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Entry version 54 (12 Aug 2020)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

TSC22 domain family member 1

Gene

TSC22D1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TSC22 domain family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSC22D1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:47892, TSC22D1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1PJA5

PRoteomics IDEntifications database

More...
PRIDEi
F1PJA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000004584, Expressed in brain and 51 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000006854

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1PJA5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 119DisorderedSequence analysisAdd BLAST119
Regioni134 – 301DisorderedSequence analysisAdd BLAST168
Regioni462 – 494DisorderedSequence analysisAdd BLAST33
Regioni602 – 683DisorderedSequence analysisAdd BLAST82
Regioni704 – 723DisorderedSequence analysisAdd BLAST20
Regioni1038 – 1074DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili997 – 1031Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 68PolarSequence analysisAdd BLAST16
Compositional biasi69 – 93Pro-richSequence analysisAdd BLAST25
Compositional biasi94 – 108PolarSequence analysisAdd BLAST15
Compositional biasi181 – 197PolarSequence analysisAdd BLAST17
Compositional biasi225 – 249BasicSequence analysisAdd BLAST25
Compositional biasi283 – 301PolarSequence analysisAdd BLAST19
Compositional biasi462 – 491PolarSequence analysisAdd BLAST30
Compositional biasi607 – 621Pro-richSequence analysisAdd BLAST15
Compositional biasi625 – 683PolarSequence analysisAdd BLAST59

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4797, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010450_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1PJA5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIVNPQT

Database of Orthologous Groups

More...
OrthoDBi
1602203at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000580, TSC-22_Dip_Bun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01166, TSC22, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01289, TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F1PJA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHQPPESTAA AAAAAADISA RKMAHPAMFP RRGSGGGGGG GGGGGGASAL
60 70 80 90 100
SAAGTGVGSS VTSSEDFPPP SLLQPPPPAA SSTSGPQPPP PQSLNLLSQA
110 120 130 140 150
QLQAQPLAPG GTQMKKKSGF QITSVTPAQI SASISSNNSI AEDTESYDDL
160 170 180 190 200
DESHTEDLSS SEILDVSLSR ATDLGEPERS SSEETLNNFQ EAETPGAVSP
210 220 230 240 250
NQPHLPQPHL PHLPPQNVVI NGNAHPHHLH HHHHIHHGHH LHHGHHHPSH
260 270 280 290 300
AGVASPPIPG GPPSSPGSRK LSAPGSADSV APAAPTSAVS SGGSPASVMT
310 320 330 340 350
NIRAPSTTGS IGISSVTGAT TVNNVNITAV GTFNPSVTSS MLSNASINAS
360 370 380 390 400
NISSAASASV GPGVSSGVNV NILSGMGNGS ISSSAVVNSA PNAAAGMTVG
410 420 430 440 450
SVSSQQQPPT VNTSRFRVVK LDSSSEPFKK GRWTCTEFYE KENAAPAAEG
460 470 480 490 500
VAMNKVVETV KQNPEVTSER ESTSGSSVSS SVSTLSHYTE SVGSGEMGAP
510 520 530 540 550
TVVVQQQQQQ QPTLQGMALQ QMDFSSSGPQ SISAVSIPQS ISQSQITQVQ
560 570 580 590 600
LQSQELSYQK PGLQPVPLQA TLSTATGIQP SPVNVVGVTS ALGQQPSISS
610 620 630 640 650
LAQPQLPYSQ PAPPVQAPLP GAPPQQLQYG QQQPTVSAQM VPGHGKPVTQ
660 670 680 690 700
NPTSEYVQQQ PPPPMLQTAV SSGQPSAASV GAGSTVIPTA QPQSIQLPVQ
710 720 730 740 750
PTAIQAQPAG ASGQPVGQAQ TAGSVVPTGG QIANIGQQAN IATAVQQPST
760 770 780 790 800
QVTPSVIQQG APPSSQIVSP AQTAIIHQGV QTSASSLPQQ LVLAPQSTLL
810 820 830 840 850
TVPPQPQGVE SVAQVSQQLP AVSPLPSASS ISVTNQVSSA GPSGMPSAPT
860 870 880 890 900
NLVPPQNIAQ TPATQNGNLV QSVSQPPLIA TNINLPLAQQ IPLSSTQFSA
910 920 930 940 950
QSLAQAIGSQ IEDARRPAEP SLVGLPQTIS GDSGGMSAVS DGSSSSLAAS
960 970 980 990 1000
ASLFPLKVLP LTTPLVDGED ESSSGASVVA IDNKIEQAMD LVKSHLMYAV
1010 1020 1030 1040 1050
REEVEVLKEQ IKELIEKNSQ LEQENNLLKT LASPEQLAQF QAQLQTGSPP
1060 1070
ATTQPQGTTQ PPAQPASQGS GPTA
Length:1,074
Mass (Da):108,840
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FCC3302FB354DFC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9P2M0J9P2M0_CANLF
TSC22 domain family member 1
TSC22D1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4CQI7A0A5F4CQI7_CANLF
TSC22 domain family member 1
TSC22D1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9NZ78J9NZ78_CANLF
TSC22 domain family member 1
TSC22D1
1,029Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4C5K9A0A5F4C5K9_CANLF
TSC22 domain family member 1
TSC22D1
985Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4D7Q0A0A5F4D7Q0_CANLF
TSC22 domain family member 1
TSC22D1
1,052Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03013153 Genomic DNA No translation available.
AAEX03013154 Genomic DNA No translation available.
AAEX03013155 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_534128.3, XM_534128.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000007397; ENSCAFP00000006854; ENSCAFG00000004584

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
476927

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013153 Genomic DNA No translation available.
AAEX03013154 Genomic DNA No translation available.
AAEX03013155 Genomic DNA No translation available.
RefSeqiXP_534128.3, XM_534128.5

3D structure databases

SMRiF1PJA5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000006854

Proteomic databases

PaxDbiF1PJA5
PRIDEiF1PJA5

Genome annotation databases

EnsembliENSCAFT00000007397; ENSCAFP00000006854; ENSCAFG00000004584
GeneIDi476927

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8848
VGNCiVGNC:47892, TSC22D1

Phylogenomic databases

eggNOGiKOG4797, Eukaryota
GeneTreeiENSGT00940000159144
HOGENOMiCLU_010450_0_0_1
InParanoidiF1PJA5
OMAiSIVNPQT
OrthoDBi1602203at2759
TreeFamiTF318837

Gene expression databases

BgeeiENSCAFG00000004584, Expressed in brain and 51 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000580, TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166, TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289, TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PJA5_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PJA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: August 12, 2020
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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