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Entry version 68 (07 Oct 2020)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Tenascin C

Gene

TNC

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tenascin CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:47646, TNC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502380712423 – 2201Sequence analysisAdd BLAST2179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 200PROSITE-ProRule annotation
Disulfide bondi207 ↔ 216PROSITE-ProRule annotation
Disulfide bondi284 ↔ 294PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi377 ↔ 387PROSITE-ProRule annotation
Disulfide bondi394 ↔ 403PROSITE-ProRule annotation
Disulfide bondi470 ↔ 480PROSITE-ProRule annotation
Disulfide bondi487 ↔ 496PROSITE-ProRule annotation
Disulfide bondi563 ↔ 573PROSITE-ProRule annotation
Disulfide bondi580 ↔ 589PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F1PF31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000003426, Expressed in cartilage tissue and 48 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini186 – 217EGF-likeInterPro annotationAdd BLAST32
Domaini280 – 311EGF-likeInterPro annotationAdd BLAST32
Domaini373 – 404EGF-likeInterPro annotationAdd BLAST32
Domaini466 – 497EGF-likeInterPro annotationAdd BLAST32
Domaini559 – 590EGF-likeInterPro annotationAdd BLAST32
Domaini625 – 715Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini716 – 804Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini805 – 894Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini895 – 987Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini988 – 1077Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1078 – 1165Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1167 – 1256Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1258 – 1347Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1349 – 1438Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1440 – 1528Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1531 – 1621Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1622 – 1711Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1712 – 1801Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1802 – 1888Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1889 – 1977Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1975 – 2190Fibrinogen C-terminalInterPro annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 90DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 139Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155188

KEGG Orthology (KO)

More...
KOi
K06252

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 15 hits
cd00087, FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR041161, EGF_Tenascin
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR033078, TNC

The PANTHER Classification System

More...
PANTHERi
PTHR46708:SF1, PTHR46708:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974, EGF_2, 3 hits
PF18720, EGF_Tenascin, 9 hits
PF00147, Fibrinogen_C, 1 hit
PF00041, fn3, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 14 hits
SM00186, FBG, 1 hit
SM00060, FN3, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 12 hits
SSF56496, SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS51406, FIBRINOGEN_C_2, 1 hit
PS50853, FN3, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

F1PF31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAATRLLAG ILLALLTLTT EGGVLKKVIR HKRESGVNVT LSEEHQPVVF
60 70 80 90 100
NHVYNIKLPV GSQCSVDLES ASGEKELAPP SEPSESFQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TTGAGCCLQP
160 170 180 190 200
AEGRLDTRPL CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGQC
210 220 230 240 250
LDGQCVCDEG FTGEDCSQLA CPSDCNDQGK CVSGVCVCFE GYTGADCGDE
260 270 280 290 300
VCPVPCNEEH GRCVEGRCVC QDGFAGEDCS EPLCLNSCHN RGRCVENECV
310 320 330 340 350
CDEGFTGEDC SELICPNDCF DRGRCVNGTC YCEQGFSGED CGQLSCPNAC
360 370 380 390 400
TGRGRCEQGQ CVCEPGFAGP DCSDRSCPND CHHRGRCVHG RCECDAGFGG
410 420 430 440 450
PDCGQLQCPR GCSGHGHCVN GQCVCDEGHT GEDCGQLRCP NDCHSRGRCV
460 470 480 490 500
QGQCVCEPGF QGYDCSDMSC PNDCHQHGRC VNGMCVCDDG YTGEDCRDLR
510 520 530 540 550
CPRDCSDRGR CVAGRCECEH GFTGPDCADL ACPADCHGQG RCVNGQCVCH
560 570 580 590 600
EGFTGATCQE RRCPGDCQGR GRCEDGRCTC QEGFTGPDCG QRSCPNGCSG
610 620 630 640 650
WGQCVEGRCV CSEGHAGEDC SQVSPPKDLI VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLVTYTPTH EDGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKK
710 720 730 740 750
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETTYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT
810 820 830 840 850
TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELSYGIK DVPGDRTTID
860 870 880 890 900
LTHDENQYSI GSLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR
910 920 930 940 950
RVSQTDNSIT LEWRNGKAAV DSYRIKYAPI SGGDHAEVEV PRSPQATTKT
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKA DKESDPATIN AATDLDAPKD LRVSETTDTH
1010 1020 1030 1040 1050
LTLLWRKPSA KFDHYRLNYS LPSGQPVEVK LPRDTTSYDL RGLEPGKGYS
1060 1070 1080 1090 1100
ILLTAEKGRH KSKPARLNAS TDHAPELENL TVTEAGWDGL RLNWTAADQA
1110 1120 1130 1140 1150
YEHFVIQVQE ADTMEAPQNL TVPGSLRAVE VPGLKAATPY RVTIYGVIRG
1160 1170 1180 1190 1200
YRTPVLSAEA STGETPNLGE VMVSEVGWNA LKLNWTAPEG AYEQFFIQVQ
1210 1220 1230 1240 1250
ETDSVEAAQN LTVPGGLRSV DLPGLKAATH YSVTIRGLTR DFSTTPLSVE
1260 1270 1280 1290 1300
VLTEEVPDLG NLTVPEVRWD GLTLDWTAPD GFYEQFVIEI QEADQAKEAH
1310 1320 1330 1340 1350
SLTVPGNLRS VEFPGLRPGT PYTITLHGEV GGHSTRPLVV EAITEELPQL
1360 1370 1380 1390 1400
GDLAVTEAGW DGLRLNWTAA DPAYEHFVIQ VQEANLVEAP QNLTVPGSLR
1410 1420 1430 1440 1450
AVEVPGLKAA TPYRVTIYGV IRGYRTPVLS AEASTATGPE VGNLTVSDIT
1460 1470 1480 1490 1500
PESFNLSWTA TDGAFETFTI EIVDSNRFLE TMEYNVSGTE RTAHISGLHP
1510 1520 1530 1540 1550
NNHFVIYLSG LAPSIRTKII SATATTEALP LLENLTISDI NPYGFTVSWM
1560 1570 1580 1590 1600
ASENAFDSFL VTVVDSGKLL DPQEFTLSGT QRKLELRGLI TGIGYEVMVS
1610 1620 1630 1640 1650
GFSQGHQTKP LRAEIVTEAE PEVDNLLVSD ATPDGFRLSW TADEGVFDSF
1660 1670 1680 1690 1700
VLKIRDTKKQ SEPLEITLLA PERTRDITGL REATEYEIEL YGISSGRRSQ
1710 1720 1730 1740 1750
PVSAIATTAM GSPKEISFSD ITEDSATVSW MAPSAQVESF RITYVPIAGG
1760 1770 1780 1790 1800
TSSVVNVDGT KTQTRLMKLL PGAEYLVSVI AMKGFEESEP VSGSFTTALD
1810 1820 1830 1840 1850
GPSGLVTANV TDTEALAMWQ PAIAPVDSYV ISYTGERVPE ITRTVSGNTV
1860 1870 1880 1890 1900
EYALTDLEPA TEYTLRIFAE KGPQKSSIIT TKFTTDLDSP RDLTATEVQS
1910 1920 1930 1940 1950
ETALLTWRPP RASVTGYLLV YESVDGTVKE VILGPETTSY NLAELSPSTH
1960 1970 1980 1990 2000
YTAKIQALNG PLRSKLVQTS FTTIGLLYPF PRDCSQAMLN GDTTSGLYTI
2010 2020 2030 2040 2050
YLNGDKAQAL EVYCDMTSDG GGWIVFLRRK NGREDFYRNW KAYAAGFGDR
2060 2070 2080 2090 2100
REEFWLGLDN LHKITAQGQY ELRVDLRDHG KTAYAVYDRF SVGDAKTRYK
2110 2120 2130 2140 2150
LKVEGYSGTA GDSMAYHNGR SFSTFDKDTD SAITNCALSY KGAFWYKNCH
2160 2170 2180 2190 2200
RVNLMGRYGD NNHSQGVNWF HWKGHEYSIQ FAEMKLRPSN FRNLEGRRKR

A
Length:2,201
Mass (Da):240,456
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF83E4B29D51C5788
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9NRP5J9NRP5_CANLF
Tenascin C
TNC
2,384Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4BYK6A0A5F4BYK6_CANLF
Tenascin C
TNC
2,110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4BZ85A0A5F4BZ85_CANLF
Tenascin C
TNC
2,019Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4CRD4A0A5F4CRD4_CANLF
Tenascin C
TNC
2,293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4CUE2A0A5F4CUE2_CANLF
Tenascin C
TNC
2,201Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4D590A0A5F4D590_CANLF
Tenascin C
TNC
2,293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4CEM1A0A5F4CEM1_CANLF
Tenascin C
TNC
2,293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4CR63A0A5F4CR63_CANLF
Tenascin C
TNC
2,292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4D081A0A5F4D081_CANLF
Tenascin C
TNC
2,111Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03008112 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001182078.1, NM_001195149.1
XP_005626481.1, XM_005626424.2
XP_013973140.1, XM_014117665.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000005551; ENSCAFP00000005140; ENSCAFG00000003426

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
481689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cfa:481689

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008112 Genomic DNA No translation available.
RefSeqiNP_001182078.1, NM_001195149.1
XP_005626481.1, XM_005626424.2
XP_013973140.1, XM_014117665.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiF1PF31

Genome annotation databases

EnsembliENSCAFT00000005551; ENSCAFP00000005140; ENSCAFG00000003426
GeneIDi481689
KEGGicfa:481689

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3371
VGNCiVGNC:47646, TNC

Phylogenomic databases

GeneTreeiENSGT00940000155188
KOiK06252

Gene expression databases

BgeeiENSCAFG00000003426, Expressed in cartilage tissue and 48 other tissues

Family and domain databases

CDDicd00063, FN3, 15 hits
cd00087, FReD, 1 hit
Gene3Di2.60.40.10, 15 hits
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR041161, EGF_Tenascin
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR033078, TNC
PANTHERiPTHR46708:SF1, PTHR46708:SF1, 1 hit
PfamiView protein in Pfam
PF07974, EGF_2, 3 hits
PF18720, EGF_Tenascin, 9 hits
PF00147, Fibrinogen_C, 1 hit
PF00041, fn3, 15 hits
SMARTiView protein in SMART
SM00181, EGF, 14 hits
SM00186, FBG, 1 hit
SM00060, FN3, 15 hits
SUPFAMiSSF49265, SSF49265, 12 hits
SSF56496, SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS51406, FIBRINOGEN_C_2, 1 hit
PS50853, FN3, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PF31_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PF31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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