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Protein
Submitted name:

Receptor interacting serine/threonine kinase 1

Gene

RIPK1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-3371378 Regulation by c-FLIP
R-CFA-5213460 RIPK1-mediated regulated necrosis
R-CFA-5218900 CASP8 activity is inhibited
R-CFA-5357786 TNFR1-induced proapoptotic signaling
R-CFA-5357905 Regulation of TNFR1 signaling
R-CFA-5357956 TNFR1-induced NFkappaB signaling pathway
R-CFA-5689880 Ub-specific processing proteases
R-CFA-5689896 Ovarian tumor domain proteases
R-CFA-69416 Dimerization of procaspase-8
R-CFA-75893 TNF signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor interacting serine/threonine kinase 1Imported
Gene namesi
Name:RIPK1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 35

Organism-specific databases

VGNCiVGNC:45594 RIPK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1PQX4

Expressioni

Gene expression databases

BgeeiENSCAFG00000009321

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013721

Structurei

3D structure databases

ProteinModelPortaliF1PQX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 285Protein kinaseInterPro annotationAdd BLAST273
Domaini577 – 663DeathInterPro annotationAdd BLAST87

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00550000074536
InParanoidiF1PQX4
KOiK02861
OMAiVMEYMEK
OrthoDBiEOG091G0479
TreeFamiTF106506

Family and domain databases

CDDicd08777 Death_RIP1, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR025735 RHIM_dom
IPR037934 RIP1_Death
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF12721 RHIM, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

F1PQX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDDIKMKS SDFLEKEHLD SGGFGKVSLC LHRSHGLVIL KKVYTGPKRT
60 70 80 90 100
EYNESLLEEG RMMHRLRHRR VVKLLGVILE EGNYSLVMEY MEKGNLMHVL
110 120 130 140 150
KAEVSIPLSV KGRIIMETIE GMCYLHGEGV IHKDLKPENI LVDDDFHIKI
160 170 180 190 200
ADLGVASFKT WSKLTKEEIN EQRKLNSVSK KNGGTLCYMA PEHLNDINAK
210 220 230 240 250
PSEKSDVYSF GIVLWAIFAN KEPYENAICE QQLILCIKSG NRPDVEDIIE
260 270 280 290 300
YCPEEIISIM KQCWEAKPEI RPTFAGIEEK FRPFYEDQLE ENVEEDVTSL
310 320 330 340 350
KKEYPDPAQN SVVKRMQSLQ IDCVATPPSR SNSAPEQPSS LHSSQGLGIG
360 370 380 390 400
PVEESWFAPS LENQQDENQL SLQSKLQEEA NYHLYGSRMD RQTKPLRQSV
410 420 430 440 450
AYNREEERRR RVSHDPFAQQ RPYENIQNPG VKGLPYSIAT SPGNAVHQPK
460 470 480 490 500
GLTSQPPVRY WNNELYSPFN FRTRPLALGT TGSRVWYQPN PSHIPSVNKT
510 520 530 540 550
PVPETNLLGN TPTIPFSSFP SRDESVKCTI YNSSGIQVGE HNYMEVGGMS
560 570 580 590 600
SALLDMNVKE EPAYKYQDIF DNVTSLTDKH LDPVRENLGK QWKNCARKLG
610 620 630 640 650
FTEPQIDEID HDYERDGLKE KVYQMLQKWL MREGNKGATV GKLAYALYQC
660
SRIDLLNYLI HISQN
Length:665
Mass (Da):75,920
Last modified:October 31, 2012 - v2
Checksum:iC826BEB52F0D4B72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03017475 Genomic DNA No translation available.
RefSeqiXP_005640038.1, XM_005639981.2

Genome annotation databases

EnsembliENSCAFT00000014829; ENSCAFP00000013721; ENSCAFG00000009321
GeneIDi102152063
KEGGicfa:102152063

Similar proteinsi

Entry informationi

Entry nameiF1PQX4_CANLF
AccessioniPrimary (citable) accession number: F1PQX4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: June 20, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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