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Entry version 46 (05 Dec 2018)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Collagen type XXIV alpha 1 chain

Gene

COL24A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-8874081 MET activates PTK2 signaling
R-CFA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XXIV alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL24A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:39469 COL24A1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500326748538 – 1326Sequence analysisAdd BLAST1289

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000020270 Expressed in 1 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1PBX4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 228LAM_G_DOMAINInterPro annotationAdd BLAST188

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162448

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1PBX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLGAHRTRR GKVSHTAQTK LLLHFIVLCV AGGVVHAQEQ GIDILHQLGL
60 70 80 90 100
GGKDVRHSSS VTAVPSSSTS LPQGVHLTEL GVILTNDAYI ESPLMKILPF
110 120 130 140 150
NLEQPFTILI GLQSHRVNNA FLFSIRNKNR LQLGVQLLPK KLVVYLGGKQ
160 170 180 190 200
SVFFNYSVHN ERWHSFAITI RNQVVSMFVE CGKKSFSRET LSEVQTFDSN
210 220 230 240 250
SVFTLGSMNN NSVHFEGILC QLDIIPSAEV SADYCRYMKQ RCRPEISLLH
260 270 280 290 300
TTIKPAEILE NSPLPKKFGE KVLSEDTFTK GKSIPNMINN DSATVRKQQG
310 320 330 340 350
LQMSKSQSMS LHSSNVSAVD LVNHGIQAKE MITEEHTQTN LSLSVTHHLL
360 370 380 390 400
NKARTKSKEK FSSLPNVSDN VTQHNDRVTG LLPFKKISSV LPHIKQETMI
410 420 430 440 450
NLKKAIAANL HTNELMELQQ ILNTTLYRVT DEPSVDNHLD LRKEGEFDPD
460 470 480 490 500
ATYPIENSYE TDLYDYYYYY EDLNTMLEME TLRGPKGDPG PPGPPGPAGI
510 520 530 540 550
PGPSGKRGPR GIPGPHGNPG LPGLPGPKGP KGDPGFSPGQ AVPGEKGNQG
560 570 580 590 600
LSGLMGPPGM QGDKGLKGYP GLPGPRGEPG IPGFTGNIGS RGYPGRQGLA
610 620 630 640 650
GPEGNPGPKG VRGFIGSPGE VGQLGPEGER GVPGIRGKKG LKGRQGFPGD
660 670 680 690 700
IGIPGQNGPE GLKGLLGNRG PPGPPGLKGL QGEEGPIGPF GELGPRGKPG
710 720 730 740 750
QKGYAGEPGP EGLKGEVGDQ GNIGKIGETG PIGLPGEVGI TGSIGEKGER
760 770 780 790 800
GSPGPLGPQG EKGVMGYPGP PGDPGPIGPL GLPGHVGARG PPGSQGPKGQ
810 820 830 840 850
RGPRGPDGLL GEQGIQGAKG EKGDQGKRGP YGLIGKTGNP GERGVQGKPG
860 870 880 890 900
LQGPPGSTGE RGLEGEPGPR GLQGDAGPPG EMGAEGPSGI EGESGLPGEP
910 920 930 940 950
GAKGNVGPAG NVGVAGEPGL RGEPGAPGEE GLQGKDGLKG NPGGRGLSGE
960 970 980 990 1000
DGEKGETGLP GATGPLGRPG LMGPPGPEGI VGSPGQRGRP GKKGDKGQIG
1010 1020 1030 1040 1050
PTGEIGNRGA PGQIGESGPK GARGTRGAVG HLGLIGPDGE PGIPGYRGHQ
1060 1070 1080 1090 1100
GQPGLPGLPG PKGEKGYPGE DSTVLGPPGP RGEPGIIGEQ GERGEPGEEG
1110 1120 1130 1140 1150
YKGHVGLPGP RGATGQQGPP GEPGDQGEQG LKGERGSEGP KGKKGAPGPS
1160 1170 1180 1190 1200
GKPGIPGLPG LPGPKGIQGY HGADGLSGNS GKAGLPGNQG VPGTRGSPGR
1210 1220 1230 1240 1250
TGLTGSPGPR GAKGSSGLPG SPGVPGPKGE QGLPGEPGIQ GKRGHRGAQG
1260 1270 1280 1290 1300
DQGPCGEPGL KGQPGEHGVQ GLTGFQGFPG PRGPEGDAGI VGISGPKGPI
1310 1320
GQRGNTGPFG KEGIIGPTGR TGPRGE
Length:1,326
Mass (Da):134,879
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A2DBE48297AB559
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2R8U5E2R8U5_CANLF
Collagen type XXIV alpha 1 chain
COL24A1
1,710Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03004847 Genomic DNA No translation available.
AAEX03004848 Genomic DNA No translation available.
AAEX03004849 Genomic DNA No translation available.
AAEX03004850 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000032286; ENSCAFP00000030066; ENSCAFG00000020270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03004847 Genomic DNA No translation available.
AAEX03004848 Genomic DNA No translation available.
AAEX03004849 Genomic DNA No translation available.
AAEX03004850 Genomic DNA No translation available.

3D structure databases

SMRiF1PBX4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000032286; ENSCAFP00000030066; ENSCAFG00000020270

Organism-specific databases

VGNCiVGNC:39469 COL24A1

Phylogenomic databases

GeneTreeiENSGT00940000162448

Enzyme and pathway databases

ReactomeiR-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-8874081 MET activates PTK2 signaling
R-CFA-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSCAFG00000020270 Expressed in 1 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01391 Collagen, 9 hits
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PBX4_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PBX4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: December 5, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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