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Entry version 67 (07 Oct 2020)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Lactase

Gene

lct

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1239NucleophilePROSITE-ProRule annotation1
Active sitei1714NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-glucosidase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LactaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lctImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-081104-434, lct

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1854 – 1878HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500567550424 – 1900Sequence analysisAdd BLAST1877

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1Q8B5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000060671, Expressed in intestine and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000080173

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili165 – 192Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0626, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001859_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1Q8B5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDSYHQL

Database of Orthologous Groups

More...
OrthoDBi
408001at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001360, Glyco_hydro_1
IPR018120, Glyco_hydro_1_AS
IPR033132, Glyco_hydro_1_N_CS
IPR017853, Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR10353, PTHR10353, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00232, Glyco_hydro_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00131, GLHYDRLASE1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00572, GLYCOSYL_HYDROL_F1_1, 2 hits
PS00653, GLYCOSYL_HYDROL_F1_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1Q8B5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKILGGFLS LGVLAIFWSY INADEQEFML LAGPLTTSQN LPSEEQYVFN
60 70 80 90 100
CRGPLPQQSK DYFLYLQRRG VTNFKVLLSW SHILPTGDAN QPHEETVMCF
110 120 130 140 150
KTLVQQLTES GIKPLLVLHR SAVPELFRAK YGGWGNPLLV QIFEQYAGFV
160 170 180 190 200
FSTFRDHVDT FVTFSHLHEL QHEELQNALQ SHENAYKVCH QQFKGLRLSL
210 220 230 240 250
GIRASHATSI YQMGSKIMTH VDFLSVHMQF NCKMQTALTE ELRKVQIVSG
260 270 280 290 300
QKSLLIYQLT VNDCDGYEHD FQPLTVVLGV LQNKDYKIIG CDITHVFEKL
310 320 330 340 350
DYEETPRSLQ KEDAMSVFNQ KSASAFSYQK VWEKFKTQTE AERDQFLSGS
360 370 380 390 400
FPVDFEWSVS SESFKVEGGS AEHGKGETIW DRFNHEAGVN ESILGCDSYH
410 420 430 440 450
KVDYDVYLLR GMMAPNYQFS ISWARIFPTG RKESFVEKGA AYYDKMINTL
460 470 480 490 500
LQSGIEPTVT LHHWDLPQAL QESGGWINDS IVEAFKEFSD FCFSRYGDRV
510 520 530 540 550
KTWVTFGSPW VVSNLGYGTG VYPPSIKDPV SASYKVTHNI LKSHAEAWHI
560 570 580 590 600
YNDKYRKLYG GKVGIALNSD WAEPRDPSSD QDVAAAERYL NFMLGWFAHP
610 620 630 640 650
IFVDGDYPAV LREQIEKKKK LCDQDLARLP VFTEAEKQRI QGTADFFGLN
660 670 680 690 700
HQTSRLISEN LTSCDAGPDN VGDFQAHIDP TWPTTSSDQI QSVPWGLRRL
710 720 730 740 750
LYYIFLEYTS ITKVPIYITG NGMPTEYTGD GINDTLRVDY LKAYINEAMK
760 770 780 790 800
AVHLDDVVVQ RFTVQSLMDG YEGPPGYTQR FGLHYVNFDD PDRPRTPKAS
810 820 830 840 850
AYYYSKVIER NGFAETAASP KMQIHGNQVE SRRLPSLPPS QVPSKSKVVW
860 870 880 890 900
EKFSPQTKFE RQLYHYGTFS EGFQWGVSSS AYQVEGGWNA DGKGPSVWDT
910 920 930 940 950
FTQKPGNIPN NANGDVACDS YNKVDEDLHM LRALKVKTYR FSLSWSRIFP
960 970 980 990 1000
NGYKSSLNQK GVDYYNRLID GLIANNITPM VTLYHWDLPQ ALQNIHWDNT
1010 1020 1030 1040 1050
EMIGLFNEYC DFCYATFGDR VKFWITFNEP QTIAWLGYGL GQIPPNVKQP
1060 1070 1080 1090 1100
GDAPYRVAHN LLKAHAQAYH TYDEKYRASQ GGLVSISLNA EWAEPLDVNI
1110 1120 1130 1140 1150
PREVVAADRA LQFQLGWFAH PIFKNGDYPE AMKWQVGNKS ELQGLKESRL
1160 1170 1180 1190 1200
PHFTDQEKAF IQGTADVFCI NTYTTKVVRH VTSRLNIESY QTDQDIEKDK
1210 1220 1230 1240 1250
ADGSENTAVS EQKAVAWGLR RLLIWLKEEY GNPEIYITEN GVATGTAITT
1260 1270 1280 1290 1300
DDTDRIFYLK TYVDEALKAH NLDGVRVKGY IASSLMDSFE WLNGYNVGYG
1310 1320 1330 1340 1350
LHHVDFKHSS RPRTPKRSAH LYFDIMRNNG FPMPVEEKML YGHFREGFVW
1360 1370 1380 1390 1400
STATAAYQIE GAWRADGKGL SIWDKFAHTS LKISQDENGD IACDSYNKIE
1410 1420 1430 1440 1450
EDIDNLKTLR VNHYRFSISW PRILPDGTNR KINEAGLNYY HRLIDVLLAA
1460 1470 1480 1490 1500
NIKPQVTLYH WDLPQALQDV GGWENDTIVD RFKDYADVVF NSLGDKVEFW
1510 1520 1530 1540 1550
ITINEPYNVA MVGHGYGSAA PGITFRPGTA PYIVAHNLIK AHAEAWHLYN
1560 1570 1580 1590 1600
DKYRAKHGGI VGITINSDWA EPRNPYKQED VDAARRVVQF QLGWFAHPVF
1610 1620 1630 1640 1650
NGDYSDLMKD IVRERSLAAG LPKSRLPEFT PEEVARIKGT HDYFGFNHYT
1660 1670 1680 1690 1700
TVLAYNFDYK DLQHYDADRG VGTVTDRTWL DSGSFWLKVT PVGFRKILNF
1710 1720 1730 1740 1750
IKEEYGDHTI YITENGVSER GPVNLNDIPR IHYYDNYINQ ALKAYMLDGV
1760 1770 1780 1790 1800
DIRGYAAWTL MDNLEWATGF DDRFGLFYVN RSDPNLPRIP KKSVWNYATI
1810 1820 1830 1840 1850
INCNGFISPE ERPHKCQVHE PEDDTPGITT IPPPVEELSI SFLGLEVSVS
1860 1870 1880 1890 1900
DAELALNVLF SLSIIAAVTV ILLVYGLVKA SKKQKHPAGE YIDLEKKDKF
Length:1,900
Mass (Da):216,637
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBC4B4298C86C2A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2KIT0A0A0G2KIT0_DANRE
Lactase
lct
1,898Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR394556 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000085738; ENSDARP00000080173; ENSDARG00000060671

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR394556 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000080173

Proteomic databases

PaxDbiF1Q8B5

Genome annotation databases

EnsembliENSDART00000085738; ENSDARP00000080173; ENSDARG00000060671

Organism-specific databases

ZFINiZDB-GENE-081104-434, lct

Phylogenomic databases

eggNOGiKOG0626, Eukaryota
GeneTreeiENSGT00940000155324
HOGENOMiCLU_001859_5_3_1
InParanoidiF1Q8B5
OMAiCDSYHQL
OrthoDBi408001at2759
TreeFamiTF314803

Gene expression databases

BgeeiENSDARG00000060671, Expressed in intestine and 7 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001360, Glyco_hydro_1
IPR018120, Glyco_hydro_1_AS
IPR033132, Glyco_hydro_1_N_CS
IPR017853, Glycoside_hydrolase_SF
PANTHERiPTHR10353, PTHR10353, 4 hits
PfamiView protein in Pfam
PF00232, Glyco_hydro_1, 4 hits
PRINTSiPR00131, GLHYDRLASE1
SUPFAMiSSF51445, SSF51445, 4 hits
PROSITEiView protein in PROSITE
PS00572, GLYCOSYL_HYDROL_F1_1, 2 hits
PS00653, GLYCOSYL_HYDROL_F1_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q8B5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q8B5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 7, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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