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Entry version 47 (16 Jan 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-CFA-2467813 Separation of Sister Chromatids
R-CFA-2500257 Resolution of Sister Chromatid Cohesion
R-CFA-5663220 RHO GTPases Activate Formins
R-CFA-68877 Mitotic Prometaphase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1PRS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000012593 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9615.ENSCAFP00000018561

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1PRS3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini652 – 789CENP-F_leu_zipInterPro annotationAdd BLAST138
Domaini890 – 1029CENP-F_leu_zipInterPro annotationAdd BLAST140
Domaini1072 – 1211CENP-F_leu_zipInterPro annotationAdd BLAST140
Domaini1727 – 1771CENP-F_C_Rb_bdgInterPro annotationAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili44 – 78Sequence analysisAdd BLAST35
Coiled coili307 – 370Sequence analysisAdd BLAST64
Coiled coili549 – 618Sequence analysisAdd BLAST70
Coiled coili649 – 669Sequence analysisAdd BLAST21
Coiled coili698 – 718Sequence analysisAdd BLAST21
Coiled coili726 – 756Sequence analysisAdd BLAST31
Coiled coili775 – 844Sequence analysisAdd BLAST70
Coiled coili866 – 893Sequence analysisAdd BLAST28
Coiled coili901 – 1037Sequence analysisAdd BLAST137
Coiled coili1052 – 1075Sequence analysisAdd BLAST24
Coiled coili1083 – 1110Sequence analysisAdd BLAST28
Coiled coili1118 – 1289Sequence analysisAdd BLAST172
Coiled coili1307 – 1362Sequence analysisAdd BLAST56
Coiled coili1377 – 1475Sequence analysisAdd BLAST99
Coiled coili1477 – 1584Sequence analysisAdd BLAST108
Coiled coili1592 – 1622Sequence analysisAdd BLAST31
Coiled coili1630 – 1650Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJF Eukaryota
ENOG410XS5F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111187

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1PRS3

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQDEIMS

TreeFam database of animal gene trees

More...
TreeFami
TF101133

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018302 CenpF/LEK1_Rb-prot-bd
IPR019513 Centromere_CenpF_leu-rich_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10490 CENP-F_C_Rb_bdg, 1 hit
PF10473 CENP-F_leu_zip, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1PRS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DLETGNLPQD AQSQELSSPK DCDIGTEEKY ISVLHELSTS QNDNAHLQCS
60 70 80 90 100
LQAAMSKLSE LEKMCEMLQV EKLELMSELN DSRSECITAT SKMTEVMEKL
110 120 130 140 150
VNEVKILNDE SGLLQGELEK EMAEGESGEQ QNEQKGASLN PLDDRNCYEH
160 170 180 190 200
LTLSNKEVQM HFAELQEKFL SLQSEHKILH DQHCQVSSKM SELQSYVDAL
210 220 230 240 250
KAENSMLSTS LRNFQGDLVK EEMPEPQAGH FLSLSFSCVT DSPSLTSLGE
260 270 280 290 300
SSFCKDLLDQ TGEASLLNNL DGTIAANQSN LEEGSCCSPE EENLTKREIL
310 320 330 340 350
SAPGRSVEDL ETQCQMYLQS LKKLEDKIES QEILKNKEIK ELEQLLSSER
360 370 380 390 400
EELDSLRKQY LSENEQWQQK LTSVTMEMES KLAAEKKQTE HLSFELEVAR
410 420 430 440 450
LQLQGLDLSS RSLLGTDLED VSMGGNTSCD VKESEEYTLE TKERTPKRDI
460 470 480 490 500
HQICEEGVQQ DLNLEMEKIT KTSPVRFTGE WSSKQSPETS YETLVQDKTQ
510 520 530 540 550
GCLDISELSL SGPNALVPID FLETQVTIEN LQLQVKESSN ENLRLLHVIE
560 570 580 590 600
ERDKKIESLL DEIRDLDSKL GLQEAQITTK MEACVELEKI VEELKKEKSN
610 620 630 640 650
LSERLESSSR DNQELHQRTE SLEGFNSHLE IGADKLSHAV IEDNVAKVND
660 670 680 690 700
NWRERFLDME NELKRIKSEK GSIEHHALSV EAELETVQTE KLYLVKDNEN
710 720 730 740 750
KQKAITCLEE ELSVVTSERN QLHGQLDTLS KEKKELDLMS EKMKQKIQEL
760 770 780 790 800
ESREDECLHP SDMAGAEVKD KMQLVQRLSS DVTQLLEDNT RLQEQLQSLE
810 820 830 840 850
KDSQALSLVK SELEIQIEQL NKEKESLSRE SESLQARLHE SEHEKLTVAK
860 870 880 890 900
ALEGALMEKG EVAVRLSSTQ EEVHQLRKGI EKLRIRIEAD EKKQLHVLEK
910 920 930 940 950
LRESERKADA LQDKIENLER ELQMSEENQE LVILDAENSK AEVETLKTQM
960 970 980 990 1000
ELTTKSLKDL ESDLVTVRFE KENLIKQLQD KQGQVSELDT LLSSFKGQLE
1010 1020 1030 1040 1050
EKEREKIEMK EESRAALEML RTQLKELNEE IAALCHDQEI QKVKEQSLDP
1060 1070 1080 1090 1100
LVQEIHQLRN NTEKLKARLE ADEKEQLRVL GKLKETEHQA SLLKDRVESL
1110 1120 1130 1140 1150
ERELEISGKN QECVVLEAEN SKAEVGTLKV KIEEMAQNLR DLELDLVHIR
1160 1170 1180 1190 1200
SEKENMIKEL QKEQERVSEL ELLNSSFENL LQEKEQEKVQ MSEESKTAVG
1210 1220 1230 1240 1250
MLQTQLKELN EEMAALCHDQ DTWKAQEQNL RSQVDALEHE KAQLLQGLEE
1260 1270 1280 1290 1300
AKNNYINVQS SANSLHQQVE DDKQKLKKKD EEINMLKSQI HDREQLASKL
1310 1320 1330 1340 1350
SQVEGEQQLW KKQKVELENL MVELEQKIQV LQSKNDTLQD TLEALQKSHK
1360 1370 1380 1390 1400
DLEKELELTK MENVSFIEKV NTMTGKETEL QREMHEMAQK TSELKEEFIG
1410 1420 1430 1440 1450
EKNRLTEELN TMSEEINSSR GQLKELMLEN SELKNSLDCI HKDQMEKEEK
1460 1470 1480 1490 1500
VREEIANYQL QLQEAEKKHQ ALLLDTNKQY EMEIQTYQEK LSSKEECLSS
1510 1520 1530 1540 1550
QKAEIDLLKS SKEELNNSLK ATTQLLEELK KTKADHVKYT NQLKKENERA
1560 1570 1580 1590 1600
QGKIKLLIKS CKQLEEEKEM LQKELSHLEA TQENQKTGTV VDSNAEELMA
1610 1620 1630 1640 1650
EMKELKETLE EKTKEADEYL DKYCSLLISH EKLEKAKEML ETQVARLSSR
1660 1670 1680 1690 1700
SKPHLQNSPL LNSVVPEASL APSATEKKLS SGQNTASGKR QRSTGIREDG
1710 1720 1730 1740 1750
GGTASSTPET FSKKSRKAVR SGIHPAEEAK DTEFEPEGLP EVVKKGFADI
1760 1770 1780 1790 1800
PTGKTSPYVL RRTTMPTRTS PRLAAQKLAL SPLSLNKENH AETSQPTAGG
1810 1820 1830 1840 1850
SRSQKVKVAQ QSPADSSTAF REPTTRVSSL PERSSADSPR EGLRAKRSRL
1860
APSPEAVPES KSSENCRVQ
Length:1,869
Mass (Da):213,082
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3B1BD4687C68410
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03005110 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000020009; ENSCAFP00000018561; ENSCAFG00000012593

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005110 Genomic DNA No translation available.

3D structure databases

SMRiF1PRS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018561

Proteomic databases

PaxDbiF1PRS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000020009; ENSCAFP00000018561; ENSCAFG00000012593

Phylogenomic databases

eggNOGiENOG410IGJF Eukaryota
ENOG410XS5F LUCA
GeneTreeiENSGT00730000111187
InParanoidiF1PRS3
OMAiVQDEIMS
TreeFamiTF101133

Enzyme and pathway databases

ReactomeiR-CFA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-CFA-2467813 Separation of Sister Chromatids
R-CFA-2500257 Resolution of Sister Chromatid Cohesion
R-CFA-5663220 RHO GTPases Activate Formins
R-CFA-68877 Mitotic Prometaphase

Gene expression databases

BgeeiENSCAFG00000012593 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR018302 CenpF/LEK1_Rb-prot-bd
IPR019513 Centromere_CenpF_leu-rich_rpt
PfamiView protein in Pfam
PF10490 CENP-F_C_Rb_bdg, 1 hit
PF10473 CENP-F_leu_zip, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PRS3_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PRS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: January 16, 2019
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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