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Protein

Phosphodiesterase

Gene

PDE8B

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-GGA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:PDE8BImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Expressioni

Gene expression databases

BgeeiENSGALG00000004339 Expressed in 4 organ(s), highest expression level in kidney

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 319PASInterPro annotationAdd BLAST65
Domaini523 – 864PDEaseInterPro annotationAdd BLAST342

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118889
KOiK18437
OrthoDBiEOG091G0337

Family and domain databases

CDDicd00077 HDc, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013938 PDEase_PDE8
PfamiView protein in Pfam
PF13426 PAS_9, 1 hit
PF08629 PDE8, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1P2B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCAPSIHVS QSGVIYCRDS DESNSPHQTT TISQGASTLH GLFVKSDAAD
60 70 80 90 100
SIPAVLAYQS RQQPPCSGPR RRESRAPRCC GIEAETQTSS SSLKQASATE
110 120 130 140 150
VQIGPMRLTQ DPVQVLLIFA KEDNQSDGFW WACDRAGYRC NIARTPESAL
160 170 180 190 200
ECFLDKHQEI IVIDHRNSRY FDAEDICRSI RATKPSEHTV ILAVVPRTSA
210 220 230 240 250
DQEETSVLPL LNAGFDRQFM ENSSITACYN ELIQIEHGEV RSQFKLRACN
260 270 280 290 300
AVFTALEHCQ EAIEITSEDH IIQYVNPAFE QMMGYHKGEL IGKELTELPK
310 320 330 340 350
SDKNRADLSD SINACIKKGK EWQGVYYARR KSGDSIQQHV KITPVIGQGG
360 370 380 390 400
KIRHFVSLKR LRCTNENNKQ LCKSHRDENY SGDNSQSESH SFKCKNRRKD
410 420 430 440 450
SIDVKSTTSQ SSDAPSVQTR RYSSMARIHS MTIEAPITKV INIINAAQEN
460 470 480 490 500
SPITVAEALD RVLEILRTTE LYSPQLGTKD EDPHTSDLVG GLMTDGLRRL
510 520 530 540 550
SGNEYVCSKN LNLSHSHLSV PNTINDVPPC IAQLLDNEES WDFNIFELEA
560 570 580 590 600
VTNKRPLVYL GLKVFGRFGV PEFLNCSEAT LRAWLQVIEA NYHSSNAYHN
610 620 630 640 650
STHAADVLHA TAFFLGKERV KGSLDHLDEV AALIAATIHD VDHPGRTNSF
660 670 680 690 700
LCNAGSELAV LYNDTAVLES HHTALAFQLT AKDSKCNIFK NIDRNRYRTL
710 720 730 740 750
RQAIIDMVLA TEMTKHFEHV NKFVNSINKP MASEETGSHN EGSDCECTAN
760 770 780 790 800
LKNFPDNQTL IKRMMIKCAD VANPCRPLEL CIEWAGRISE EYFAQTDEEK
810 820 830 840 850
RQGLPVVMPV FDRNTCSIPK SQISFIDYFI TDMFDAWDAF AHLPVLMQHL
860 870
ANNYKHWKML DELKCKSLRL PSENNN
Length:876
Mass (Da):98,385
Last modified:November 30, 2016 - v3
Checksum:iD26CE0A24C4EBCF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC202792 Genomic DNA No translation available.
RefSeqiXP_004937385.1, XM_004937328.2

Genome annotation databases

EnsembliENSGALT00000038586; ENSGALP00000037794; ENSGALG00000004339
GeneIDi427645
KEGGigga:427645

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC202792 Genomic DNA No translation available.
RefSeqiXP_004937385.1, XM_004937328.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000038586; ENSGALP00000037794; ENSGALG00000004339
GeneIDi427645
KEGGigga:427645

Organism-specific databases

CTDi8622

Phylogenomic databases

GeneTreeiENSGT00760000118889
KOiK18437
OrthoDBiEOG091G0337

Enzyme and pathway databases

ReactomeiR-GGA-418555 G alpha (s) signalling events

Gene expression databases

BgeeiENSGALG00000004339 Expressed in 4 organ(s), highest expression level in kidney

Family and domain databases

CDDicd00077 HDc, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013938 PDEase_PDE8
PfamiView protein in Pfam
PF13426 PAS_9, 1 hit
PF08629 PDE8, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1P2B9_CHICK
AccessioniPrimary (citable) accession number: F1P2B9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: September 12, 2018
This is version 55 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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