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Entry version 66 (02 Jun 2021)
Sequence version 2 (20 Jan 2016)
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Protein
Submitted name:

Collagen, type VI, alpha 1

Gene

col6a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-1442490, Collagen degradation
R-DRE-1650814, Collagen biosynthesis and modifying enzymes
R-DRE-186797, Signaling by PDGF
R-DRE-2022090, Assembly of collagen fibrils and other multimeric structures
R-DRE-216083, Integrin cell surface interactions
R-DRE-3000178, ECM proteoglycans
R-DRE-419037, NCAM1 interactions
R-DRE-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type VI, alpha 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col6a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070501-6, col6a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500646587521 – 1007Sequence analysisAdd BLAST987

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1Q6P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000074908, Expressed in swim bladder and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
F1Q6P3, 1 interactor

Molecular INTeraction database

More...
MINTi
F1Q6P3

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000103794

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 231VWFAInterPro annotationAdd BLAST198
Domaini607 – 791VWFAInterPro annotationAdd BLAST185
Domaini815 – 997VWFAInterPro annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni248 – 583DisorderedSequence analysisAdd BLAST336

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi297 – 324Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi358 – 372Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi391 – 422Basic and acidic residuesSequence analysisAdd BLAST32

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162889

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1Q6P3

Database of Orthologous Groups

More...
OrthoDBi
140989at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331207

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 5 hits
PF00092, VWA, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327, VWA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1Q6P3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALNGYILTA LCALWAGIFA QDVSRSSFRE CPVDLFFVLD TSESVALRAK
60 70 80 90 100
PPEFYINQIK TFTKLFIDEL KDLRQPCDRD VTWNSGALHY SDDTELVMGL
110 120 130 140 150
VDLNTKRADL KAAIDRIKYI GKGTYTDCAI KEGIAELLRA GSHYHENKYI
160 170 180 190 200
VVVTDGHPIT GYKEPCGGIQ EAANEARQHA IKVFAVAISP DQEDTRLSVI
210 220 230 240 250
ATDINYRQNF TAADNSRSTQ MSTIRSIIHM ITNETKDVCC SFDCIADGGP
260 270 280 290 300
QGPPGDPGQR GETGRPGMPG EKGDFGAQGN PGDPGPVGYQ GMKGDQGIKG
310 320 330 340 350
DKGERGHKGF KGDKGHHGLD GTDGRKGEPG FPGLPGCKGS PGPDGLQGES
360 370 380 390 400
GPKGDPGQYG RKGERGDPGR DGEPGRPGNY GPSGAKGDRG PRGANGDKGE
410 420 430 440 450
RGDDGPPGPD GPRGERGQGG EKGEQGSRGN RGPRGEPGEP GPRGEQGREG
460 470 480 490 500
SSGANGEPGE QGRAGQPGYR GDEGPAGPEG DKGPRGIKGA PGDRGLMGER
510 520 530 540 550
GEDGPPGNGT EGCAGFQGYP GPRGDPGAPG GKGTPGPKGD DGEPGDTGLD
560 570 580 590 600
NDRLGPPGTK GAKGHRGPEG KPGPPGPPGP QGADECEILD IIMKMCSCCE
610 620 630 640 650
CTCGPLDIAF IVDSSESIGA SNFAISKEFI VTIMDRLKLR QFGANESRIG
660 670 680 690 700
VVQYSGEKSQ EVVQLGDPNI KTLTDLKQAV KDLRWLAEAT YTGEALQYSL
710 720 730 740 750
RNMLSKLITE RSVVLVLTDG RSDTIRDKVP LNVLCGKGFK VGGVGVTDYA
760 770 780 790 800
ERKPNPEQLD EVVCKDDPRK GFSFVLNNFG LLLDDNFLQN LTEKICEDKK
810 820 830 840 850
CPTYTCPISF NDNTDVLIMM DSSASVGAKN FEMTKDFSRM LAKRFLSAER
860 870 880 890 900
GNFQVRIGVG QYSNNANLEA EFSTNATQVV AQIADAKFQN AGTQVTNALN
910 920 930 940 950
FAIERFRGGR TRKKKLLVFS DGRSQGVNSI QIEKAVEQVS NAGIELYVLA
960 970 980 990 1000
VGNQVNEAHL RTLVSRGRPY DNTYAYRHLF KVPDYRSLVT GVFYQTVSRK

ISLETRG
Length:1,007
Mass (Da):107,464
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6347A7FA6B9997E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR925698 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009304444.1, XM_009306169.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000110608; ENSDARP00000103794; ENSDARG00000074908

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
569755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:569755

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925698 Genomic DNA No translation available.
RefSeqiXP_009304444.1, XM_009306169.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiF1Q6P3, 1 interactor
MINTiF1Q6P3
STRINGi7955.ENSDARP00000103794

Proteomic databases

PaxDbiF1Q6P3

Genome annotation databases

EnsembliENSDART00000110608; ENSDARP00000103794; ENSDARG00000074908
GeneIDi569755
KEGGidre:569755

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1291
ZFINiZDB-GENE-070501-6, col6a1

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000162889
InParanoidiF1Q6P3
OrthoDBi140989at2759
TreeFamiTF331207

Enzyme and pathway databases

ReactomeiR-DRE-1442490, Collagen degradation
R-DRE-1650814, Collagen biosynthesis and modifying enzymes
R-DRE-186797, Signaling by PDGF
R-DRE-2022090, Assembly of collagen fibrils and other multimeric structures
R-DRE-216083, Integrin cell surface interactions
R-DRE-3000178, ECM proteoglycans
R-DRE-419037, NCAM1 interactions
R-DRE-8948216, Collagen chain trimerization

Gene expression databases

BgeeiENSDARG00000074908, Expressed in swim bladder and 19 other tissues

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR008160, Collagen
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF01391, Collagen, 5 hits
PF00092, VWA, 3 hits
SMARTiView protein in SMART
SM00327, VWA, 3 hits
SUPFAMiSSF53300, SSF53300, 3 hits
PROSITEiView protein in PROSITE
PS50234, VWFA, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q6P3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q6P3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: January 20, 2016
Last modified: June 2, 2021
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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