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Entry version 59 (03 Jul 2019)
Sequence version 2 (20 Jun 2018)
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Protein
Submitted name:

Roundabout, axon guidance receptor, homolog 2 (Drosophila)

Gene

robo2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Roundabout, axon guidance receptor, homolog 2 (Drosophila)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:robo2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-001019-1 robo2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei741 – 763HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1QBD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000014891 Expressed in 19 organ(s), highest expression level in head

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000109639

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 93Ig-likeInterPro annotationAdd BLAST93
Domaini98 – 185Ig-likeInterPro annotationAdd BLAST88
Domaini194 – 289Ig-likeInterPro annotationAdd BLAST96
Domaini298 – 378Ig-likeInterPro annotationAdd BLAST81
Domaini405 – 499Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini518 – 616Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini620 – 717Fibronectin type-IIIInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni946 – 1002DisorderedSequence analysisAdd BLAST57
Regioni1056 – 1088DisorderedSequence analysisAdd BLAST33
Regioni1116 – 1387DisorderedSequence analysisAdd BLAST272

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi947 – 973PolarSequence analysisAdd BLAST27
Compositional biasi1072 – 1088PolarSequence analysisAdd BLAST17
Compositional biasi1143 – 1159AcidicSequence analysisAdd BLAST17
Compositional biasi1168 – 1182PolarSequence analysisAdd BLAST15
Compositional biasi1283 – 1318PolyampholyteSequence analysisAdd BLAST36
Compositional biasi1335 – 1354PolarSequence analysisAdd BLAST20
Compositional biasi1364 – 1387PolarSequence analysisAdd BLAST24

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4222 Eukaryota
ENOG410XPQS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156324

TreeFam database of animal gene trees

More...
TreeFami
TF351053

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00406 IGv, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1QBD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VSVLRDDFRQ NPTDVVVAAG EPAILECVPP RGHPEPTIYW KKDKVRIDEK
60 70 80 90 100
DDRIKIRGGK LMISNTRKSD AGMYICVGTN MVGERDSETA QVTVFERPTF
110 120 130 140 150
LRRPINQVVL EEEAVEFRCQ VQGDPQPSIR WKKDDVEIPR GRYDMKFDKD
160 170 180 190 200
DFTLRIKKAT ASDEGTFTCV AENRVGKMEA SATLTVRVLG SAAPQFVIRP
210 220 230 240 250
RDQIVAQGRT ASFPCETKGN PQPAVFWQKE GSQNLLFPNQ PQQPNSRFSV
260 270 280 290 300
SPSGDLTITT VQRADAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII
310 320 330 340 350
RQGPANQTLG VDSVALLRCH ASGEPVPTIS WLKDGVSLLG KDPRMSLQDL
360 370 380 390 400
GSLQIKGLRL SDSGIYTCVA ASSSGETSWS AFLEVKEAGS LVVVKDRDEN
410 420 430 440 450
ELPGPPSKPQ VTDVTKNSVS LSWQPGLPGA SAISTYVIEA FSQSVSNSWQ
460 470 480 490 500
TVADHAKTTQ YTIKGLRPNT IYLFMVRAVN VQGLSDPSPM SEPVRTQDIS
510 520 530 540 550
PPAQGVDHRH VQKELGEVIV RLHNPVVLSP TTIQVTWTVD RQSQFIQGYR
560 570 580 590 600
VLYRQMSGLS SPGAWQTQDV KVPSERSMVL SALKKGIVYE IKVRPYFNEF
610 620 630 640 650
QGMDSESRTA RTTEEAPSAP PQQVTVLTVG NQNSTSISIS WDPPPAEHQN
660 670 680 690 700
GIIQEYKIWC LGNETRFHVN KTVDAAIRSV VVGGLQAGVQ YRVEVAASTS
710 720 730 740 750
AGVGVKSEPQ TIIIGKDFRD VMISRNNSIT EQITDVVKQP AFIAGIGGAC
760 770 780 790 800
WVILMGFSIW LYWRRKKRKG LSNYAVQSFT FTPAVTFQRV DGGLMSNGSR
810 820 830 840 850
PGLLNASDSG YPWLADSWPP SLPVNSGSGG PNDLSFGRGD VMPSAQADKT
860 870 880 890 900
GTMLSDGAIY SSIDFTTKGG FGSPSPASQA TPYATTQILH SNSIHELAVD
910 920 930 940 950
LPEAQWKTSL QAKQEMASLG YSLPDKNSCN NTLLFIPDYR LADGLSNRMP
960 970 980 990 1000
HNQSQDFSTT SSHNSSDRSN SLSGGKGGKK KKTKANVKPT KMNGSNWANV
1010 1020 1030 1040 1050
PLPPPPIHPL PGTEMDHYAS EHHDGGGYDS DGWGPPLPVQ TYLHQGLEDE
1060 1070 1080 1090 1100
LEEEEERVPT PPIRGVASSP AAVSFGKQST ATLSPSPREE MQPMLQAHLD
1110 1120 1130 1140 1150
ELTRAYQLDM AKQTWHMQGG PYPPQAPAPP VGYVSSTLVS DIETDLPDED
1160 1170 1180 1190 1200
DDDEEDEGYE MSPPIRGTEH TPGSSMDNLD SSVTDKGLPH RPRPASPFST
1210 1220 1230 1240 1250
DGSTVGTHSL GHQRAARPTR KHKGPGTVPN RRDASADDLP PPPEPPPCQT
1260 1270 1280 1290 1300
ARIPGSRNVP HPCDRKASSL ERQPMMGLEE MRSSLDRQAR TSLDRHQQVQ
1310 1320 1330 1340 1350
DRLGSIERGD ESRRGQKNGP FSEEALLPYN KPSFPSPGGH SSSGTASSKG
1360 1370 1380
STGPRKGEGT RGQHQRSTTE QGESSYMGTN AQFSGEL
Length:1,387
Mass (Da):151,059
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF53E7078C8481FB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1LY64Q1LY64_DANRE
Roundabout, axon guidance receptor,...
robo2
128Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q4U8A0A2R8Q4U8_DANRE
Roundabout, axon guidance receptor,...
robo2
136Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABZ01010266 Genomic DNA No translation available.
CABZ01010267 Genomic DNA No translation available.
CABZ01010268 Genomic DNA No translation available.
CU655828 Genomic DNA No translation available.
CU658505 Genomic DNA No translation available.
FO818666 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000014877; ENSDARP00000012875; ENSDARG00000014891
ENSDART00000129511; ENSDARP00000109639; ENSDARG00000014891

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01010266 Genomic DNA No translation available.
CABZ01010267 Genomic DNA No translation available.
CABZ01010268 Genomic DNA No translation available.
CU655828 Genomic DNA No translation available.
CU658505 Genomic DNA No translation available.
FO818666 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109639

Proteomic databases

PaxDbiF1QBD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000014877; ENSDARP00000012875; ENSDARG00000014891
ENSDART00000129511; ENSDARP00000109639; ENSDARG00000014891

Organism-specific databases

ZFINiZDB-GENE-001019-1 robo2

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00940000156324
TreeFamiTF351053

Gene expression databases

BgeeiENSDARG00000014891 Expressed in 19 organ(s), highest expression level in head

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QBD4_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QBD4
Secondary accession number(s): F1QEH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 20, 2018
Last modified: July 3, 2019
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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