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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 74PROSITE-ProRule annotation
Disulfide bondi81 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiF1PUV8

Expressioni

Gene expression databases

BgeeiENSCAFG00000002078 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000003059

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 99TNFR-CysInterPro annotationAdd BLAST42
Repeati58 – 99TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini383 – 466DeathInterPro annotationAdd BLAST84

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHQ6 Eukaryota
ENOG410YYKW LUCA
GeneTreeiENSGT00760000119204
InParanoidiF1PUV8
OMAiLMEDTAQ
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

CDDicd08778 Death_TNFRSF21, 1 hit
cd10583 TNFRSF21, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022330 TNFR_21
IPR034037 TNFRSF21_death
IPR034034 TNFRSF21_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01971 TNFACTORR21
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1PUV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LGFLSTTTAQ LEQKASNLIG KYHHVDRATG QVLTCDKCPA GTYVSEHCTN
60 70 80 90 100
TSLRVCSSCP VGTFTRHENG IEKCHDCSQP CPWPMVEKLP CAALTDRECA
110 120 130 140 150
CPPGMFQFNG TCAPHTVCPV GWGVRKKGTE TEDVRCKQCA RGTFSDVPSS
160 170 180 190 200
VMKCKAYTDC LSQNLVVIKP GTKEADNVCG TLPPFSSTTS PTPGTTIFSH
210 220 230 240 250
PEHMESHEVP SSTYVPKGMN STESNSSASV RPKVPSGIQE GTVPDNTSSA
260 270 280 290 300
RGEEGMNKTL PNLQVVNHQQ GPHHRHILKL LPSMEATGGE KSSTPIKGLK
310 320 330 340 350
RTHPRQNLHK HFDINEHLPW MIVLFLLLVL VVIVVCSIRK SSRTLKKGPR
360 370 380 390 400
QDPSTIVEKA GLKKSVTPTQ NREKWIYYCN GHGIDILKLV AAQVGSQWKD
410 420 430 440 450
IYQFLCNASE REVAAFSNGY TADHERAYAA LQHWTIRGPE ASLAQLISAL
460 470 480 490 500
RQHRRNDVVE KIRGLMEDTA QLETDKLALP MSPSPLSPSP IPSPNTKLEN
510 520 530 540 550
SALLTVEPSP LDKNKGFFVD ESEPLLRCDS TSSGSSALSR TGSFITKEKK
560 570 580 590 600
DTVLRQVRLD PCDLQPIFDD MLHILNPEEL RVIEEIPQAE DKLDRLFEII
610 620
GVKSQEASQT LLDSVYSHLP DLL
Length:623
Mass (Da):68,626
Last modified:October 31, 2012 - v2
Checksum:i75F94A9A2179CE5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008376 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000003293; ENSCAFP00000003059; ENSCAFG00000002078

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008376 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000003059

Proteomic databases

PaxDbiF1PUV8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000003293; ENSCAFP00000003059; ENSCAFG00000002078

Phylogenomic databases

eggNOGiENOG410IHQ6 Eukaryota
ENOG410YYKW LUCA
GeneTreeiENSGT00760000119204
InParanoidiF1PUV8
OMAiLMEDTAQ
OrthoDBiEOG091G03XW
TreeFamiTF331157

Gene expression databases

BgeeiENSCAFG00000002078 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd08778 Death_TNFRSF21, 1 hit
cd10583 TNFRSF21, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022330 TNFR_21
IPR034037 TNFRSF21_death
IPR034034 TNFRSF21_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01971 TNFACTORR21
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50050 TNFR_NGFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1PUV8_CANLF
AccessioniPrimary (citable) accession number: F1PUV8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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