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Protein
Submitted name:

Rho guanine nucleotide exchange factor 3

Gene

ARHGEF3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-193648 NRAGE signals death through JNK
R-CFA-194840 Rho GTPase cycle
R-CFA-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 3Imported
Gene namesi
Name:ARHGEF3Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:38084 ARHGEF3

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiF1Q023

Expressioni

Gene expression databases

BgeeiENSCAFG00000008061 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011905

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 428DHInterPro annotationAdd BLAST183
Domaini415 – 573PHInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiKOG4305 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000119193
InParanoidiF1Q023
OMAiGWLPCLS
OrthoDBiEOG091G05S7
TreeFamiTF328974

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

F1Q023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRYRGARAGS SPASSQGPRR GAEGSALQQW PPPAHVAAGL PAPAPAPGRP
60 70 80 90 100
GPAPPGEPPP QPPRPPQPSA LQPRGPSRAA PRKKAWANHA VSLDSSTVMN
110 120 130 140 150
QCVFRGMEEN KERPRRQRQT NFPMFPSPKA WNFRGRKRKQ STQDEDAVSL
160 170 180 190 200
CSLDISEPSN KRVKPLSRVT SLANLIPPVK ATPLKRFSQT LQRSISFRSE
210 220 230 240 250
SRPDILAPRP WSRNAAPSST KRRDSKLWSE TFDVCVNQML PSKEIKRQEA
260 270 280 290 300
IFELSQGEED LIEDLKLAKK AYHDPMLKLS IMTEQELNQI FGTLDSLIPL
310 320 330 340 350
HEELLSQLRD ARKPDGSTEH VGPILVGWLP CLSSYDSYCS NQVAAKALLD
360 370 380 390 400
HKKQDHRVQD FLQRCLESPF SRKLDLWNFL DIPRSRLVKY PLLLREILRH
410 420 430 440 450
TPNDNPDQQH LEEAINIIQG IVAEINTKTG ESECRYYKER LLYLEEGQKD
460 470 480 490 500
SLIDNSRVLC CHGELKNNRG VKLHVFLFQE VLVITRAVTH NEQLCYQLYR
510 520 530 540 550
QPIPVKDLLL EDLQDGEVRL GGSLRGAFSN NERIKNFFRV SFKNGSQSQT
560 570 580 590 600
HSLQANDTFN KQQWLNCIRQ AKETVLCAAG QAGDLDSEGP FLNPATGSRE
610 620 630 640 650
PQGETKLEQM DQSDSESDCS MDTSEVSLDY ERMEQTDSSC GNSRHVESNV
Length:650
Mass (Da):73,229
Last modified:October 31, 2012 - v2
Checksum:i43D2EDDF8CC7936D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03012169 Genomic DNA No translation available.
AAEX03012170 Genomic DNA No translation available.
AAEX03012171 Genomic DNA No translation available.
AAEX03012172 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000012861; ENSCAFP00000011905; ENSCAFG00000008061

Similar proteinsi

Entry informationi

Entry nameiF1Q023_CANLF
AccessioniPrimary (citable) accession number: F1Q023
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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