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Entry version 54 (02 Jun 2021)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Dispatched RND transporter family member 2

Gene

DISP2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-5362798, Release of Hh-Np from the secreting cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dispatched RND transporter family member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DISP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 30

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:39967, DISP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei170 – 191HelicalSequence analysisAdd BLAST22
Transmembranei492 – 509HelicalSequence analysisAdd BLAST18
Transmembranei515 – 533HelicalSequence analysisAdd BLAST19
Transmembranei545 – 568HelicalSequence analysisAdd BLAST24
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Transmembranei620 – 639HelicalSequence analysisAdd BLAST20
Transmembranei706 – 724HelicalSequence analysisAdd BLAST19
Transmembranei967 – 986HelicalSequence analysisAdd BLAST20
Transmembranei992 – 1014HelicalSequence analysisAdd BLAST23
Transmembranei1021 – 1044HelicalSequence analysisAdd BLAST24
Transmembranei1064 – 1087HelicalSequence analysisAdd BLAST24
Transmembranei1099 – 1118HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1PRY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000009083, Expressed in large intestine and 16 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000013370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini496 – 645SSDInterPro annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 141DisorderedSequence analysisAdd BLAST141
Regioni1140 – 1194DisorderedSequence analysisAdd BLAST55
Regioni1232 – 1340DisorderedSequence analysisAdd BLAST109
Regioni1353 – 1403DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 51Polar residuesSequence analysisAdd BLAST15
Compositional biasi64 – 86Polar residuesSequence analysisAdd BLAST23
Compositional biasi1174 – 1192Polar residuesSequence analysisAdd BLAST19
Compositional biasi1232 – 1252Polar residuesSequence analysisAdd BLAST21
Compositional biasi1288 – 1311Polar residuesSequence analysisAdd BLAST24
Compositional biasi1354 – 1368Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3664, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004076_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1PRY8

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMGFEPR

Database of Orthologous Groups

More...
OrthoDBi
1156918at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324144

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000731, SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12349, Sterol-sensing, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156, SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1PRY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAGSGSSSG GPAPGPAPGP GPEGEQRPKG EPLASDGSSP DRSQSKAVAS
60 70 80 90 100
EASPEKSCCP HSGPLEDPSS SSEPPPATST LQPVRPTSPL APAHFTYPRA
110 120 130 140 150
PQEYRGDSSL PGLGDRAALC SHGSSLSPSP APSQRDGAWK PPSVQHHVVS
160 170 180 190 200
VRQERAFRMP KSYSQLIAEW PVAVLLLCLA VIILCTLAGL LGDRLPDFSK
210 220 230 240 250
PLLGFEPRDT DVGRKLVVWR ALQTLTGPRK LLSLSPDLEQ NSSNLHTTLS
260 270 280 290 300
PTPWSSAQEG LIRPRRMVEP LEDRGQDSFF CGPPEKSYAQ LVFMSTSAGS
310 320 330 340 350
LWNLHAIHSM CRMEQDQIRS HTHFGALCQR TEANKCCPSW SLGNYVAVLS
360 370 380 390 400
NRSSCLDTTQ ADAARTLALL RACATYYHRG ALVPSCLGPG QDKPPHCVQV
410 420 430 440 450
PTKCSRNSAI YQLLHFLLDR DFLSPQTADY QVPSLKYSLL FLPTPKGASM
460 470 480 490 500
MGIYLDRLAT PWGLSDNYTS ITGMDLGLKQ ELLRHYLAQD TVYPLLALAA
510 520 530 540 550
IFLSIALYLR SLFLTLMVLL GVLGSLLVAF FLYRVAFRMA YFPFVNLAAF
560 570 580 590 600
VLLSSVCANH TLIFFDLWRL SKSQLPSGGL AQRVGRTMHH FGYLLLVSGL
610 620 630 640 650
TTAAAFYASY LSRLPAVRCF ALYMGTAVLA HLALTLAWLP ASAVLHERYL
660 670 680 690 700
ARGCASRAQG QRGGSAPRRL ALALQRRLRG LRRAAASTSR LLFQRLLPCG
710 720 730 740 750
VIKFRYIWIC WFAALAAGGA YIAGVSPRLR LPTLPPPRGQ VFRPSHPFER
760 770 780 790 800
FDAEYRQQFL FERLPQGEGG HMPVVLVWGI LPVDTGDPLD PRSNSSLVSD
810 820 830 840 850
PAFSASGPEA QRWLLALCHA ARNQSFFGAQ PEGWPTLCFM EALQRWVESP
860 870 880 890 900
GCARLGPGLC CGHSGFPWAP QLFLHCLKMM ALEQGPNNTR DLGPRFDTHG
910 920 930 940 950
SLAALVLQFQ TNFQYSPDYS QTHHFYTEVS HWLAAELGRA PPGLHRGWFT
960 970 980 990 1000
SHLELYSLQH SLSTEPAVVL GLALALAFAT LLLGTWNVPL SLFSVAAVAG
1010 1020 1030 1040 1050
TVLLTVGLLV LLEWQLNTAE ALFLSASVGL SVDFTVNYCI SYHLCPHPDR
1060 1070 1080 1090 1100
LSRVAFSLRQ TSCATAVGAA ALFAAGVLML PATVLLYRKL GIVIMMVKCV
1110 1120 1130 1140 1150
SCGFASFFFQ SLCCFFGPEK NCGQILWPCA HLPWDAGTGE PSGEKAGRPR
1160 1170 1180 1190 1200
SGPVGGAPGS CSEQYELQPL ARRRSPSFDT STATSKLSHR PSVLSEDLQL
1210 1220 1230 1240 1250
HDGPCCPRPP LAPASPRELF LDHQAVFSQC PALQTSSPYK QAGPSPKTQG
1260 1270 1280 1290 1300
RKDSPMQKAE PVQASPEAST HSPKPKAVEP PDCLCSSAST LEGLSVSDET
1310 1320 1330 1340 1350
CLSTSEPSAR VPDSVGASPD DLDETEQTVP ERGQLNGKRD TLWLALRETV
1360 1370 1380 1390 1400
YDPSLPASHQ SSSSWKGRGA PGDGSPVVLP NSQPDLPDVW LRRPSTHTSG

YSS
Length:1,403
Mass (Da):152,089
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE81E2FE9DED6E088
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03016065 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003640083.1, XM_003640035.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000014457; ENSCAFP00000013370; ENSCAFG00000009083

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100856240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cfa:100856240

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03016065 Genomic DNA No translation available.
RefSeqiXP_003640083.1, XM_003640035.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000013370

Proteomic databases

PaxDbiF1PRY8

Genome annotation databases

EnsembliENSCAFT00000014457; ENSCAFP00000013370; ENSCAFG00000009083
GeneIDi100856240
KEGGicfa:100856240

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85455
VGNCiVGNC:39967, DISP2

Phylogenomic databases

eggNOGiKOG3664, Eukaryota
GeneTreeiENSGT00940000159551
HOGENOMiCLU_004076_1_1_1
InParanoidiF1PRY8
OMAiLMGFEPR
OrthoDBi1156918at2759
TreeFamiTF324144

Enzyme and pathway databases

ReactomeiR-CFA-5362798, Release of Hh-Np from the secreting cell

Gene expression databases

BgeeiENSCAFG00000009083, Expressed in large intestine and 16 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000731, SSD
PfamiView protein in Pfam
PF12349, Sterol-sensing, 1 hit
PROSITEiView protein in PROSITE
PS50156, SSD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PRY8_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PRY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: June 2, 2021
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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