GLI family zinc finger 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• abducens nerve development Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• abducens nucleus development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• adenohypophysis development Source: ZFINInferred from mutant phenotypeⁱ
  • "Multiple roles for Hedgehog signaling in zebrafish pituitary development."
    Sbrogna J.L., Barresi M.J., Karlstrom R.O.
    Dev Biol 254:19-35(2003) [PubMed] [Europe PMC] [Abstract]
  • "Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development."
    Karlstrom R.O., Tyurina O.V., Kawakami A., Nishioka N., Talbot W.S., Sasaki H., Schier A.F.
    Development 130:1549-1564(2003) [PubMed] [Europe PMC] [Abstract]
• adenohypophysis morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary."
    Devine C.A., Sbrogna J.L., Guner B., Osgood M., Shen M.C., Karlstrom R.O.
    Dev Biol 326:143-154(2009) [PubMed] [Europe PMC] [Abstract]
• brain development Source: ZFINInferred from mutant phenotypeⁱ
  • "Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development."
    Karlstrom R.O., Tyurina O.V., Kawakami A., Nishioka N., Talbot W.S., Sasaki H., Schier A.F.
    Development 130:1549-1564(2003) [PubMed] [Europe PMC] [Abstract]
• cranial nerve development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• facial nerve development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• facial nucleus development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• floor plate formation Source: ZFINInferred from mutant phenotypeⁱ
  • "Discontinuous organization and specification of the lateral floor plate in zebrafish."
    Schafer M., Kinzel D., Winkler C.
    Dev Biol 301:117-129(2007) [PubMed] [Europe PMC] [Abstract]
• generation of neurons Source: ZFINInferred from mutant phenotypeⁱ
  • "Gli function is essential for motor neuron induction in zebrafish."
    Vanderlaan G., Tyurina O.V., Karlstrom R.O., Chandrasekhar A.
    Dev Biol 282:550-570(2005) [PubMed] [Europe PMC] [Abstract]
• glossopharyngeal nerve development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• muscle cell fate specification Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish."
    Wang X., Zhao Z., Muller J., Iyu A., Khng A.J., Guccione E., Ruan Y., Ingham P.W.
    Biol Open 2:1203-1213(2013) [PubMed] [Europe PMC] [Abstract]
• neural tube patterning Source: ZFINInferred from mutant phenotypeⁱ
  • "Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish."
    Wang X., Zhao Z., Muller J., Iyu A., Khng A.J., Guccione E., Ruan Y., Ingham P.W.
    Biol Open 2:1203-1213(2013) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons."
    Ungos J.M., Karlstrom R.O., Raible D.W.
    Development 130:5351-5362(2003) [PubMed] [Europe PMC] [Abstract]
• odontogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas."
    Wiweger M.I., Zhao Z., van Merkesteyn R.J., Roehl H.H., Hogendoorn P.C.
    PLoS One 7:e29734-e29734(2012) [PubMed] [Europe PMC] [Abstract]
• pituitary gland development Source: ZFINInferred from mutant phenotypeⁱ
  • "Gonadotropin-releasing hormone (GnRH) cells arise from cranial neural crest and adenohypophyseal regions of the neural plate in the zebrafish, Danio rerio."
    Whitlock K.E., Wolf C.D., Boyce M.L.
    Dev Biol 257:140-152(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smoothened signaling pathway Source: ZFINInferred from genetic interactionⁱ
  • "Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia."
    Huang P., Schier A.F.
    Development 136:3089-3098(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of neurogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity."
    Ninkovic J., Stigloher C., Lillesaar C., Bally-Cuif L.
    Development 135:3137-3148(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development."
    Karlstrom R.O., Tyurina O.V., Kawakami A., Nishioka N., Talbot W.S., Sasaki H., Schier A.F.
    Development 130:1549-1564(2003) [PubMed] [Europe PMC] [Abstract]
• retinal ganglion cell axon guidance Source: ZFINInferred from mutant phenotypeⁱ
  • "Zebrafish mutations affecting retinotectal axon pathfinding."
    Karlstrom R.O., Trowe T., Klostermann S., Baier H., Brand M., Crawford A.D., Grunewald B., Haffter P., Hoffmann H., Meyer S.U., Muller B.K., Richter S., van Eeden F.J., Nusslein-Volhard C., Bonhoeffer F.
    Development 123:427-438(1996) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway Source: ZFINInferred from direct assayⁱ
  • "Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development."
    Karlstrom R.O., Tyurina O.V., Kawakami A., Nishioka N., Talbot W.S., Sasaki H., Schier A.F.
    Development 130:1549-1564(2003) [PubMed] [Europe PMC] [Abstract]
• trigeminal motor nucleus development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• trigeminal nerve development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• vagus nerve development Source: ZFINInferred from mutant phenotypeⁱ
  • "The zebrafish detour gene is essential for cranial but not spinal motor neuron induction."
    Chandrasekhar A., Schauerte H.E., Haffter P., Kuwada J.Y.
    Development 126:2727-2737(1999) [PubMed] [Europe PMC] [Abstract]
• ventral spinal cord interneuron specification Source: ZFINInferred from mutant phenotypeⁱ
  • "Discontinuous organization and specification of the lateral floor plate in zebrafish."
    Schafer M., Kinzel D., Winkler C.
    Dev Biol 301:117-129(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPVDMQPHQG LYHYDNTSNQ PSRGLAPSVR SPYSSEASSV CVALSGGQSV 
        60         70         80         90        100
NSREMYNPSM APGACMEPYM RPPHAPPPHS MMGHRGMPPP EGMSGAPYCN 
       110        120        130        140        150
QNMMTSHHNL PHNQHTSELM ASGDASCFST PRSMLKLSKK RALSISPLSD 
       160        170        180        190        200
ASVDLQTVIR TSPNSLVAFV NSRCGPNNPS SYGHLSVGTM SPSLGFSSSI 
       210        220        230        240        250
NYSRPQGNIY SHPVPSCIGA PARLPPHNPR LHTPAKHTHL KTEPVLGSVM 
       260        270        280        290        300
DSINIKGLED HSEGDVASPS STGTQDPLLG LLEGRDDLDK EEKPEPEAIY 
       310        320        330        340        350
ETNCHWESCS KEFDTQEQLV HHINNEHIHG EKKEFVCHWK DCSREQRPFK 
       360        370        380        390        400
AQYMLVVHMR RHTGEKPHKC TFEGCNKAYS RLENLKTHLR SHTGEKPYVC 
       410        420        430        440        450
EHEGCNKAFS NASDRAKHQN RTHSNEKPYI CKIPGCTKRY TDPSSLRKHV 
       460        470        480        490        500
KTVHGPEAHI TKKHRGDTGP RPPGLTTAGQ SSELLIEKEE RNREDCKLLA 
       510        520        530        540        550
PDNTLKSQPS PGGQSSCSSE RSPLGSANNN DSGVEMNLNA AGSLEDLTTQ 
       560        570        580        590        600
EDSGNAGVSE SSATISSGGM CMSVQALKRL ENLKIDKLKQ IRRPTPPGRN 
       610        620        630        640        650
AGNKLPALSA TGEMMSMCAP SPLLSNRRVM ELSAPDMGGV TGMSCPPNDR 
       660        670        680        690        700
RGSGTSSLSS AYTVSRRSSM VSPYLSSRRS SDVSHCQSVM GGEVPGDPLS 
       710        720        730        740        750
PQNSQRAGLC QNSGGLPGLP SLTPAQQYSL KAKYAAATGG PPPTPLPNMD 
       760        770        780        790        800
QAGTPARHVG FLRECQGQPL PPFLQQGGTR RHSANAEYGT GVIYPHQAPG 
       810        820        830        840        850
NNTRRASDPV RSAADPQGLP KVQRFNSLSN VSLMSRRNAL QQCGSDAALS 
       860        870        880        890        900
RHMYSPRPPS ITENVMMEAM GMDGNTEGRQ QGNMIPGGDR SYMGYQHNPH 
       910        920        930        940        950
QASQLSPGQE SLGCIDQVYQ SQMQGQYQRE ESCSTGVMGQ TDIANNLLQQ 
       960        970        980        990       1000
AEYGMSTCQL SPSGPHYPSQ GDGSGPWGQT NQLHSPGMQY QGAGMQGQHY 
      1010       1020       1030       1040       1050
TQQGIYDPTS NPNLQRVTVK PEQFHPSMGG SSSCQNTKAL HQNRHNANMQ 
      1060       1070       1080       1090       1100
TYPLQGQGIM NRSSSASCDF HHSQMGTQPN QGGSFQSGTG INLALAESRR 
      1110       1120       1130       1140       1150
SQTPMHQMKE MMVRNYVQSQ QALLWEQQQE QSVSEKPDGM DMGQTQMMQH 
      1160       1170       1180       1190       1200
SPQHQQANQN LYPGNTYQGY PNQNLMSPQQ NRVPGSVKEQ MQSSCYGPDM 
      1210       1220       1230       1240       1250
IPRPPQVRKS LSRQNSLSQQ AGGAYLGSPP HLSPVHSTAS PRRGVRLPPV 
      1260       1270       1280       1290       1300
QQQQQQQQQH SENFNNNNNP MYYSGQIHMH HDLEKTPEGP CLAQQHLTSS 
      1310       1320       1330       1340       1350
DPTTKPTSIS YPDPAPMSNA LEHLDLENAQ IDFTSIIDDQ EPSSYSPINA 
      1360       1370       1380       1390       1400
PIGHNQCSSQ TSSRLTTPQN SITLPSGLSN MAIGDMSSML TSLAGENKYL 

NTLS                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ