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Protein

Tyrosine-protein kinase

Gene

ABL1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-CFA-375170 CDO in myogenesis
R-CFA-428890 Role of ABL in ROBO-SLIT signaling
R-CFA-5663213 RHO GTPases Activate WASPs and WAVEs
R-CFA-5685938 HDR through Single Strand Annealing (SSA)
R-CFA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CFA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:ABL1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:54912 ABL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1PEX6

Expressioni

Gene expression databases

BgeeiENSCAFG00000019938 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029535

Structurei

3D structure databases

ProteinModelPortaliF1PEX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 140SH3InterPro annotationAdd BLAST61
Domaini146 – 236SH2InterPro annotationAdd BLAST91
Domaini261 – 512Protein kinaseInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119011
InParanoidiF1PEX6
OMAiGAFRESG
OrthoDBiEOG091G0D46
TreeFamiTF105081

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1PEX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR
60 70 80 90 100
PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS
110 120 130 140 150
ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP
160 170 180 190 200
VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD
210 220 230 240 250
GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN KPTVYGVSPN
260 270 280 290 300
YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE
310 320 330 340 350
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN
360 370 380 390 400
RQEVNAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD
410 420 430 440 450
FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE
460 470 480 490 500
IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS
510 520 530 540 550
DRPSFAEIHQ AFETMFQESS ISDEVEKELG KKGVRGVAST LLQAPELPTK
560 570 580 590 600
TRTSRRAAEH KDPTDVPETP HTKGPGETDP LDHEPPVSPL LPRKERGPQD
610 620 630 640 650
SSLNEDERLL PKDKKTNLFS ALIKKKKKTA PTPPKRSSSF REMDGQPERK
660 670 680 690 700
AAVEEEGRET SNGVPALTTL DAAEPAKSPK PSSGAGVPNG AFRESGGPGF
710 720 730 740 750
RSPHLWKKSS TLTSSRLTAN EEESGGSSSK RFLRSCSASC VPHGAKDTEW
760 770 780 790 800
RSVTLPRDLQ STGRQFDSST FGGHKSEKPA LPRKRASENR SDQVTRGTVT
810 820 830 840 850
PPPRLVKKTE DAADEVFRDM GESSPGSSPP SLTPKLLRKQ VSGAPSSSLP
860 870 880 890 900
HKDEAGKSSA LGTPTTAELG TPASRGGPGM SGGASKAPAE EPRARRHKPS
910 920 930 940 950
SESPGRDKGK LSKLKPVPPP PLPASIGKAG KPSQSLSQEA AGEASTGGKA
960 970 980 990 1000
KAAAVVVDAV NSDTVKPGLL GEGVKKPVLP SMPKPQSSGK PAGTPASPAS
1010 1020 1030 1040 1050
APSTLSSASS ALAVDQPAST AFIPLISTRV SLRKTRQPPE RIASGTITKG
1060 1070 1080 1090 1100
VVLDGTEALC LAISKNSEQM ASHSAVLEAG KNLYTFCVSY VDSIQQMRNK
1110 1120 1130 1140 1150
FAFREAINKL ENNLRELQIC PATAGSGPAA TQDFSKLLSS VKEISDIVQR
Length:1,150
Mass (Da):125,079
Last modified:October 31, 2012 - v2
Checksum:i85B0AAC1EEAEA7CC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1PEX7F1PEX7_CANLF
Tyrosine-protein kinase
ABL1
1,131Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006835 Genomic DNA No translation available.
RefSeqiXP_548413.3, XM_548413.5

Genome annotation databases

EnsembliENSCAFT00000031723; ENSCAFP00000029535; ENSCAFG00000019938
GeneIDi491292

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006835 Genomic DNA No translation available.
RefSeqiXP_548413.3, XM_548413.5

3D structure databases

ProteinModelPortaliF1PEX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029535

Proteomic databases

PaxDbiF1PEX6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000031723; ENSCAFP00000029535; ENSCAFG00000019938
GeneIDi491292

Organism-specific databases

CTDi25
VGNCiVGNC:54912 ABL1

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119011
InParanoidiF1PEX6
OMAiGAFRESG
OrthoDBiEOG091G0D46
TreeFamiTF105081

Enzyme and pathway databases

ReactomeiR-CFA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-CFA-375170 CDO in myogenesis
R-CFA-428890 Role of ABL in ROBO-SLIT signaling
R-CFA-5663213 RHO GTPases Activate WASPs and WAVEs
R-CFA-5685938 HDR through Single Strand Annealing (SSA)
R-CFA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CFA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Gene expression databases

BgeeiENSCAFG00000019938 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1PEX6_CANLF
AccessioniPrimary (citable) accession number: F1PEX6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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