Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Tribbles pseudokinase 3

Gene

TRIB3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-1257604 PIP3 activates AKT signaling
R-CFA-165158 Activation of AKT2
R-CFA-199418 Negative regulation of the PI3K/AKT network
R-CFA-389357 CD28 dependent PI3K/Akt signaling
R-CFA-5218920 VEGFR2 mediated vascular permeability

Names & Taxonomyi

Protein namesi
Submitted name:
Tribbles pseudokinase 3Imported
Gene namesi
Name:TRIB3Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:47802 TRIB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1Q488

Expressioni

Gene expression databases

BgeeiENSCAFG00000006965 Expressed in 3 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035660

Structurei

3D structure databases

ProteinModelPortaliF1Q488
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 315Protein kinaseInterPro annotationAdd BLAST248

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00930000150878
InParanoidiF1Q488
KOiK19518
OMAiYTCKVYP
OrthoDBiEOG091G07JM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR024104 Tribbles/Ser_Thr_kinase_40
IPR024106 Tribbles_TRB3
PANTHERiPTHR22961 PTHR22961, 1 hit
PTHR22961:SF14 PTHR22961:SF14, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1Q488-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRATPLAAAA GAPSRRKRFK LDNELDTECP TRKPAGSGPQ SKLPPCPPPL
60 70 80 90 100
SPPPAPARAL PVTTASRLGP YILLEPEEGG RAYRALHCPT GTEYTCKVYP
110 120 130 140 150
VGEALAVLEP YSRLPPQGHV ARPADVVAGP RHLYTFFPRP HGDMHSLVRR
160 170 180 190 200
RRRLPEPEAA ALFRQMAAAL AHCHQHGLVL RDLKLRRFVF TDHQRTKLVL
210 220 230 240 250
ENLEDACVLT GPDDSLWDKH ACPAYVGPEI LSSRASYSGK AADVWSLGVA
260 270 280 290 300
LFTMLAGHYP FQDSEPVLLF GKIRRGAFAL PEGLSAPARC LVRCLLRREP
310 320 330 340 350
AERLTAAGIL LHPWLREDPI PSAPPRSHLW EADQVVPEGP GLEEAEEEEG

EGEAGLYG
Length:358
Mass (Da):39,171
Last modified:October 31, 2012 - v2
Checksum:i9CAE9B3E428DC075
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1PQT4F1PQT4_CANLF
Tribbles pseudokinase 3
TRIB3
343Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013862 Genomic DNA No translation available.
RefSeqiXP_005634961.1, XM_005634904.2
XP_542943.2, XM_542943.4

Genome annotation databases

EnsembliENSCAFT00000039763; ENSCAFP00000035660; ENSCAFG00000006965
GeneIDi485819
KEGGicfa:485819

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013862 Genomic DNA No translation available.
RefSeqiXP_005634961.1, XM_005634904.2
XP_542943.2, XM_542943.4

3D structure databases

ProteinModelPortaliF1Q488
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035660

Proteomic databases

PaxDbiF1Q488

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000039763; ENSCAFP00000035660; ENSCAFG00000006965
GeneIDi485819
KEGGicfa:485819

Organism-specific databases

CTDi57761
VGNCiVGNC:47802 TRIB3

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00930000150878
InParanoidiF1Q488
KOiK19518
OMAiYTCKVYP
OrthoDBiEOG091G07JM

Enzyme and pathway databases

ReactomeiR-CFA-1257604 PIP3 activates AKT signaling
R-CFA-165158 Activation of AKT2
R-CFA-199418 Negative regulation of the PI3K/AKT network
R-CFA-389357 CD28 dependent PI3K/Akt signaling
R-CFA-5218920 VEGFR2 mediated vascular permeability

Gene expression databases

BgeeiENSCAFG00000006965 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR024104 Tribbles/Ser_Thr_kinase_40
IPR024106 Tribbles_TRB3
PANTHERiPTHR22961 PTHR22961, 1 hit
PTHR22961:SF14 PTHR22961:SF14, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1Q488_CANLF
AccessioniPrimary (citable) accession number: F1Q488
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again