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Protein
Submitted name:

KRAS proto-oncogene, GTPase

Gene

KRAS

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-1169092 Activation of RAS in B cells
R-CFA-1250347 SHC1 events in ERBB4 signaling
R-CFA-1433557 Signaling by SCF-KIT
R-CFA-171007 p38MAPK events
R-CFA-179812 GRB2 events in EGFR signaling
R-CFA-180336 SHC1 events in EGFR signaling
R-CFA-186763 Downstream signal transduction
R-CFA-1963640 GRB2 events in ERBB2 signaling
R-CFA-210993 Tie2 Signaling
R-CFA-2179392 EGFR Transactivation by Gastrin
R-CFA-2424491 DAP12 signaling
R-CFA-2871796 FCERI mediated MAPK activation
R-CFA-375165 NCAM signaling for neurite out-growth
R-CFA-5218921 VEGFR2 mediated cell proliferation
R-CFA-5621575 CD209 (DC-SIGN) signaling
R-CFA-5654688 SHC-mediated cascade:FGFR1
R-CFA-5654693 FRS-mediated FGFR1 signaling
R-CFA-5654699 SHC-mediated cascade:FGFR2
R-CFA-5654700 FRS-mediated FGFR2 signaling
R-CFA-5654704 SHC-mediated cascade:FGFR3
R-CFA-5654706 FRS-mediated FGFR3 signaling
R-CFA-5654712 FRS-mediated FGFR4 signaling
R-CFA-5654719 SHC-mediated cascade:FGFR4
R-CFA-5658442 Regulation of RAS by GAPs
R-CFA-5673000 RAF activation
R-CFA-5673001 RAF/MAP kinase cascade
R-CFA-5674135 MAP2K and MAPK activation
R-CFA-5675221 Negative regulation of MAPK pathway
R-CFA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-CFA-8851805 MET activates RAS signaling
R-CFA-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyi

Protein namesi
Submitted name:
KRAS proto-oncogene, GTPaseImported
Gene namesi
Name:KRASImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:42508 KRAS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1PXZ9

Expressioni

Gene expression databases

BgeeiENSCAFG00000011428

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009756

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
InParanoidiF1PXZ9
KOiK07827
OMAiQSWAVNM
OrthoDBiEOG091G0UAU
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

F1PXZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ
160 170 180
GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SKTKCIIM
Length:188
Mass (Da):21,439
Last modified:May 3, 2011 - v1
Checksum:iB1B6C319BB259861
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03015190 Genomic DNA No translation available.
RefSeqiXP_003433609.1, XM_003433561.2
UniGeneiCfa.3678

Genome annotation databases

EnsembliENSCAFT00000010525; ENSCAFP00000009756; ENSCAFG00000011428
GeneIDi403871
KEGGicfa:403871

Similar proteinsi

Entry informationi

Entry nameiF1PXZ9_CANLF
AccessioniPrimary (citable) accession number: F1PXZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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