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Entry version 52 (07 Apr 2021)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

Centrosomal protein 170B

Gene

cep170b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centrosomal protein 170BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cep170bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-131127-515, cep170b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1505 – 1526HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1Q7J5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000074636, Expressed in mature ovarian follicle and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1Q7J5, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000103052

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 73FHAInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni121 – 262DisorderedSequence analysisAdd BLAST142
Regioni323 – 395DisorderedSequence analysisAdd BLAST73
Regioni436 – 491DisorderedSequence analysisAdd BLAST56
Regioni543 – 579DisorderedSequence analysisAdd BLAST37
Regioni717 – 870DisorderedSequence analysisAdd BLAST154
Regioni936 – 1268DisorderedSequence analysisAdd BLAST333
Regioni1301 – 1358DisorderedSequence analysisAdd BLAST58
Regioni1463 – 1498DisorderedSequence analysisAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1416 – 1436Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi128 – 155PolyampholyteSequence analysisAdd BLAST28
Compositional biasi172 – 253PolyampholyteSequence analysisAdd BLAST82
Compositional biasi329 – 360PolyampholyteSequence analysisAdd BLAST32
Compositional biasi362 – 395PolarSequence analysisAdd BLAST34
Compositional biasi441 – 461PolarSequence analysisAdd BLAST21
Compositional biasi463 – 477PolyampholyteSequence analysisAdd BLAST15
Compositional biasi552 – 576PolyampholyteSequence analysisAdd BLAST25
Compositional biasi717 – 732PolarSequence analysisAdd BLAST16
Compositional biasi765 – 779PolyampholyteSequence analysisAdd BLAST15
Compositional biasi785 – 801PolyampholyteSequence analysisAdd BLAST17
Compositional biasi803 – 820PolarSequence analysisAdd BLAST18
Compositional biasi832 – 870PolarSequence analysisAdd BLAST39
Compositional biasi936 – 964PolarSequence analysisAdd BLAST29
Compositional biasi992 – 1013PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1014 – 1075PolarSequence analysisAdd BLAST62
Compositional biasi1096 – 1119PolarSequence analysisAdd BLAST24
Compositional biasi1134 – 1167PolarSequence analysisAdd BLAST34
Compositional biasi1182 – 1211PolarSequence analysisAdd BLAST30
Compositional biasi1301 – 1324PolarSequence analysisAdd BLAST24
Compositional biasi1338 – 1357PolyampholyteSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP170 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSH8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003940_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1Q7J5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHSAEIA

TreeFam database of animal gene trees

More...
TreeFami
TF328469

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029300, CEP170_C
IPR000253, FHA_dom
IPR008984, SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15308, CEP170_C, 1 hit
PF00498, FHA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240, FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1Q7J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVTSWFLVS SSGTRHRLPR EMIFVGREDC ELMLQSRSVD KQHAVINYDA
60 70 80 90 100
STDEHLVKDL GSLNGTFVND LRIPDQTYII LKLSDVIRFG YDSHIYILER
110 120 130 140 150
SQHKVPEEAL KHEKYTSQLQ LETLENKKQL QTGDRRRNSD STRVKSEKSE
160 170 180 190 200
RKNITDAPIS RPTPLYGQPS WWGEDDEDKA QRCDPSSQEQ HTENTKEGTK
210 220 230 240 250
HDLSISPDDL HDGQSKSSFI HKKEPSYFEI PTKENHPKAK STLTEEIPTK
260 270 280 290 300
DPDHKPPSVS PVVQGHASFT IEFDEQTPGK MKIKDHISKM SIRQRRNPSK
310 320 330 340 350
ESISRLTEVM SVENKVADWL VQSDTSLRSL EEPRSDQLLN KTFRDAHHNE
360 370 380 390 400
DPDVEEQEEI LSVSHSAAQK TPPQQEPVDY PSNQTADSKN QCRTDPKQAY
410 420 430 440 450
VIEFFDDAQR KKRSQSFTNN ISSPDFQSAL KNKLDKRKGT TLSSGHNPAT
460 470 480 490 500
QQFTIPLKDS DSPQRAESLR RETSEIRMST SEFSSRSVTK PFGSIGRRSK
510 520 530 540 550
ISQDFAAELL RVSKHSAASS WDSNTTWVKT SSALTTNNVV QESLSQSQNH
560 570 580 590 600
MIRSERVEDG DNTEGKPPKG QEEEDSLSDA GTYTIEAEGP DRDVAEARSL
610 620 630 640 650
IDQVFGVGEN SQTTAASAAD KAVVGDSEAH DSLLVNENSS GLIMGQFPSE
660 670 680 690 700
HSATAKSPAQ LQSMTSLTPG GTRWVSRWAS LADTYSDSGP ASGIFDVPTQ
710 720 730 740 750
VDLPSEAGER INMLNRSADY SENSQNSRSR RVLPQVPLKE KIETPPPMIH
760 770 780 790 800
IQPDPYLSTV EKSSQVQKHK WDPQKLNVQD DLDPDSLSDA SKSDDGSVIE
810 820 830 840 850
QCRKTPEVNQ KTWSRPSKTP SNQDEAKDQD TPQKFSTATL TRQYGKPSKS
860 870 880 890 900
NGAPPNIGQP SKNDSFGGDS LVSIVRQESY TKERASDDIQ LSRLPQISSQ
910 920 930 940 950
PMSKDVFKGV NSQDTHSYLK DTEDVLASLE AKILEQQVNN GRSHPEDSFS
960 970 980 990 1000
GESDTSSTVS GKNPCVSVPK KPIVLKGFLK GTGQYTREPK TSEDQSGMKE
1010 1020 1030 1040 1050
KSDPGKRFQL RRNHSSQDFG NEQQSPATRQ FPDTVSDQES SSLPYKKYTI
1060 1070 1080 1090 1100
PLQKEGTSKS KPTVTRSNSL SAPRPTRASM LRRGRLGEAS DNEGTETDRT
1110 1120 1130 1140 1150
SQNSDVNPSA NNRVAQTSKK LSRLDILALP RKRTGSFNTP SDTESSSASR
1160 1170 1180 1190 1200
TSFSNRSTES SSSVRKASVP DPRALLRKVT NAISRQPITR GRSSSAKYAS
1210 1220 1230 1240 1250
STASSRRRQK GSDYASTSED EYESNQSTPK HKRSHHSGAQ QSQPAGPVRA
1260 1270 1280 1290 1300
MPRSRDSEGE GQESDAFQNW TSHSAEIARL SQDLAKDLAI LAQEIHDVAG
1310 1320 1330 1340 1350
DTETQSGSQE QTEPAISTQE ELRHQIPESS LKVQKESPGA VEESEHTAED
1360 1370 1380 1390 1400
ENQANRRQDE AAVNSVLLNP VSQLSLAIRE NTEQLTHKIK VLFHNRRDVL
1410 1420 1430 1440 1450
GEIEAKISAE DDSLSMKTSN KEVASILKEL RRVQKQLEVI NSIMDPQGNP
1460 1470 1480 1490 1500
ELMRTFSSSA AAARGSRSAL RDNRSAGGGA GATPRARRMF RSTDRDGSMN
1510 1520 1530 1540 1550
QKCSVSALVA TGCLIGVGIL LAIVVIEKIK HEKEINEALN PHLSSTCCND

TDPNEQSR
Length:1,558
Mass (Da):172,561
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52A180CFD1492992
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X1WG67X1WG67_DANRE
Centrosomal protein 170B
cep170b
1,443Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABZ01060331 Genomic DNA No translation available.
CABZ01060332 Genomic DNA No translation available.
LO018432 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000112183; ENSDARP00000103052; ENSDARG00000074636

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01060331 Genomic DNA No translation available.
CABZ01060332 Genomic DNA No translation available.
LO018432 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103052

Proteomic databases

PaxDbiF1Q7J5

Genome annotation databases

EnsembliENSDART00000112183; ENSDARP00000103052; ENSDARG00000074636

Organism-specific databases

ZFINiZDB-GENE-131127-515, cep170b

Phylogenomic databases

eggNOGiENOG502QSH8, Eukaryota
GeneTreeiENSGT00940000157058
HOGENOMiCLU_003940_1_0_1
InParanoidiF1Q7J5
OMAiNHSAEIA
TreeFamiTF328469

Gene expression databases

BgeeiENSDARG00000074636, Expressed in mature ovarian follicle and 25 other tissues
ExpressionAtlasiF1Q7J5, baseline

Family and domain databases

CDDicd00060, FHA, 1 hit
InterProiView protein in InterPro
IPR029300, CEP170_C
IPR000253, FHA_dom
IPR008984, SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF15308, CEP170_C, 1 hit
PF00498, FHA, 1 hit
SMARTiView protein in SMART
SM00240, FHA, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q7J5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q7J5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 20, 2018
Last modified: April 7, 2021
This is version 52 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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