 380 390 400
VCSDSSCIMT AALSYFIPQH FSSCSTGAFV DYLNNKVPEC LLNKPQPRDL
410 420 430 440 450
LQPAVCGNGF VEIGEECDCG TVQECKNPCC NATTCKLTVG SQCAAGECCD
460 470 480 490 500
NCKIMSASHV CRPKADDCDL PESCTGKSAE CPEDVFTVNG VPCKNGKGYC
510 520 530 540 550
YNGQCPMKEE QCIKMWGSTS VVARDSCYSQ NTRAEYYAYC KRNGDKYIGC
560 570 580 590 600
QKQDIMCGKL FCESGNDNPN YGRLVTFSNC KATFYGSPDE DYGQVDTGTK
610 620 630 640 650
CGEGLVCNQN ECVGLETAYK ATNCSNKCKG HGVCDHRLQC KCEPGWLPPD
660 670 680 690 700
CDKPAESEGL SKGVTIAISV IVTIVIVILL IGLTVFLCKR RTSTPHAYRG
710 720 730 740 750
QPRQQKVHVV DIPDLSQQRS ATPNQKPTPV IKPSAPPPPP PYSVHAPHNE
760
FMAARQALRP PPPRV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA3KQJ0 | A3KQJ0_DANRE | ADAM metallopeptidase domain 28 | adam28 | 762 | Annotation score: | ||
A0A2R8QJX9 | A0A2R8QJX9_DANRE | ADAM metallopeptidase domain 28 | adam28 | 293 | Annotation score: | ||
A0A2R8QF72 | A0A2R8QF72_DANRE | ADAM metallopeptidase domain 28 | adam28 | 293 | Annotation score: | ||
A0A2R8QP33 | A0A2R8QP33_DANRE | ADAM metallopeptidase domain 28 | adam28 | 286 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX666060 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000130936; ENSDARP00000109705; ENSDARG00000035514 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX666060 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000130936; ENSDARP00000109705; ENSDARG00000035514 |
Organism-specific databases
ZFINi | ZDB-GENE-060929-532, adam28 |
Phylogenomic databases
GeneTreei | ENSGT00940000156716 |
HOGENOMi | CLU_012714_7_1_1 |
OMAi | ICVMDRA |
Gene expression databases
Bgeei | ENSDARG00000035514, Expressed in zone of skin and 22 other tissues |
ExpressionAtlasi | F1QDC4, baseline |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1QDC4_DANRE | |
Accessioni | F1QDC4Primary (citable) accession number: F1QDC4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | January 20, 2016 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |