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Protein

ATP-citrate synthase

Gene

ACLY

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.UniRule annotation

Catalytic activityi

ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei750Tele-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processLipid biosynthesisUniRule annotation, Lipid metabolism
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-163765 ChREBP activates metabolic gene expression
R-GGA-6798695 Neutrophil degranulation
R-GGA-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-citrate synthaseUniRule annotation (EC:2.3.3.8UniRule annotation)
Alternative name(s):
ATP-citrate (pro-S-)-lyaseUniRule annotation
Citrate cleavage enzymeUniRule annotation
Gene namesi
Name:ACLYImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF1P269

Expressioni

Gene expression databases

BgeeiENSGALG00000003475 Expressed in 11 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005492

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini482 – 591CoA_bindingInterPro annotationAdd BLAST110

Sequence similaritiesi

In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1254 Eukaryota
COG0045 LUCA
COG0074 LUCA
COG0372 LUCA
GeneTreeiENSGT00530000063275
OMAiTCRFATV
OrthoDBiEOG091G0OYH

Family and domain databases

Gene3Di1.10.230.10, 1 hit
3.30.1490.20, 1 hit
3.40.50.261, 2 hits
InterProiView protein in InterPro
IPR014608 ATP-citrate_synthase
IPR013815 ATP_grasp_subdomain_1
IPR017440 Cit_synth/succinyl-CoA_lig_AS
IPR032263 Citrate-bd
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR036969 Citrate_synthase_sf
IPR033847 Citrt_syn/SCS-alpha_CS
IPR003781 CoA-bd
IPR005811 CoA_ligase
IPR036291 NAD(P)-bd_dom_sf
IPR017866 Succ-CoA_synthase_bsu_CS
IPR016102 Succinyl-CoA_synth-like
PfamiView protein in Pfam
PF16114 Citrate_bind, 1 hit
PF00285 Citrate_synt, 1 hit
PF02629 CoA_binding, 1 hit
PF00549 Ligase_CoA, 1 hit
PIRSFiPIRSF036511 ATP_citrt_syn, 1 hit
SMARTiView protein in SMART
SM00881 CoA_binding, 1 hit
SUPFAMiSSF48256 SSF48256, 1 hit
SSF51735 SSF51735, 1 hit
SSF52210 SSF52210, 1 hit
PROSITEiView protein in PROSITE
PS01216 SUCCINYL_COA_LIG_1, 1 hit
PS00399 SUCCINYL_COA_LIG_2, 1 hit
PS01217 SUCCINYL_COA_LIG_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F1P269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKAISEQT GKEFLYKYIC TSSAIQNRFK YARVTPDTDW ARLTQDHPWL
60 70 80 90 100
LSERLVVKPD QLIKRRGKLG LVGINLTLDQ VKVWLKQRLG QETTIANAKG
110 120 130 140 150
ILKNFLIEPF VPHKQEEEFY VCIYAAREGD YVLFYHEGGV DVGDVDAKAQ
160 170 180 190 200
KLLVAVDEKL NESDVKKHLL QHAPADKKDI LASFICGLFN LYEDLYFTYL
210 220 230 240 250
EINPLVVTKD GVYILDLAAK IDATADYICK VKWGDVEFPP PFGREAYPEE
260 270 280 290 300
AYIADLDAKS GASLKLTILN PKGRIWTMVA GGGASVVYSD TICDLGGVNE
310 320 330 340 350
LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPEGKILII GGSIANFTNV
360 370 380 390 400
AATFKGIVRA IKDYQGPLKE HEVRIFVRRG GPNYQEGLRV MGEVGKTTGI
410 420 430 440 450
PIHVFGTETH MTAIVGMALG HRPIPNQPPT AAHTANFLLN ASGSPSTPAP
460 470 480 490 500
SRTASFSESK PDDIAPAKKA KPTAPLGKAT TLFSRHTKAI IWGMQTRAVQ
510 520 530 540 550
GMLDFDYICS RDEPSVAAMV YPFTGDHRQK FYWGHKEILI PVYKNMSDAM
560 570 580 590 600
RKHPEVDVLI NFASLRSAYD STVETMNYPQ IRTIAIIAEG IPEALTRKLI
610 620 630 640 650
KAADKKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV
660 670 680 690 700
SRSGGMSNEL NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV
710 720 730 740 750
KMIVVLGEIG GTEEYKICRG IKEGRITKPV VCWCIGTCAT MFSSEVQFGH
760 770 780 790 800
AGACANQASE TAVAKNQALK EAGVFVPRSF DELGEVIQSV YQDLVAKRVI
810 820 830 840 850
EPAEEVPPPT VPMDYSWARE LGLIRKPASF MTSICDERGQ ELIYAGMPIT
860 870 880 890 900
EVFKEEMGIG GVLGLLWFQR RLPKYACQFI EMCLMVTADH GPAVSGAHNT
910 920 930 940 950
IVCARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV
960 970 980 990 1000
NKMKKEGKLI MGIGHRVKSI NNPDMRVQIL KDYVKQHFPA TPLLDYALEV
1010 1020 1030 1040 1050
EKITTSKKPN LILNVDGFIG VAFVDVLRNC GSFTREEADE YIDIGALNGI
1060 1070 1080 1090
FVLGRSMGFI GHYLDQKRLK QGLYRHPWDD ISYVLPEHMT M
Length:1,091
Mass (Da):120,143
Last modified:June 26, 2013 - v2
Checksum:i133FB048AF49147F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PSE5A0A1D5PSE5_CHICK
ATP-citrate synthase
ACLY
1,101Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000464 Genomic DNA No translation available.
RefSeqiXP_015155067.1, XM_015299581.1
UniGeneiGga.2159

Genome annotation databases

EnsembliENSGALT00000039950; ENSGALP00000039157; ENSGALG00000003475

Similar proteinsi

Entry informationi

Entry nameiF1P269_CHICK
AccessioniPrimary (citable) accession number: F1P269
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: September 12, 2018
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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