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Protein
Submitted name:

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-6805567 Keratinization
R-CFA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Submitted name:
Keratin, type I cytoskeletal 10Imported
Gene namesi
Name:KRT10Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:42516 KRT10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiF1PYU9

Expressioni

Gene expression databases

BgeeiENSCAFG00000016007 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 450IF rodInterPro annotationAdd BLAST315

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 174Sequence analysisAdd BLAST35
Coiled coili186 – 213Sequence analysisAdd BLAST28
Coiled coili235 – 287Sequence analysisAdd BLAST53
Coiled coili301 – 328Sequence analysisAdd BLAST28
Coiled coili348 – 375Sequence analysisAdd BLAST28
Coiled coili394 – 425Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGJX Eukaryota
ENOG410YDXS LUCA
GeneTreeiENSGT00900000140820
OMAiQGQPRDY
OrthoDBiEOG091G087I
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1PYU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRYSSSKQ YSSSRSGGGG GGGGGSSFRI SSSKGSIGGG FSSGGFSGGS
60 70 80 90 100
FSRGSSGGGC FGGSSGGYGG LGGGFGGGNF GGGYGSSSFG GGYGGVSFGG
110 120 130 140 150
GSFGGGSFGG GGFSGGSFGG YGGGYGGDGG LLSGNEKVTM QNLNDRLASY
160 170 180 190 200
LDKVRALEES NYELEGKIKE WYEKHGNSSQ RAPRDYSKYY QTIEDLKNQI
210 220 230 240 250
LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA DINGLRRVLD
260 270 280 290 300
ELTLTKADLE MQIESLTEEL AYLKKNHEEE MRDLQNVSTG DVNVEMNAAP
310 320 330 340 350
GVDLTELLNN MRNQYEQLAE QNRKDAEAWF NEKSKELTTE INSNIEQMSS
360 370 380 390 400
HKSEITELRR TVQGLEIELQ SQLALKQSLE GSLAETEGRY CVQLSQIQAQ
410 420 430 440 450
ISSLEEQLQQ IRAETECQNA EYQQLLDIKI RLENEIQTYR SLLEGEGSSG
460 470 480 490 500
GGGYGGGRGG GSSGGGYGGS SGGGYGGSSG GGGYGGGSSG GGGHSGGHSG
510 520 530 540 550
GHSGSSGGGY GGGSSSGGGG YGGGSSGGGG SHGGSSGGGY GGGSSSSGGH
560
KSSSSGSVGE SSSKGPRY
Length:568
Mass (Da):57,685
Last modified:October 31, 2012 - v2
Checksum:i91D6BBAF5D2090CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006462 Genomic DNA No translation available.
RefSeqiXP_013972065.1, XM_014116590.1
UniGeneiCfa.16768

Genome annotation databases

EnsembliENSCAFT00000025391; ENSCAFP00000023577; ENSCAFG00000016007
GeneIDi491006

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006462 Genomic DNA No translation available.
RefSeqiXP_013972065.1, XM_014116590.1
UniGeneiCfa.16768

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiF1PYU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000025391; ENSCAFP00000023577; ENSCAFG00000016007
GeneIDi491006

Organism-specific databases

CTDi3858
VGNCiVGNC:42516 KRT10

Phylogenomic databases

eggNOGiENOG410IGJX Eukaryota
ENOG410YDXS LUCA
GeneTreeiENSGT00900000140820
OMAiQGQPRDY
OrthoDBiEOG091G087I
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-CFA-6805567 Keratinization
R-CFA-6809371 Formation of the cornified envelope

Gene expression databases

BgeeiENSCAFG00000016007 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1PYU9_CANLF
AccessioniPrimary (citable) accession number: F1PYU9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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