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Entry version 58 (08 May 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Collagen type VI alpha 3 chain

Gene

COL6A3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • growth plate cartilage chondrocyte morphogenesis Source: GO_Central

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-1442490 Collagen degradation
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-186797 Signaling by PDGF
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-3000178 ECM proteoglycans
R-CFA-419037 NCAM1 interactions
R-CFA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type VI alpha 3 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL6A3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:39481 COL6A3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500326916726 – 3161Sequence analysisAdd BLAST3136

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1PR31

PRoteomics IDEntifications database

More...
PRIDEi
F1PR31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000012226 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000018017

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1PR31

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 213VWFAInterPro annotationAdd BLAST175
Domaini242 – 419VWFAInterPro annotationAdd BLAST178
Domaini445 – 620VWFAInterPro annotationAdd BLAST176
Domaini639 – 816VWFAInterPro annotationAdd BLAST178
Domaini837 – 1009VWFAInterPro annotationAdd BLAST173
Domaini1029 – 1205VWFAInterPro annotationAdd BLAST177
Domaini1233 – 1404VWFAInterPro annotationAdd BLAST172
Domaini1436 – 1609VWFAInterPro annotationAdd BLAST174
Domaini1639 – 1812VWFAInterPro annotationAdd BLAST174
Domaini1838 – 2024VWFAInterPro annotationAdd BLAST187
Domaini2402 – 2581VWFAInterPro annotationAdd BLAST180
Domaini2619 – 2815VWFAInterPro annotationAdd BLAST197
Domaini2989 – 3080Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini3109 – 3159BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG41103QR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156462

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1PR31

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFYFNSY

TreeFam database of animal gene trees

More...
TreeFami
TF337483

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit
cd00109 KU, 1 hit
cd01481 vWA_collagen_alpha3-VI-like, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.40.50.410, 12 hits
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR041900 vWA_collagen_alpha3-VI-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 2 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 12 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 12 hits
SSF57362 SSF57362, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 1 hit
PS50234 VWFA, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1PR31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKHRHLPLV AIFCLFLSGF SLTRAQQQQA DVKNGAAADI IFLVDSSWSI
60 70 80 90 100
GKEHFQLVRE FLYDVIKSLA VGDSDFRFAL VQFNGNPHTE FLLNTYRTKQ
110 120 130 140 150
EVLSHISNMS YIGGSNETGK GLEYVMQHHL TEAAGSRAGD GVPQVIVVLT
160 170 180 190 200
HGHSDDRLAL PSAELKSADA NVFAIGVEDA DEGALKEIAS EPPNMHVFNL
210 220 230 240 250
ENFTSLHDIV GNLVSCVQSS VAPEGAGGTE TLKDITAQDS ADIIFLIDGS
260 270 280 290 300
NNTGSAHFAV IRDFLVNLLE RLSVGAQQIR VGVVQYSDEP RTVFSLDTYS
310 320 330 340 350
TKAQVLDAVK ALAFTGGELA NVGLALDFVV ENHFTRAGGS RVEEGVPQVL
360 370 380 390 400
VLISAGPSSD EIRDGVVALK QASVFSFGLG AQAASRAELQ HIATNDNLVF
410 420 430 440 450
TVPEFRSFGD LQEQLLPYIV GVAQRHIVLQ PPTIVTEVIE VNKRDIVFLV
460 470 480 490 500
DGSSALGLAN FNAIRDFIAK VIQRLEIGQD LIQVAVAQYA DTVRPEFYFN
510 520 530 540 550
SYPNKREVIA AVRRMKPMEG SVLYTGSALD FARDNLFTSS AGYRAAEGVP
560 570 580 590 600
KLLVLITGGK SLDEISQPAQ ELKRNSIMSF AVGSKAADQA ELEEIAFDSS
610 620 630 640 650
LVFIPTEFRA APLQGLLPGL LAPLRTLSGT SEVHANRRDI IFLLDGSFNV
660 670 680 690 700
GKANFPYVRD FVMNVVNNLD VGSDNIRVGL VQFSDTPVTE FSLNTYQTKS
710 720 730 740 750
DLLAHLRQLQ LKGGSGLNTG SALSYVHANH FTEAGGSRIR EHVPQLLLLL
760 770 780 790 800
TAGRSEDAYL PAANALARAG VLTFCVGANQ ANRAELEQIA FNPSLVYLMD
810 820 830 840 850
DFSSLPALPQ QLIQPLTTYV SGGVEEVPLA QPESKRDILF LFDGSANLVG
860 870 880 890 900
QFPAVRDFLY KVIDELDVKP EGTRVAVAQY SDDVRVESRF DEHQNKPEIL
910 920 930 940 950
NLVKRMKIKT GKTLNLGYAL DYARRYIFVK SAGSRIEDGV LQFLVLLVAG
960 970 980 990 1000
RSSDRLDTPA LNLKQSGVVT FILQAKNADP TELELMVPSP VFILAAESLP
1010 1020 1030 1040 1050
KIGDLQPQIV NLLKSVQNGA PAPVSGEKDV VFLIDGSEGV RSGFPLLKEF
1060 1070 1080 1090 1100
VQRVVESLDV GPDRVRVAVV QYSDRTRPEF YLNSYMDQQS VVSAIRRLTI
1110 1120 1130 1140 1150
LGGPTPNTGA ALDFVLRNIL ISSAGSRIAE GVPQLLIVLT ADRSGDDVRG
1160 1170 1180 1190 1200
PSVVLKRGGA VPIGIGIGNA DITEMQTISF IPDFAVAIPT FRQLGTIQQV
1210 1220 1230 1240 1250
VSDRVIQLSR EELSRLQPVL LPPTSPGVGS KKDVVFLIDG SQNASPEFQY
1260 1270 1280 1290 1300
IRTLIERLVD YLDVGFDTTR VAVIQFSEDP RVEFLLNAHS SKDEVQNAVR
1310 1320 1330 1340 1350
RLRPKGGRQI NIGSALEYVS RNIFKRPLGS RIEEGVPQFL VLISSGKSDD
1360 1370 1380 1390 1400
EVDDSAAELK QFGVAPFTIA RDADQEQLVK ISLSPEYVFS VNTFRELPSL
1410 1420 1430 1440 1450
EQKLLTPITT LTSEQIQQIL ASTRYPSPGI ESDAADIIFL IDSSDSVKPD
1460 1470 1480 1490 1500
DIAYIRDFVI KIVRRLNIGP NKVRIGAVQF SNEVFPVFYL KTHKSQASVI
1510 1520 1530 1540 1550
NALRQLRHRG GSPLNTGKAL EFVARNLFVK SAGSRIEDGV PQHLVLFLGG
1560 1570 1580 1590 1600
KSQDDTSRFS QVISSSGIVS LGVGNRNIDR AELQTITNNP RLVFTVREFR
1610 1620 1630 1640 1650
ELPNIEDRVM HAFGPSGVTP APPGVDTPSP SRPEKKKADV VFLLDGSINF
1660 1670 1680 1690 1700
RRDSFQEVLR FVSEIVDTLY EGGDSIQVGL VQYNSDPTDE FFLKDFSTKQ
1710 1720 1730 1740 1750
QIIDAINKVV YKGGRHANTK VGIEHLRLNH FVPEAGSRLD QRVPQIAFVI
1760 1770 1780 1790 1800
TGGKSVEDAQ EASLALTQKG VKVFAVGVKN IDSEEVGKIA SNSATAFRVG
1810 1820 1830 1840 1850
NVQELSELSE QVLETLHDAM HETLCPGVTD ISKVCNLDVI LGFDGSRDQN
1860 1870 1880 1890 1900
VFVTQKGLES KMDAILNRIS QMQRISCSGS QMPTVRVSVV ANTPSGPVEA
1910 1920 1930 1940 1950
FDFAEYQPEL FEKFRNMRNQ HPYVLTADTL KVYQNKFRQS SADNVKVVIH
1960 1970 1980 1990 2000
FTDGVDGNLA DLQKASEELR QEGVQALILV GLERVANLEQ LMQLEFGRGF
2010 2020 2030 2040 2050
LYNRPLRLNL LDLDYELAEQ LDNIAEKACC GVPCKCSGQR GDRGPIGSIG
2060 2070 2080 2090 2100
PKGIPGEDGY RGYPGDEGGP GERGPPGVNG TQGFQGCPGQ RGIKGSRGFP
2110 2120 2130 2140 2150
GEKGELGEIG LDGLDGEDGD KGLPGSSGEK GNPGRRGDKG PKGVKGERGD
2160 2170 2180 2190 2200
VGFRGDPGDS GRDSQQRGPK GETGDIGPMG LPGRDGVSGS PGDPGKEGGF
2210 2220 2230 2240 2250
GRRGPAGTKG NKGGPGQPGS AGEQGARGAQ GPPGPTGPPG LIGEQGISGP
2260 2270 2280 2290 2300
RGGGGTTGVP GERGRIGPLG RKGEPGEPGQ KGGIGSRGPR GETGDDGRDG
2310 2320 2330 2340 2350
VGSEGRKGKK GERGFPGYPG PKGVPGEPGT GGPPGPKGIR GRRGNSGPPG
2360 2370 2380 2390 2400
AIGQKGDPGY PGPSGPKGNR GDSMDQCALV QSIKDKCPLP TGPLECPVFP
2410 2420 2430 2440 2450
TELAFALDTS EGVTQDTFSR MRDVVLKLVG DLTIAESNCP RGARVAVVTY
2460 2470 2480 2490 2500
NNEVTTEIRF ADSKKKSVLL DKIKNLQVAL TSKQQSLETA MSFVARNTFK
2510 2520 2530 2540 2550
RVRNGFLMRK VAVFFSNKPT RASPQLREAV LKLSDAGITP LFLTSQEDRQ
2560 2570 2580 2590 2600
LVNALQINNT AVGHALVLPA RRDLTDFLKN VLTCHVCLDI CNIDPACGFG
2610 2620 2630 2640 2650
NWKPSFRDRR AAGSDVDIDM AFILDSSEST SLFQFNEMKK YIGYLVRQLD
2660 2670 2680 2690 2700
ISPDPKASQH FARVAVVQHA PYESLGNPSL PPVKVEFSLT DYGSKEKLVD
2710 2720 2730 2740 2750
FLSRRMTQLE GTRDLGSAIE YTIENVFESA PNPRDLKIIV LMLTGEVEKE
2760 2770 2780 2790 2800
QLEEAHRVIL QAKCKGYFFV ILGIGRKVNV KEVYSFASEP NDVFFKLLDK
2810 2820 2830 2840 2850
PTELNEEPLM RFGRLLPSFV GSENAFYLSP DIRKQCDWFQ GDQLTKNPVK
2860 2870 2880 2890 2900
FGHKQLNTPN NATSSPTSKP VTTAKPMTTT EPVTTTTKPV TVPAPPKPAA
2910 2920 2930 2940 2950
AKPMAAKPVA TKPEAAKPEA AKPEATKTAT VKPAVAVKPA AAKPVAAKPA
2960 2970 2980 2990 3000
AVRPPVAARP VAAKPEAPKP QGAKPAATKP ATSKPVAKAT REVRVSDITE
3010 3020 3030 3040 3050
NSAKLHWERP EPPSPYFYDL TVTSAHDQSL VLRQNLSATE RAIGGLLAGH
3060 3070 3080 3090 3100
TYHVAVVCYL RAQARAVYQG SFSTKKAQPP PSQARLASSS TVNLMVSTEP
3110 3120 3130 3140 3150
LAGGETDICK LPKEEGTCRK FMLKWYYDVE TKSCMRFWYG GCSGNENRFD
3160
SQKECETVCT P
Length:3,161
Mass (Da):341,869
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F9A2DC6BBBF6D66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1PR39F1PR39_CANLF
Collagen type VI alpha 3 chain
COL6A3
2,986Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V9A6F6V9A6_CANLF
Collagen type VI alpha 3 chain
COL6A3
2,671Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03014481 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000019420; ENSCAFP00000018017; ENSCAFG00000012226

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03014481 Genomic DNA No translation available.

3D structure databases

SMRiF1PR31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000018017

Proteomic databases

PaxDbiF1PR31
PRIDEiF1PR31

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000019420; ENSCAFP00000018017; ENSCAFG00000012226

Organism-specific databases

VGNCiVGNC:39481 COL6A3

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG41103QR LUCA
GeneTreeiENSGT00940000156462
InParanoidiF1PR31
OMAiEFYFNSY
TreeFamiTF337483

Enzyme and pathway databases

ReactomeiR-CFA-1442490 Collagen degradation
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-186797 Signaling by PDGF
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-3000178 ECM proteoglycans
R-CFA-419037 NCAM1 interactions
R-CFA-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSCAFG00000012226 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd00063 FN3, 1 hit
cd00109 KU, 1 hit
cd01481 vWA_collagen_alpha3-VI-like, 3 hits
Gene3Di2.60.40.10, 1 hit
3.40.50.410, 12 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR041900 vWA_collagen_alpha3-VI-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 12 hits
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 12 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 12 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 1 hit
PS50234 VWFA, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PR31_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PR31
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: May 8, 2019
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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