UniProtKB - F1Q9B1 (F1Q9B1_DANRE)
Protein
Solute carrier organic anion transporter family member
Gene
slco2a1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- prostaglandin transmembrane transporter activity Source: GO_Central
- sodium-independent organic anion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- prostaglandin transport Source: GO_Central
- sodium-independent organic anion transport Source: GO_Central
Keywordsi
Biological process | Ion transportUniRule annotation, Transport |
Enzyme and pathway databases
Reactomei | R-DRE-879518, Transport of organic anions |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier organic anion transporter family memberUniRule annotation |
Gene namesi | Name:slco2a1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060606-3, slco2a1 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 88 – 109 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 153 – 178 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 190 – 218 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 238 – 263 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 305 – 332 | HelicalUniRule annotationAdd BLAST | 28 | |
Transmembranei | 344 – 368 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 380 – 400 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 496 – 513 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 533 – 550 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 587 – 607 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000061896, Expressed in liver and 21 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 610 | MFSInterPro annotationAdd BLAST | 610 | |
Domaini | 420 – 477 | Kazal-likeInterPro annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3626, Eukaryota |
GeneTreei | ENSGT01010000222271 |
HOGENOMi | CLU_008954_4_1_1 |
InParanoidi | F1Q9B1 |
OMAi | NLWLLMA |
TreeFami | TF317540 |
Family and domain databases
InterProi | View protein in InterPro IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004156, OATP |
PANTHERi | PTHR11388, PTHR11388, 1 hit |
Pfami | View protein in Pfam PF03137, OATP, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00805, oat, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
F1Q9B1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIYAKDIKK PKPSLFCNIK IFVLCHGLLQ LTQLLYSSYF KSTITTIERR
60 70 80 90 100
YGLDSLSSGT ISSLHEVGNT VLIAFVSYLG SRVHRPRFIG LGGLLMSISA
110 120 130 140 150
MILALPHFLS QPYTYDSVLH ASRQDMCYLR ANVTGAEACG QEDSRKLMDT
160 170 180 190 200
SKFWVLMATA QLLFGIGSVP IQPFGISYVD DFAGAGNSPL YIAILFAVSV
210 220 230 240 250
FGPSFGYLLG SVVLRIYVDV DKSSAGEALE LTPVDPRWVG AWWIGLLITS
260 270 280 290 300
GGLALTSIPY FFFPRSLHVE QSFNLEGEIM KEDPKKSESS LLDFFKMFPK
310 320 330 340 350
IFVRLLLSPL FMLLVLCQCC FSSVIAGLAT FLNKFLERQY SASAAYSSLL
360 370 380 390 400
IGALNLPSIA IGMVLGGLIM KRWGLSFRAI PRFSVVMLTI SVFCCVPLFF
410 420 430 440 450
MGCPTQDVAG VYPIKSNSTN GIHLTCSANC SCPISTFNPV CGEGNNIEYI
460 470 480 490 500
SPCHAGCANY TTDPKNPYRV QSYINCKCIP TGTAKPGPCS NTCPHYLLPV
510 520 530 540 550
MLLISLAGLI ASLTHNPIYM MVLRAVPPEE KSFAIGIQFL LLRVLTWLPA
560 570 580 590 600
PALFGMTIDS TCIWWKTACE KKQGCGYYDN NLLRNRYLGL QVGYKTLGIA
610 620
LLAFIGWKTH RSREYVLEKK PEGPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL935299 Genomic DNA No translation available. BX890558 Genomic DNA No translation available. CR385091 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000147789; ENSDARP00000115216; ENSDARG00000061896 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL935299 Genomic DNA No translation available. BX890558 Genomic DNA No translation available. CR385091 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000115216 |
Proteomic databases
PaxDbi | F1Q9B1 |
Genome annotation databases
Ensembli | ENSDART00000147789; ENSDARP00000115216; ENSDARG00000061896 |
Organism-specific databases
ZFINi | ZDB-GENE-060606-3, slco2a1 |
Phylogenomic databases
eggNOGi | KOG3626, Eukaryota |
GeneTreei | ENSGT01010000222271 |
HOGENOMi | CLU_008954_4_1_1 |
InParanoidi | F1Q9B1 |
OMAi | NLWLLMA |
TreeFami | TF317540 |
Enzyme and pathway databases
Reactomei | R-DRE-879518, Transport of organic anions |
Gene expression databases
Bgeei | ENSDARG00000061896, Expressed in liver and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004156, OATP |
PANTHERi | PTHR11388, PTHR11388, 1 hit |
Pfami | View protein in Pfam PF03137, OATP, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00805, oat, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1Q9B1_DANRE | |
Accessioni | F1Q9B1Primary (citable) accession number: F1Q9B1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | July 11, 2012 | |
Last modified: | February 10, 2021 | |
This is version 67 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |