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Protein

Tyrosine-protein kinase

Gene

SYK

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei400ATPUniRule annotation1
Active sitei492Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 383ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-114604 GPVI-mediated activation cascade
R-CFA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-CFA-2029485 Role of phospholipids in phagocytosis
R-CFA-2424491 DAP12 signaling
R-CFA-2454202 Fc epsilon receptor (FCERI) signaling
R-CFA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-CFA-2871796 FCERI mediated MAPK activation
R-CFA-2871809 FCERI mediated Ca+2 mobilization
R-CFA-354192 Integrin alphaIIb beta3 signaling
R-CFA-9020558 Interleukin-2 signaling
R-CFA-912631 Regulation of signaling by CBL
R-CFA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:SYKImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:47021 SYK

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1PSC8
PRIDEiF1PSC8

Expressioni

Gene expression databases

BgeeiENSCAFG00000002171 Expressed in 3 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000003166

Structurei

3D structure databases

ProteinModelPortaliF1PSC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 106SH2InterPro annotationAdd BLAST93
Domaini167 – 258SH2InterPro annotationAdd BLAST92
Domaini369 – 629Protein kinaseInterPro annotationAdd BLAST261

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH0T Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118799
InParanoidiF1PSC8
KOiK05855
OMAiKPFNRPP
OrthoDBiEOG091G07KU
TreeFamiTF351629

Family and domain databases

CDDicd09938 SH2_N-SH2_Zap70_Syk_like, 1 hit
Gene3Di1.10.930.10, 1 hit
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR023420 Kinase_SYK/ZAP-70_inter-SH2_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035838 SYK/ZAP-70_N_SH2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR012234 Tyr_kinase_non-rcpt_SYK/ZAP70
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 2 hits
PIRSFiPIRSF000604 TyrPK_SYK, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F1PSC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSTADSAN HLPFFFGNIT REEAEDYLVQ GGMSDGLYLL RQSRNYLGGF
60 70 80 90 100
ALSVAHGRKA HHYTIEREMN GTYAIAGGRT HGSPAELCHY HSQESDGLVC
110 120 130 140 150
LLKQPFHRPP GVQPKTGPFE DLKESLIREY VKQTWNLQGQ ALEQAIISQK
160 170 180 190 200
PQLEKLIATT AHEKMPWFHG KISRVESEQI VMIGSKTNGK FLIRDRNDNG
210 220 230 240 250
SYALCLLHEG KVLHYRIDKD KTGKLSIPDG KKFDTLWQLV EHYSYKPDGL
260 270 280 290 300
LRVLTVPCQK IGGQPGNINF GARAPLPGAH PATWSAGGII SRIKSYTFPK
310 320 330 340 350
PGHRKAASST GSRPESSFNP YEPDRGPWAT DRDAQREALP MDTEVYESPY
360 370 380 390 400
ADPEEIRPKE VYLDRKLLTL EDNELGSGNF GTVKKGYYQM KKVVKTVAVK
410 420 430 440 450
ILKNEANDPA LKDELLAEAN VMQQLDNPYI VRMIGICEAE SWMLVMEMAE
460 470 480 490 500
LGPLNKYLQQ NRHVKDKNII ELVHQVSMGM KYLEESNFVH RDLAARNVLL
510 520 530 540 550
VTQHYAKISD FGLSKALRAD ENYYKAQTHG KWPVKWYAPE CINYYKFSSK
560 570 580 590 600
SDVWSFGVLM WEAFSYGQKP YRGMKGSEVS AMLEKGERMG CPAGCPREMY
610 620 630
ELMKLCWTYE VDRRPGFEAV ELRLRNYYYD VVN
Length:633
Mass (Da):71,892
Last modified:May 3, 2011 - v1
Checksum:i887DAA6790DA5381
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1PMP8F1PMP8_CANLF
Spleen associated tyrosine kinase
SYK
282Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000634 Genomic DNA No translation available.
RefSeqiXP_005616010.1, XM_005615953.2

Genome annotation databases

EnsembliENSCAFT00000003411; ENSCAFP00000003166; ENSCAFG00000002171
KEGGicfa:484196

Similar proteinsi

Entry informationi

Entry nameiF1PSC8_CANLF
AccessioniPrimary (citable) accession number: F1PSC8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 12, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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