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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

MED11

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11UniRule annotation
Alternative name(s):
Mediator complex subunit 11UniRule annotation
Gene namesi
Name:MED11UniRule annotationImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:43119 MED11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF1Q215

Expressioni

Gene expression databases

BgeeiENSCAFG00000015894

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.UniRule annotation

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023380

Structurei

3D structure databases

ProteinModelPortaliF1Q215
SMRiF1Q215
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4057 Eukaryota
ENOG4111SCB LUCA
GeneTreeiENSGT00390000010184
InParanoidiF1Q215
OMAiMTPPMER
OrthoDBiEOG091G0YZ0
TreeFamiTF318328

Family and domain databases

InterProiView protein in InterPro
IPR019404 Mediator_Med11
PANTHERiPTHR22890 PTHR22890, 1 hit
PfamiView protein in Pfam
PF10280 Med11, 1 hit

Sequencei

Sequence statusi: Complete.

F1Q215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYSLANER LRALEDIERE IGAILQNAGT VILELSKEKT NERLLDRQAA
60 70 80 90 100
AFTASVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA
110
RLKLSDVART CEQMLEN
Length:117
Mass (Da):13,129
Last modified:October 31, 2012 - v2
Checksum:iD01CAA8D211D6FC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03003593 Genomic DNA No translation available.
RefSeqiXP_849319.2, XM_844226.3

Genome annotation databases

EnsembliENSCAFT00000025184; ENSCAFP00000023380; ENSCAFG00000015894
GeneIDi607526

Similar proteinsi

Entry informationi

Entry nameiF1Q215_CANLF
AccessioniPrimary (citable) accession number: F1Q215
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: July 18, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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