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Entry version 75 (02 Jun 2021)
Sequence version 3 (20 Jun 2018)
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Protein

Chloride channel protein

Gene

clcn2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotation, Transport
LigandChlorideUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clcn2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070705-19, clcn2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei86 – 108HelicalUniRule annotationAdd BLAST23
Transmembranei129 – 151HelicalUniRule annotationAdd BLAST23
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei203 – 222HelicalUniRule annotationAdd BLAST20
Transmembranei242 – 266HelicalUniRule annotationAdd BLAST25
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei324 – 346HelicalUniRule annotationAdd BLAST23
Transmembranei367 – 386HelicalUniRule annotationAdd BLAST20
Transmembranei433 – 454HelicalUniRule annotationAdd BLAST22
Transmembranei466 – 485HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000062427, Expressed in muscle organ and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000084693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini587 – 647CBSInterPro annotationAdd BLAST61
Domaini788 – 843CBSInterPro annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni885 – 979DisorderedSequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi892 – 939Polar residuesSequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chloride channel (TC 2.A.49) family. [View classification]UniRule annotation
Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. [View classification]ARBA annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0476, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155439

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006904_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1Q5F4

Database of Orthologous Groups

More...
OrthoDBi
1131873at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300522

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000644, CBS_dom
IPR002244, Cl-channel-2
IPR014743, Cl-channel_core
IPR001807, Cl-channel_volt-gated

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00654, Voltage_CLC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00762, CLCHANNEL
PR01113, CLCHANNEL2

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81340, SSF81340, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371, CBS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1Q5F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARDRAPQRV LQYQQTLMYG RYTQELGAYA KEEAARLRED GGLRRTTSVR
60 70 80 90 100
GQAPELLEYE KDPCAKCQVC TSRCKKFLIS RVGEDWIFLI LLGLLMALVS
110 120 130 140 150
WAMDYTIAFC QQAQKWMYRG LHSNMLLQYL AWVTYPVVLI TFSAGFTQIL
160 170 180 190 200
APQAVGSGIP EMKTILRGVV LKEYLTFKTF VAKVIGLTCA LGSGMPLGKE
210 220 230 240 250
GPFVHVASLC AALLSKFMAL FGGIYMEEPF EGNKNELRNT EMLSAACAVG
260 270 280 290 300
VGCCFAAPIG GVLFSIEVTS TFFAVRNYWR GFFAATFSAF IFRVLAVWNK
310 320 330 340 350
DEETITALFK TRFRLDFPFD LQELPAFAVL GIASGFGGAL YVYLNRIIVE
360 370 380 390 400
SMRKQKTINK FLLKKRLVYP AVVTLLISTL TFPPGFGQFM AGQLTQHESL
410 420 430 440 450
VALFDNLTWY KQGVAEEFEY SSHVPQAWKH PQVSVFITLL LFIVMKFWMS
460 470 480 490 500
AVATTMPVPC GAFMPVFLIG AAFGRLVGES MAAFFPDGIH ADSTVYPIVP
510 520 530 540 550
GGYAVVGAAA LSGAVTHTVS TAVIVFELTG QISHILPVMI AVILANAVAQ
560 570 580 590 600
SLQPSLYDSI IRIQKLPYLP ELGWGQEKYN IRVEDIMVRD VRYITLSSSY
610 620 630 640 650
RDLQEALVTG QLKTLALVES KESMILLGSI ERSQLQSLLS QQLGRPRRLE
660 670 680 690 700
YLRERAQDNG THVPTFTPDS PPKAGRGVRF LISTEESSYS PTLTNSQIPL
710 720 730 740 750
KSALKTVSAI SNTDSLNSSP NLSCGEPVKE LVESNAGPMA PKRSRRPKRV
760 770 780 790 800
KIPMADTADV EDDMSTAEIA EWEEQQLDEA VNFNNCKIDP APFQLVERTS
810 820 830 840 850
LHKTHTIFSL LGLDHAYVTS TGRLVGVVSL KELRKAIEGS VTVTGVKVRP
860 870 880 890 900
PLASFRDSGN SSSVSEVTEL HKLWSRHKSL SLPREINLPD LDDQTEQPSE
910 920 930 940 950
GSLVNETECT ELSSQNSPLH TDDQSELPYA DTSPQDEPLS QLPCDCPEVE
960 970
ESESVGEHCP ESTVVVGDGN PSPSDGQPE
Length:979
Mass (Da):108,012
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21EC67FFC445EDAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5PMN6A5PMN6_DANRE
Chloride channel, voltage-sensitive...
clcn2a clcn2
656Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640595 Genomic DNA No translation available.
FP236459 Genomic DNA No translation available.
LO017984 Genomic DNA No translation available.
LN610101 mRNA Translation: CEF79905.1

NCBI Reference Sequences

More...
RefSeqi
NP_001315638.1, NM_001328709.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000090260; ENSDARP00000084693; ENSDARG00000062427

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100150892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100150892

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640595 Genomic DNA No translation available.
FP236459 Genomic DNA No translation available.
LO017984 Genomic DNA No translation available.
LN610101 mRNA Translation: CEF79905.1
RefSeqiNP_001315638.1, NM_001328709.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000084693

Genome annotation databases

EnsembliENSDART00000090260; ENSDARP00000084693; ENSDARG00000062427
GeneIDi100150892
KEGGidre:100150892

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100150892
ZFINiZDB-GENE-070705-19, clcn2a

Phylogenomic databases

eggNOGiKOG0476, Eukaryota
GeneTreeiENSGT00940000155439
HOGENOMiCLU_006904_0_1_1
InParanoidiF1Q5F4
OrthoDBi1131873at2759
TreeFamiTF300522

Gene expression databases

BgeeiENSDARG00000062427, Expressed in muscle organ and 14 other tissues

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644, CBS_dom
IPR002244, Cl-channel-2
IPR014743, Cl-channel_core
IPR001807, Cl-channel_volt-gated
PfamiView protein in Pfam
PF00654, Voltage_CLC, 1 hit
PRINTSiPR00762, CLCHANNEL
PR01113, CLCHANNEL2
SUPFAMiSSF81340, SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371, CBS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q5F4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q5F4
Secondary accession number(s): A0A098DLM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 20, 2018
Last modified: June 2, 2021
This is version 75 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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