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Entry version 54 (02 Jun 2021)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Folliculin interacting protein 2

Gene

FNIP2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-9639288, Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Folliculin interacting protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNIP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:40936, FNIP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, LysosomeARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1PDY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000008700, Expressed in testis and 54 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000012778

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 1134UDENN FNIP1/2-typeInterPro annotationAdd BLAST1098

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 112DisorderedSequence analysisAdd BLAST20
Regioni601 – 733DisorderedSequence analysisAdd BLAST133
Regioni912 – 933DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 108Polar residuesSequence analysisAdd BLAST16
Compositional biasi707 – 733Basic and acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNIP family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3693, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003447_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1PDY0

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFQEPAL

TreeFam database of animal gene trees

More...
TreeFami
TF324090

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037545, DENN_FNIP1/2
IPR028086, FNIP_C_dom
IPR026156, FNIP_fam
IPR028085, FNIP_mid_dom
IPR028084, FNIP_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14638, FNIP_C, 1 hit
PF14637, FNIP_M, 1 hit
PF14636, FNIP_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02073, FOLLICULNIP1

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51836, DENN_FNIP12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F1PDY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLCRLFFGQ RNYTLDGRNN RRRSQMSTWC SWSCSEFDLN EIRLIVYQDC
60 70 80 90 100
ERRGRQVLFD SKAVHKIEEV ATQKTEDVPI KLSAKCCQGS GGGSSVSSHS
110 120 130 140 150
SSGGSLQHAK EQLPKYQYTR PASDVNMLGE MMFGSVAMSY KGSTLKIHYI
160 170 180 190 200
RSPPQLMISK VFSARMGSFC GSTNNLQDSF EYIHQDPNLG KLNTNQNNLG
210 220 230 240 250
PCRTGSNLGL LQACSSKLLQ GVAEGGPLRL TRSASFFAAH STPVDMPSRG
260 270 280 290 300
QNEDRDSGIA RSASLSSLLI TPFPSPSSST SSSSSYQRRW LRSQTTSLEN
310 320 330 340 350
GIIPRRSTDE TFSLAEETCS SNPAIVRRKK IAISIIFSLC EKEDAQRNFQ
360 370 380 390 400
DFFFSHFPLF ESHMNRLKSA IEKAMISCRK IAESSLRVQF YVSRLMEALG
410 420 430 440 450
EFRGTIWNLY SVPRIAEPVW LTMMSSTLEK TQLCQRFLKE FTLLIEQINK
460 470 480 490 500
NQFFAALLTA VLTYHLAWVP TVMPVDHPPI KAFSEKRTSQ SVNTLAKTHP
510 520 530 540 550
YNPLWAQLGD LYGAIGSPVR LTRTVVVGKQ KDLVQRILYV LTYFLRCSEL
560 570 580 590 600
QENQLTWNGS HGEGDQVLNG SNITTALERG EVEESEYVVV TVRSEPALLP
610 620 630 640 650
PILPPTMAEG RSPRPEGLSV SPEGTDIRDL CTKPDKEGNT RPEQSSQACS
660 670 680 690 700
MEFQEPALDS SWKPQGTFCG EEESERGAPQ DGSSRFSSCE GLGAGGKLSQ
710 720 730 740 750
QAVSEELKGE MPKKLTDRSA AWPCPDRHPW EKPPLEKVTF QIGSSVSPES
760 770 780 790 800
DFESRTQKME KRLTACRQYP ELACHPLAKS GMAADMPQDQ QLSRCFFTPG
810 820 830 840 850
FQKNGHCPQS QSYERDEGEF ERDFAEDRGI KTKVVAAATG QPDQSADSLA
860 870 880 890 900
PNGSAAGTGA RMLEKTRHLY LKDAEGPLMP PVPSRCAQQD SGFSGTADVP
910 920 930 940 950
CGDADRKANF RMEGDIPRNE SSDSALGDSD EEACASASLN LEHSNDPTEG
960 970 980 990 1000
SLEVELPLPR SQSISNPNVR NFGRSLLAGY CPTYMPDLVL HGTSSDEKLK
1010 1020 1030 1040 1050
QCLVADLVHT VHHPVLDEPI AEAVCIIADT DKWSVQVATS QRKVTDSMKL
1060 1070 1080 1090 1100
GQDVLVSSQV SSLLHSILQL YKLHLPADFC IMHLEDRLQE MYLKSKMLSE
1110 1120 1130 1140
YLRGHTRVHV KELGVVLGIE SNDLPLLTAI ASTHSPYVAQ ILL
Length:1,143
Mass (Da):126,599
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AD2E89A7FC519BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F4DF76A0A5F4DF76_CANLF
Folliculin interacting protein 2
FNIP2
1,172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4BTE3A0A5F4BTE3_CANLF
Folliculin interacting protein 2
FNIP2
1,148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4CCK6A0A5F4CCK6_CANLF
Folliculin interacting protein 2
FNIP2
1,128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4D7K0A0A5F4D7K0_CANLF
Folliculin interacting protein 2
FNIP2
1,075Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03010086 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000013815; ENSCAFP00000012778; ENSCAFG00000008700

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03010086 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000012778

Proteomic databases

PaxDbiF1PDY0

Genome annotation databases

EnsembliENSCAFT00000013815; ENSCAFP00000012778; ENSCAFG00000008700

Organism-specific databases

VGNCiVGNC:40936, FNIP2

Phylogenomic databases

eggNOGiKOG3693, Eukaryota
GeneTreeiENSGT00390000009391
HOGENOMiCLU_003447_0_0_1
InParanoidiF1PDY0
OMAiGFQEPAL
TreeFamiTF324090

Enzyme and pathway databases

ReactomeiR-CFA-9639288, Amino acids regulate mTORC1

Gene expression databases

BgeeiENSCAFG00000008700, Expressed in testis and 54 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR037545, DENN_FNIP1/2
IPR028086, FNIP_C_dom
IPR026156, FNIP_fam
IPR028085, FNIP_mid_dom
IPR028084, FNIP_N_dom
PfamiView protein in Pfam
PF14638, FNIP_C, 1 hit
PF14637, FNIP_M, 1 hit
PF14636, FNIP_N, 1 hit
PRINTSiPR02073, FOLLICULNIP1
PROSITEiView protein in PROSITE
PS51836, DENN_FNIP12, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PDY0_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PDY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 54 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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