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Protein
Submitted name:

Myeloid differentiation primary response 88

Gene

MYD88

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-1257604 PIP3 activates AKT signaling
R-CFA-1810476 RIP-mediated NFkB activation via ZBP1
R-CFA-209543 p75NTR recruits signalling complexes
R-CFA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-CFA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-CFA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CFA-9020702 Interleukin-1 signaling
R-CFA-933541 TRAF6 mediated IRF7 activation
R-CFA-933542 TRAF6 mediated NF-kB activation
R-CFA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-CFA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-CFA-975155 MyD88 dependent cascade initiated on endosome

Names & Taxonomyi

Protein namesi
Submitted name:
Myeloid differentiation primary response 88Imported
Gene namesi
Name:MYD88Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:43531 MYD88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1P7V2

Expressioni

Gene expression databases

BgeeiENSCAFG00000004966 Expressed in 3 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007386

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 211DeathInterPro annotationAdd BLAST78
Domaini261 – 398TIRInterPro annotationAdd BLAST138

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
GeneTreeiENSGT00510000048324
InParanoidiF1P7V2
OMAiRCKRMVV
OrthoDBiEOG091G0NDI
TreeFamiTF326264

Family and domain databases

CDDicd08312 Death_MyD88, 1 hit
Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

F1P7V2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPPPPGPPA PATALAPGGQ ELRCRCRVPV SLQPGPEGRG GHGPRPSHSC
60 70 80 90 100
GGGAGRGGAG RGFSETETGG AGRGRGRGCG GGGRRKRGPG TRRRRCGPRR
110 120 130 140 150
PAMAAEGSRA GSASPVCPKA SLPLAALNVR VRRRLSLFLN VRTQVAADWT
160 170 180 190 200
ALAEEMGFEY LEIRHLEMHA DPTGKLLDDW QGRPGASVGR LLELLTKLGR
210 220 230 240 250
DDVLVELGPS IEEDCQKYIL KQQQEESEKP LQVPAVDSSD PRTPERGGIT
260 270 280 290 300
MLDDPSGQMP ERFDAFICYC PSDIQFVQEM IRQLEQTNYR LKLCVSDRDV
310 320 330 340 350
LPGTCVWSIA SELIEKRCRR MVVVVSDDYL QSRECDFQTK FALSLSPGAH
360 370 380 390
QKRLIPIKYK AMKKEFPSIL RFITVCDYTN PCTKSWFWTR LAKALSLP
Length:398
Mass (Da):43,649
Last modified:October 31, 2012 - v2
Checksum:i6BC018465510ADF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013489 Genomic DNA No translation available.
RefSeqiXP_534223.3, XM_534223.5

Genome annotation databases

EnsembliENSCAFT00000007977; ENSCAFP00000007386; ENSCAFG00000004966
GeneIDi477024

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013489 Genomic DNA No translation available.
RefSeqiXP_534223.3, XM_534223.5

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007386

Proteomic databases

PaxDbiF1P7V2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000007977; ENSCAFP00000007386; ENSCAFG00000004966
GeneIDi477024

Organism-specific databases

CTDi4615
VGNCiVGNC:43531 MYD88

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
GeneTreeiENSGT00510000048324
InParanoidiF1P7V2
OMAiRCKRMVV
OrthoDBiEOG091G0NDI
TreeFamiTF326264

Enzyme and pathway databases

ReactomeiR-CFA-1257604 PIP3 activates AKT signaling
R-CFA-1810476 RIP-mediated NFkB activation via ZBP1
R-CFA-209543 p75NTR recruits signalling complexes
R-CFA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-CFA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-CFA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CFA-9020702 Interleukin-1 signaling
R-CFA-933541 TRAF6 mediated IRF7 activation
R-CFA-933542 TRAF6 mediated NF-kB activation
R-CFA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-CFA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-CFA-975155 MyD88 dependent cascade initiated on endosome

Gene expression databases

BgeeiENSCAFG00000004966 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd08312 Death_MyD88, 1 hit
Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1P7V2_CANLF
AccessioniPrimary (citable) accession number: F1P7V2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: October 10, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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