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Entry version 74 (31 Jul 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Trio Rho guanine nucleotide exchange factor a

Gene

trioa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Trio Rho guanine nucleotide exchange factor aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trioaImported
Synonyms:si:dkey-158b13.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060503-334 trioa

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F1Q551

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000019426 Expressed in 17 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1Q551 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 210CRAL-TRIOInterPro annotationAdd BLAST147
Domaini1302 – 1477DHInterPro annotationAdd BLAST176
Domaini1489 – 1601PHInterPro annotationAdd BLAST113
Domaini1665 – 1730SH3InterPro annotationAdd BLAST66
Domaini1979 – 2155DHInterPro annotationAdd BLAST177
Domaini2167 – 2282PHInterPro annotationAdd BLAST116
Domaini2539 – 2604SH3InterPro annotationAdd BLAST66
Domaini2674 – 2764Ig-likeInterPro annotationAdd BLAST91
Domaini2785 – 3039Protein kinaseInterPro annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni286 – 315DisorderedSequence analysisAdd BLAST30
Regioni1616 – 1660DisorderedSequence analysisAdd BLAST45
Regioni1757 – 1881DisorderedSequence analysisAdd BLAST125
Regioni1893 – 1917DisorderedSequence analysisAdd BLAST25
Regioni1935 – 1965DisorderedSequence analysisAdd BLAST31
Regioni2301 – 2426DisorderedSequence analysisAdd BLAST126
Regioni2450 – 2540DisorderedSequence analysisAdd BLAST91
Regioni2625 – 2648DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili764 – 794Sequence analysisAdd BLAST31
Coiled coili895 – 915Sequence analysisAdd BLAST21
Coiled coili953 – 973Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1616 – 1636PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1637 – 1660PolarSequence analysisAdd BLAST24
Compositional biasi1757 – 1778PolarSequence analysisAdd BLAST22
Compositional biasi1816 – 1845PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1846 – 1865PolarSequence analysisAdd BLAST20
Compositional biasi1940 – 1965PolarSequence analysisAdd BLAST26
Compositional biasi2404 – 2418PolarSequence analysisAdd BLAST15
Compositional biasi2459 – 2478PolarSequence analysisAdd BLAST20
Compositional biasi2512 – 2540PolarSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154766

KEGG Orthology (KO)

More...
KOi
K08810

Database of Orthologous Groups

More...
OrthoDBi
5761at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF104 PTHR22826:SF104, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1Q551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLHCGAVED TDSLSSWWNG NVASLLDNHR WQYAQTGNTL IQLPGKALTP
60 70 80 90 100
LLGFRRNEEM KAMEVLPILK EKVAFLSGGR DKRGGPVLTF PSRTNHDRIR
110 120 130 140 150
HEDLRRLIAY LAGIPSEDVC KHGFTVIVDM RGSKWDSIKP LLKILQESFP
160 170 180 190 200
CCIHIALIIK PDNFWQKQRT NFGSSKFEFE TTMVSLEGLS KVVDPSQLTA
210 220 230 240 250
DFEGSLDYNH EEWIEIRVAF EDFTGNARHL LARLEEMHET VTRKDLPQDL
260 270 280 290 300
DGARRMIEEH AALKKRVIKA PVEEVDNEGQ RLLQRIQSSE SYANRTVPVP
310 320 330 340 350
PGQREGQGQP NADTQGLVPR ITALLEKLHS TRQNLHQSWH IRKLQLDQCF
360 370 380 390 400
QLRLFEQDAE KMFDWIMHNK GLFLAGYTEI GNNHPHAMEL QTQHNHFAMN
410 420 430 440 450
CMNVYVNINR IMSVGNRLLE AGHYASQQIK QISGQLEQEW KAFAAALDER
460 470 480 490 500
SALLEMSATF HQKCDQYMSN VDSWCKACGE VDLPSELQEL EDAIHHHQGL
510 520 530 540 550
YEHITAAYSE VSQDGKALLD KLQRPLTPGS ADSLTASANY TKAVNHVLDI
560 570 580 590 600
IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL
610 620 630 640 650
SKHTGVGKSL HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC
660 670 680 690 700
DPEEIYQAAH QLEDRIQDFV RRVEQRKVLL DMSVAFHTHV KELWTWLEEL
710 720 730 740 750
QKELLDDVYA ESVEAVQDLI KRFGQQQQTT LQFTVNVIKE GEDLIQQLRD
760 770 780 790 800
LAISSNKTPH NSSINHIESV LQQLDEAQAQ MEELFQERKI KLELFLQLRI
810 820 830 840 850
FERDAIDIIS DLDSWNEELS QQMNEFDTED LTLAEQRLQH HADKALTMNN
860 870 880 890 900
LAFHVIHQGQ ELLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ
910 920 930 940 950
ELDVAAEQHR RHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL
960 970 980 990 1000
QEAEQLQREH EQFQHAIEKT HQSALQVQQK AEALLQANHY DMDMIRDCAE
1010 1020 1030 1040 1050
NVASHWQQLM LKMEDRLKLV NASVAFYKTS EQVCSVLESL EQEYKREEDW
1060 1070 1080 1090 1100
CGGADKLGPN CESDHVTPMI SKHLEQKEAF LKACTLARRN ADVFLKYMHR
1110 1120 1130 1140 1150
NSVSMPGMLS HVKAPEQQVK NILNELLQRE NRVLHFWTMR KRRLDQCQQY
1160 1170 1180 1190 1200
VVFERSAKQA LEWIHDTGEF YLSTHTSTGS SIHHTQELLK EHEDFHITAK
1210 1220 1230 1240 1250
QTKERVKLLI QLADGFCDKG HSHAAEIKKW VTAVDKRYRD FSLRMDKYRT
1260 1270 1280 1290 1300
SLEKALGISS DSNKASKDLQ LDIIPASAPG SEVKLRDAAH ELNEEKRKSA
1310 1320 1330 1340 1350
RRKDFIMAEL IQTEKAYVRD LRECMDTYLW EMTSGVEEIP PGIVNKEHII
1360 1370 1380 1390 1400
FGNMQDLYEF HHNIFLKELE KYEQLPEDVG HCFVTWADKF QMYVNYCKNK
1410 1420 1430 1440 1450
PDSTQLILEH AGGYFDEIQQ RHRLANSISS YLIKPVQRIT KYQLLLKELL
1460 1470 1480 1490 1500
TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE
1510 1520 1530 1540 1550
AFQVWDPKTL IRKGRERHLF LFEMSLIFSK EVKDSNGRSK YIYKSKLFTS
1560 1570 1580 1590 1600
ELGVTEHVEG DPCKFALWVG RTPTSDNKIV LKASGIENKQ DWIKHIREVI
1610 1620 1630 1640 1650
QERTVHLKGA LKEPIHIPKA STAKHKGRRD GEDLDSQGDG SSQPDTISLA
1660 1670 1680 1690 1700
SRTSQNTLDS DKLSGGCELT VVIHDFMAGN SNELTIRRGQ TVEVLERLHD
1710 1720 1730 1740 1750
KPDWCLVRTT DRSPALEGLV PCAMLCIAHS RSSMEMEGIF NHKDALSVCS
1760 1770 1780 1790 1800
NDAIMPGSSA TLQPGHVMGS QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD
1810 1820 1830 1840 1850
GHVKKLAHKH KKSRDVRKSA DAGSQKDSDD SAATPQDETL EERVRNEGLS
1860 1870 1880 1890 1900
SGTLSKSSSS GMQSCGEEEG EEGADAVPLP PPMAIQQHSL LQPDAQDDKT
1910 1920 1930 1940 1950
SSRLSVRPSS SETPSAAELV SAIEELVKSK MALEDRPSTL SVEQGDSSSP
1960 1970 1980 1990 2000
SFNPSDNSLL SSSSPIDEIE ERKTGFFKKR HYVLLELIET ERDYVRDLSL
2010 2020 2030 2040 2050
VVEGYMARMR EDGVPDDMKG KDKIVFGNIQ QIYDWHKDFF LGELEKCLED
2060 2070 2080 2090 2100
PDRLGPLFLK HERRLHMYIV YCQNKPKSEH IVSEYIDTYF EDLKQRLGHR
2110 2120 2130 2140 2150
LQITDLLIKP VQRIMKYQLL LKDFLKFSKK IGTDSIELEK AVEVMCIVPK
2160 2170 2180 2190 2200
RCNDMMNVGR LQGFDGKIVA QGRLLLQDTF MVAEPEGGLL NRMKERRVFL
2210 2220 2230 2240 2250
FEQIVIFSEP LDKKRGFSMP GYLYKYSIKV NCLGLEDSVD GDPCKFALTS
2260 2270 2280 2290 2300
RTSNSSKDAF ILHSSHPGVR QVWMLQISQI LESQRNFLNA LTSPIDYQRN
2310 2320 2330 2340 2350
HVEGPGVSGS GVQAGGSGGQ MMAPGGGVGV PAGPGSRSRP SRIPQPSRLP
2360 2370 2380 2390 2400
QPLRHHSPAL GPGAHEHDGP DKLSGMSPRP LSRGPSPSCT TEPEPKVKLP
2410 2420 2430 2440 2450
ASPHPKQTDS QQTESPAKEI PRATVAPLAL VKPRPGTVSP MASPLATPAF
2460 2470 2480 2490 2500
KDSIPPCSPG PKTGSSSFWS SVPASPASRP ASFTFPGDAC DTLSRPNHNQ
2510 2520 2530 2540 2550
SQRHSTHSKD ADRMSTCSST SEQSIQSTQS NGSESSSSSN ISTMLVTQDY
2560 2570 2580 2590 2600
VALKEDEINV GQGEVVQILA SNQQNMFLVF RAATEQCPAA EGWIPGYVLG
2610 2620 2630 2640 2650
HTSAIIPDAP DGTIKKSSSS WHTSLRIRKK SEKREKDNKK EAKLENGYRK
2660 2670 2680 2690 2700
SREGLTNKVS VKLLNPNYIY DVLPEFLVPL SDVTCDKGEC VTLRCKVCGR
2710 2720 2730 2740 2750
PKATVTWKGP EQKTLTNNGH FSIAYSETGE ATLRIVGVTS EDDGSYTCIA
2760 2770 2780 2790 2800
TNDIGSVASS ASLRVLGKNH DGIRVMWKDN FESFYTEVAE LGRGRFSVVK
2810 2820 2830 2840 2850
RCDQRGSKRT VAVKFVNKKL MKRDQVTHEF SVLQRLQHPH LVRLLDTFET
2860 2870 2880 2890 2900
SSSYALVLEM SDQGRLLDYI VSWGNLTEEK VAFYLRDILE ALQYLHNCRI
2910 2920 2930 2940 2950
VHLDLKPENL VVEQSPSQPL VKLTDFGDAV QLNSTPYVHP LLGSPEFAAP
2960 2970 2980 2990 3000
ELVLGDPVSL SSDLWSLGVL TYVMLSGASP FLDESVEETC LNICRLDFSF
3010 3020 3030 3040 3050
PDDYFQGVSQ AARDFMCLLL RMEPSKRPPA TSCLQEPWLR AGGGRRSAEC
3060 3070 3080
IDTSRLISFI DRRKHQNDLR PLTGIRAFLQ TRLQPRI
Length:3,087
Mass (Da):349,124
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF163ED1A9769CE93
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1LUA6TRIO_DANRE
Triple functional domain protein
trio si:dkey-158b13.2
3,028Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JI09J9JI09_DANRE
Trio Rho guanine nucleotide exchang...
trioa si:dkey-158b13.2
3,075Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX950864 Genomic DNA No translation available.
BX957244 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001097996.1, NM_001104526.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000087055; ENSDARP00000081489; ENSDARG00000019426

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
557667

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:557667

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950864 Genomic DNA No translation available.
BX957244 Genomic DNA No translation available.
RefSeqiNP_001097996.1, NM_001104526.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiF1Q551

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000087055; ENSDARP00000081489; ENSDARG00000019426
GeneIDi557667
KEGGidre:557667

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
557667
ZFINiZDB-GENE-060503-334 trioa

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00940000154766
KOiK08810
OrthoDBi5761at2759
TreeFamiTF318080

Gene expression databases

BgeeiENSDARG00000019426 Expressed in 17 organ(s), highest expression level in brain
ExpressionAtlasiF1Q551 baseline

Family and domain databases

CDDicd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO
PANTHERiPTHR22826:SF104 PTHR22826:SF104, 1 hit
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q551_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q551
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 31, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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