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Entry version 73 (02 Dec 2020)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Tudor domain-containing protein 1

Gene

tdrd1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tudor domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tdrd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070803-1, tdrd1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000007465, Expressed in testis and 18 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 119MYND-typeInterPro annotationAdd BLAST37
Domaini222 – 282TudorInterPro annotationAdd BLAST61
Domaini453 – 512TudorInterPro annotationAdd BLAST60
Domaini675 – 734TudorInterPro annotationAdd BLAST60
Domaini926 – 984TudorInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni828 – 853DisorderedSequence analysisAdd BLAST26
Regioni1061 – 1090DisorderedSequence analysisAdd BLAST30
Regioni1116 – 1137DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1152 – 1172Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158754

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010832_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YCQQKLP

Database of Orthologous Groups

More...
OrthoDBi
703199at2759

TreeFam database of animal gene trees

More...
TreeFami
TF343710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR002893, Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567, TUDOR, 4 hits
PF01753, zf-MYND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333, TUDOR, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304, TUDOR, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F1Q7S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPAFAQPMM RPNLPLRRPA TGPSSLSPRG PAPAIYEERL LASDVLDGPK
60 70 80 90 100
IDTMRKDISQ NCGDVLSSPQ TAVSMMGQVV KLCNYCSHQG NLRCTRCKKT
110 120 130 140 150
CYCSVACQTQ DWIAHRHVCK PSIPEVTSEK PKESKAVPYA NGLGGTQAKE
160 170 180 190 200
ISVDAQPKRI YRRDLHKKVV SKGSEIKGTV IDLRNPGMFS IHCQCEEMIE
210 220 230 240 250
SLKKITQQLQ KTYCSSFAQE YKPEVGELCA VKFSLDQNWY RAEIQAVDVA
260 270 280 290 300
RKTAGVFYID FGNEENVALD HIRPLSENID AVPPFALQCC IAGVKPLTGS
310 320 330 340 350
WTGECCIAVR QLIAGKSLTF TVLDIMNDGD LLAVDSLVST LGKHVSTFLI
360 370 380 390 400
DQSYAIKEDV PVKTQTEHSI NSLLTASFEN FKRFSGGKNE NSEARPPEPL
410 420 430 440 450
TQGVGDSFTA VVTHLQSPSE ILCQKLENAS IIQQLQMNLR VHCSNTAASD
460 470 480 490 500
DFRPAPGTVC CSLFSEDNQW YRAKVLAYSS EDRVCVGYID FGNSEEVELN
510 520 530 540 550
RLRPISKELL ALATQAIPCS LAGIKSLTDT WSDEAVLMLK HLVCNRFIRV
560 570 580 590 600
EILGKKDGRA LVSMIDESSD PQASVTELLV NMGFAAIESV ETKKNEPDPA
610 620 630 640 650
TSTEIPPLSQ PVVEKLEWTG AELPFDGQKV ELVISTLKSL DEFYCYNYSK
660 670 680 690 700
TDEHTLTEMS FELMKHCESE RAPFTPIVGE PCCALFTGDA RWYRAMVLEV
710 720 730 740 750
CGEGKARVCF VDYGNSCEVD AAHLKAITQS LLKLPFQAIR CWLAGVEPVE
760 770 780 790 800
GQWKKEAMLR FQALCAGQPL SGKVLSITEK GYGMELESAG QTVASVLISE
810 820 830 840 850
HLAKPYGQVR QPPQIQPAKP ASQIEDLPSL KPIDQNPSVE EPLKVSSKGA
860 870 880 890 900
ATTPEDLPVS SGCFPLNWKT LELSCSGTFQ PRVAAVISPS LFYIMNPGQV
910 920 930 940 950
NVEGLKAVMT DVAKYCSKQP VPNQCHPLPG ASCCAQFSGD KNWYRAVVLE
960 970 980 990 1000
VTTKHAHVIY SDYGNMETVP LSSILPITKE LLQHPFQIVR CALTGKEHFP
1010 1020 1030 1040 1050
VVWPTEVLEL FGIQLSGGVL ASFQGFDGTS NLLTLTQQSG QSDRDINSII
1060 1070 1080 1090 1100
LGALQKGQIK PSSKLPANVN EEKKDVEQKQ TQPISSNKAV EQTLSTNVEK
1110 1120 1130 1140 1150
PALDDQTLPL SVSLKHEEPE NMSKTKTAEE CTSTPDTVSS IESSHAAQSC
1160 1170
CCQELKQKMD RIEELVLLLV KQVGSR
Length:1,176
Mass (Da):129,166
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F340022DC4A5CF1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q58EK5TDRD1_DANRE
Tudor domain-containing protein 1
tdrd1 im:7155161
1,175Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QMA4A0A2R8QMA4_DANRE
Tudor domain-containing protein 1
tdrd1
1,176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QA40A0A2R8QA40_DANRE
Tudor domain-containing protein 1
tdrd1
1,149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3JAF7U3JAF7_DANRE
Tudor domain-containing protein 1
tdrd1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR932360 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001157500.1, NM_001164028.1
XP_009304904.1, XM_009306629.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000152981; ENSDARP00000127267; ENSDARG00000007465
ENSDART00000192628; ENSDARP00000150322; ENSDARG00000007465

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
553522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:553522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932360 Genomic DNA No translation available.
RefSeqiNP_001157500.1, NM_001164028.1
XP_009304904.1, XM_009306629.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000152981; ENSDARP00000127267; ENSDARG00000007465
ENSDART00000192628; ENSDARP00000150322; ENSDARG00000007465
GeneIDi553522
KEGGidre:553522

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56165
ZFINiZDB-GENE-070803-1, tdrd1

Phylogenomic databases

GeneTreeiENSGT00940000158754
HOGENOMiCLU_010832_0_0_1
OMAiYCQQKLP
OrthoDBi703199at2759
TreeFamiTF343710

Gene expression databases

BgeeiENSDARG00000007465, Expressed in testis and 18 other tissues

Family and domain databases

Gene3Di2.40.50.90, 4 hits
InterProiView protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF00567, TUDOR, 4 hits
PF01753, zf-MYND, 1 hit
SMARTiView protein in SMART
SM00333, TUDOR, 4 hits
PROSITEiView protein in PROSITE
PS50304, TUDOR, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q7S6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q7S6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: December 2, 2020
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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